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Sodium channel, nonvoltage-gated 1, delta
Symbols SCNN1D; ENaCd; ENaCdelta; MGC149710; MGC149711; SCNED; dNaCh
External IDs OMIM601328 HomoloGene48152 GeneCards: SCNN1D Gene
RNA expression pattern
PBB GE SCNN1D 208458 at tn.png
More reference expression data
Species Human Mouse
Entrez 6339 n/a
Ensembl ENSG00000162572 n/a
UniProt P51172 n/a
RefSeq (mRNA) NM_002978 n/a
RefSeq (protein) NP_002969 n/a
Location (UCSC) Chr 1:
1.21 - 1.22 Mb
PubMed search [1] n/a

Amiloride-sensitive sodium channel subunit delta is a protein that in humans is encoded by the SCNN1D gene.[1][2]


See also


  1. ^ Waldmann R, Bassilana F, Voilley N, Lazdunski M, Mattei M (Feb 1997). "Assignment of the human amiloride-sensitive Na+ channel delta isoform to chromosome 1p36.3-p36.2". Genomics 34 (2): 262-3. PMID 8661065.  
  2. ^ "Entrez Gene: SCNN1D sodium channel, nonvoltage-gated 1, delta".  

Further reading

  • Waldmann R, Champigny G, Bassilana F, et al. (1996). "Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel.". J. Biol. Chem. 270 (46): 27411–4. doi:10.1074/jbc.270.46.27411. PMID 7499195.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Biasio W, Chang T, McIntosh CJ, McDonald FJ (2004). "Identification of Murr1 as a regulator of the human delta epithelial sodium channel.". J. Biol. Chem. 279 (7): 5429–34. doi:10.1074/jbc.M311155200. PMID 14645214.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Yamamura H, Ugawa S, Ueda T, et al. (2004). "Protons activate the delta-subunit of the epithelial Na+ channel in humans.". J. Biol. Chem. 279 (13): 12529–34. doi:10.1074/jbc.M400274200. PMID 14726523.  
  • Ji HL, Benos DJ (2004). "Degenerin sites mediate proton activation of deltabetagamma-epithelial sodium channel.". J. Biol. Chem. 279 (26): 26939–47. doi:10.1074/jbc.M401143200. PMID 15084585.  
  • Yamamura H, Ugawa S, Ueda T, et al. (2004). "Capsazepine is a novel activator of the delta subunit of the human epithelial Na+ channel.". J. Biol. Chem. 279 (43): 44483–9. doi:10.1074/jbc.M408929200. PMID 15308635.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Ji HL, Su XF, Kedar S, et al. (2006). "Delta-subunit confers novel biophysical features to alpha beta gamma-human epithelial sodium channel (ENaC) via a physical interaction.". J. Biol. Chem. 281 (12): 8233–41. doi:10.1074/jbc.M512293200. PMID 16423824.  
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.  
  • Yamamura H, Ugawa S, Ueda T, et al. (2006). "A novel spliced variant of the epithelial Na+ channel delta-subunit in the human brain.". Biochem. Biophys. Res. Commun. 349 (1): 317–21. doi:10.1016/j.bbrc.2006.08.043. PMID 16930535.  
  • Giraldez T, Afonso-Oramas D, Cruz-Muros I, et al. (2007). "Cloning and functional expression of a new epithelial sodium channel delta subunit isoform differentially expressed in neurons of the human and monkey telencephalon.". J. Neurochem. 102 (4): 1304–15. doi:10.1111/j.1471-4159.2007.04622.x. PMID 17472699.  

External links



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