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SIN3B: Wikis


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SIN3 homolog B, transcription regulator (yeast)

PDB rendering based on 1e91.
Available structures
1e91, 1pd7, 2cr7, 2czy, 2f05
Symbols SIN3B; KIAA0700
External IDs OMIM607777 MGI107158 HomoloGene81810 GeneCards: SIN3B Gene
RNA expression pattern
PBB GE SIN3B 209352 s at tn.png
PBB GE SIN3B 39705 at tn.png
More reference expression data
Species Human Mouse
Entrez 23309 20467
Ensembl ENSG00000127511 ENSMUSG00000031622
UniProt O75182 Q3TN09
RefSeq (mRNA) NM_015260 NM_009188
RefSeq (protein) NP_056075 NP_033214
Location (UCSC) Chr 19:
16.8 - 16.85 Mb
Chr 8:
75.62 - 75.65 Mb
PubMed search [1] [2]

Paired amphipathic helix protein Sin3b is a protein that in humans is encoded by the SIN3B gene.[1][2]



SIN3B has been shown to interact with HDAC1,[3][4] Zinc finger and BTB domain-containing protein 16,[5] SUDS3[6] and IKZF1.[4][7]

See also


  1. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169–76. PMID 9734811.  
  2. ^ "Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast)".  
  3. ^ Zhang, Y; Ng H H, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (Aug. 1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes Dev. (UNITED STATES) 13 (15): 1924–35. ISSN 0890-9369. PMID 10444591.  
  4. ^ a b Koipally, J; Renold A, Kim J, Georgopoulos K (Jun. 1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". EMBO J. (ENGLAND) 18 (11): 3090–100. doi:10.1093/emboj/18.11.3090. ISSN 0261-4189. PMID 10357820.  
  5. ^ David, G; Alland L, Hong S H, Wong C W, DePinho R A, Dejean A (May. 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene (ENGLAND) 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. ISSN 0950-9232. PMID 9627120.  
  6. ^ Alland, Leila; David Gregory, Shen-Li Hong, Potes Jason, Muhle Rebecca, Lee Hye-Chun, Hou Harry, Chen Ken, DePinho Ronald A (Apr. 2002). "Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex". Mol. Cell. Biol. (United States) 22 (8): 2743–50. ISSN 0270-7306. PMID 11909966.  
  7. ^ Koipally, Joseph; Georgopoulos Katia (Aug. 2002). "A molecular dissection of the repression circuitry of Ikaros". J. Biol. Chem. (United States) 277 (31): 27697–705. doi:10.1074/jbc.M201694200. ISSN 0021-9258. PMID 12015313.  

Further reading

  • Ayer DE, Lawrence QA, Eisenman RN (1995). "Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3.". Cell 80 (5): 767–76. doi:10.1016/0092-8674(95)90355-0. PMID 7889570.  
  • David G, Alland L, Hong SH, et al. (1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein.". Oncogene 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. PMID 9627120.  
  • Koipally J, Renold A, Kim J, Georgopoulos K (1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes.". EMBO J. 18 (11): 3090–100. doi:10.1093/emboj/18.11.3090. PMID 10357820.  
  • Naruse Y, Aoki T, Kojima T, Mori N (2000). "Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes.". Proc. Natl. Acad. Sci. U.S.A. 96 (24): 13691–6. doi:10.1073/pnas.96.24.13691. PMID 10570134.  
  • Spronk CA, Tessari M, Kaan AM, et al. (2001). "The Mad1-Sin3B interaction involves a novel helical fold.". Nat. Struct. Biol. 7 (12): 1100–4. doi:10.1038/81944. PMID 11101889.  
  • Spronk CA, Jansen JF, Tessari M, et al. (2001). "Sequence-specific assignment of the PAH2 domain of Sin3B free and bound to Mad1.". J. Biomol. NMR 19 (4): 377–8. doi:10.1023/A:1011262214741. PMID 11370785.  
  • Alland L, David G, Shen-Li H, et al. (2002). "Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex.". Mol. Cell. Biol. 22 (8): 2743–50. doi:10.1128/MCB.22.8.2743-2750.2002. PMID 11909966.  
  • Rayman JB, Takahashi Y, Indjeian VB, et al. (2002). "E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex.". Genes Dev. 16 (8): 933–47. doi:10.1101/gad.969202. PMID 11959842.  
  • Koipally J, Georgopoulos K (2002). "A molecular dissection of the repression circuitry of Ikaros.". J. Biol. Chem. 277 (31): 27697–705. doi:10.1074/jbc.M201694200. PMID 12015313.  
  • Yang L, Mei Q, Zielinska-Kwiatkowska A, et al. (2003). "An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B.". Biochem. J. 369 (Pt 3): 651–7. doi:10.1042/BJ20020854. PMID 12398767.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Petrie K, Guidez F, Howell L, et al. (2003). "The histone deacetylase 9 gene encodes multiple protein isoforms.". J. Biol. Chem. 278 (18): 16059–72. doi:10.1074/jbc.M212935200. PMID 12590135.  
  • Wysocka J, Myers MP, Laherty CD, et al. (2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.". Genes Dev. 17 (7): 896–911. doi:10.1101/gad.252103. PMID 12670868.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Dugast-Darzacq C, Pirity M, Blanck JK, et al. (2004). "Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential.". Oncogene 23 (55): 8887–99. doi:10.1038/sj.onc.1208107. PMID 15467743.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Rampalli S, Pavithra L, Bhatt A, et al. (2005). "Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex.". Mol. Cell. Biol. 25 (19): 8415–29. doi:10.1128/MCB.25.19.8415-8429.2005. PMID 16166625.  
  • Xu Y, Sengupta PK, Seto E, Smith BD (2006). "Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression.". J. Biol. Chem. 281 (14): 9260–70. doi:10.1074/jbc.M511724200. PMID 16464847.  

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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