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Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D

PDB rendering based on 1olz.
Available structures
Symbols SEMA4D; CD100; M-sema G; M-sema-G; SEMAJ; coll-4
External IDs OMIM601866 MGI109244 HomoloGene21282 GeneCards: SEMA4D Gene
RNA expression pattern
PBB GE SEMA4D 203528 at tn.png
More reference expression data
Species Human Mouse
Entrez 10507 20354
Ensembl ENSG00000187764 ENSMUSG00000021451
UniProt Q92854 Q6GTM9
RefSeq (mRNA) NM_006378 NM_013660
RefSeq (protein) NP_006369 NP_038688
Location (UCSC) Chr 9:
91.18 - 91.3 Mb
Chr 13:
51.71 - 51.81 Mb
PubMed search [1] [2]

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D (SEMA4D) also known as CD100 (Cluster of Differentiation 100), is a protein which in humans is encoded by the SEMA4D gene.[1]



Semaphorin 4D (Sema 4D) is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system.[2]

See also


Further reading

  • Bougeret C, Mansur IG, Dastot H, et al. (1992). "Increased surface expression of a newly identified 150-kDa dimer early after human T lymphocyte activation.". J. Immunol. 148 (2): 318–23. PMID 1530858.  
  • Hall KT, Boumsell L, Schultze JL, et al. (1996). "Human CD100, a novel leukocyte semaphorin that promotes B-cell aggregation and differentiation.". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11780–5. doi:10.1073/pnas.93.21.11780. PMID 8876214.  
  • Herold C, Elhabazi A, Bismuth G, et al. (1997). "CD100 is associated with CD45 at the surface of human T lymphocytes. Role in T cell homotypic adhesion.". J. Immunol. 157 (12): 5262–8. PMID 8955171.  
  • Furuyama T, Inagaki S, Kosugi A, et al. (1997). "Identification of a novel transmembrane semaphorin expressed on lymphocytes.". J. Biol. Chem. 271 (52): 33376–81. doi:10.1074/jbc.271.52.33376. PMID 8969198.  
  • Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.". Cell 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.  
  • Kumanogoh A, Watanabe C, Lee I, et al. (2001). "Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling.". Immunity 13 (5): 621–31. doi:10.1016/S1074-7613(00)00062-5. PMID 11114375.  
  • Elhabazi A, Delaire S, Bensussan A, et al. (2001). "Biological activity of soluble CD100. I. The extracellular region of CD100 is released from the surface of T lymphocytes by regulated proteolysis.". J. Immunol. 166 (7): 4341–7. PMID 11254687.  
  • Delaire S, Billard C, Tordjman R, et al. (2001). "Biological activity of soluble CD100. II. Soluble CD100, similarly to H-SemaIII, inhibits immune cell migration.". J. Immunol. 166 (7): 4348–54. PMID 11254688.  
  • Vikis HG, Li W, Guan KL (2002). "The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding.". Genes Dev. 16 (7): 836–45. doi:10.1101/gad.966402. PMID 11937491.  
  • Granziero L, Circosta P, Scielzo C, et al. (2003). "CD100/Plexin-B1 interactions sustain proliferation and survival of normal and leukemic CD5+ B lymphocytes.". Blood 101 (5): 1962–9. doi:10.1182/blood-2002-05-1339. PMID 12406905.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.  
  • Ishida I, Kumanogoh A, Suzuki K, et al. (2004). "Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses.". Int. Immunol. 15 (8): 1027–34. doi:10.1093/intimm/dxg098. PMID 12882840.  
  • Love CA, Harlos K, Mavaddat N, et al. (2003). "The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D.". Nat. Struct. Biol. 10 (10): 843–8. doi:10.1038/nsb977. PMID 12958590.  
  • Giraudon P, Vincent P, Vuaillat C, et al. (2004). "Semaphorin CD100 from activated T lymphocytes induces process extension collapse in oligodendrocytes and death of immature neural cells.". J. Immunol. 172 (2): 1246–55. PMID 14707103.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Deaglio S, Vaisitti T, Bergui L, et al. (2005). "CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival.". Blood 105 (8): 3042–50. doi:10.1182/blood-2004-10-3873. PMID 15613544.  
  • Conrotto P, Valdembri D, Corso S, et al. (2005). "Sema4D induces angiogenesis through Met recruitment by Plexin B1.". Blood 105 (11): 4321–9. doi:10.1182/blood-2004-07-2885. PMID 15632204.  
  • Basile JR, Afkhami T, Gutkind JS (2005). "Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Src, and the phosphatidylinositol 3-kinase-Akt pathway.". Mol. Cell. Biol. 25 (16): 6889–98. doi:10.1128/MCB.25.16.6889-6898.2005. PMID 16055703.  
  • Lewandrowski U, Moebius J, Walter U, Sickmann A (2006). "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.". Mol. Cell Proteomics 5 (2): 226–33. doi:10.1074/mcp.M500324-MCP200. PMID 16263699.  

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