The Full Wiki

More info on SEP-225,289

SEP-225,289: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

(Redirected to SEP-225289 article)

From Wikipedia, the free encyclopedia

SEP-225289
Systematic (IUPAC) name
(1R)-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutan-1-amine
Identifiers
CAS number  ?
ATC code  ?
PubChem 9900576
Chemical data
Formula C 15H22ClN 
Mol. mass 251.794 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.  ?
Legal status
Routes  ?

SEP-225,289 is an antidepressant drug derived from sibutramine, which is being developed by Sepracor and is currently in clinical trials. It is a so-called triple reuptake inhibitor (TRI)[1]

Contents

Chemistry

Details for the synthesis of agents of this type were recently discovered: U.S. Patent 7,129,378

1-(4-chlorophenyl)cyclobutanecarbonitrile is reacted with i-BuMX in the first step.

See attachment for the ensuing reactions, which lie outside the scope of wikipedia.

Relevant Patents

References

  1. ^ Chen, Z.; Skolnick, P. (2007). "Triple uptake inhibitors: therapeutic potential in depression and beyond". Expert opinion on investigational drugs 16 (9): 1365–1377. doi:10.1517/13543784.16.9.1365. PMID 17714023.   edit

External links








Got something to say? Make a comment.
Your name
Your email address
Message