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SEP-225,289: Wikis

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Systematic (IUPAC) name
CAS number  ?
ATC code  ?
PubChem 9900576
Chemical data
Formula C 15H22ClN 
Mol. mass 251.794 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

SEP-225,289 is an antidepressant drug derived from sibutramine, which is being developed by Sepracor and is currently in clinical trials. It is a so-called triple reuptake inhibitor (TRI)[1]



Details for the synthesis of agents of this type were recently discovered: U.S. Patent 7,129,378

1-(4-chlorophenyl)cyclobutanecarbonitrile is reacted with i-BuMX in the first step.

See attachment for the ensuing reactions, which lie outside the scope of wikipedia.

Relevant Patents


  1. ^ Chen, Z.; Skolnick, P. (2007). "Triple uptake inhibitors: therapeutic potential in depression and beyond". Expert opinion on investigational drugs 16 (9): 1365–1377. doi:10.1517/13543784.16.9.1365. PMID 17714023.   edit

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