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From Wikipedia, the free encyclopedia

Signal-regulatory protein beta 1

PDB rendering based on 2d9c.
Available structures
Symbols SIRPB1; CD172b; DKFZp686A05192; SIRP-BETA-1
External IDs OMIM603889 HomoloGene88736 GeneCards: SIRPB1 Gene
RNA expression pattern
PBB GE SIRPB1 206934 at tn.png
PBB GE SIRPB1 217240 at tn.png
More reference expression data
Species Human Mouse
Entrez 10326 n/a
Ensembl ENSG00000101307 n/a
UniProt O00241 n/a
RefSeq (mRNA) NM_006065 n/a
RefSeq (protein) NP_006056 n/a
Location (UCSC) Chr 20:
1.49 - 1.55 Mb
PubMed search [1] n/a

Signal-regulatory protein beta-1 is a protein that in humans is encoded by the SIRPB1 gene.[1][2][3] SIRPB1 has also recently been designated CD172B (cluster of differentiation 172B).

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Alternatively spliced transcript variants have been found for this gene.[3]


SIRPB1 has been shown to interact with TYROBP.[4][5]


  1. ^ Kharitonenkov A, Chen Z, Sures I, Wang H, Schilling J, Ullrich A (Apr 1997). "A family of proteins that inhibit signalling through tyrosine kinase receptors". Nature 386 (6621): 181–6. doi:10.1038/386181a0. PMID 9062191.  
  2. ^ van den Berg TK, van Beek EM, Buhring HJ, Colonna M, Hamaguchi M, Howard CJ, Kasuga M, Liu Y, Matozaki T, Neel BG, Parkos CA, Sano S, Vignery A, Vivier E, Wright M, Zawatzky R, Barclay AN (Dec 2005). "A nomenclature for signal regulatory protein family members". J Immunol 175 (12): 7788–9. PMID 16339511.  
  3. ^ a b "Entrez Gene: SIRPB1 signal-regulatory protein beta 1".  
  4. ^ Dietrich, J; Cella M, Seiffert M, Bühring H J, Colonna M (Jan. 2000). "Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells". J. Immunol. (UNITED STATES) 164 (1): 9–12. ISSN 0022-1767. PMID 10604985.  
  5. ^ Tomasello, E; Cant C, Bühring H J, Vély F, André P, Seiffert M, Ullrich A, Vivier E (Aug. 2000). "Association of signal-regulatory proteins beta with KARAP/DAP-12". Eur. J. Immunol. (GERMANY) 30 (8): 2147–56. ISSN 0014-2980. PMID 10940905.  

Further reading

  • Dietrich J, Cella M, Seiffert M, et al. (2000). "Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells.". J. Immunol. 164 (1): 9–12. PMID 10604985.  
  • Tomasello E, Cant C, Bühring HJ, et al. (2000). "Association of signal-regulatory proteins beta with KARAP/DAP-12.". Eur. J. Immunol. 30 (8): 2147–56. doi:10.1002/1521-4141(2000)30:8<2147::AID-IMMU2147>3.0.CO;2-1. PMID 10940905.  
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.  
  • Cannon JP, Haire RN, Litman GW (2002). "Identification of diversified genes that contain immunoglobulin-like variable regions in a protochordate.". Nat. Immunol. 3 (12): 1200–7. doi:10.1038/ni849. PMID 12415263.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Liu Y, Soto I, Tong Q, et al. (2006). "SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration.". J. Biol. Chem. 280 (43): 36132–40. doi:10.1074/jbc.M506419200. PMID 16081415.  
  • Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMID 16335952.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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