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SKF 38393
IUPAC name
CAS number 67287-49-4
PubChem 1242
Molecular formula C16H17NO2
Molar mass 255.31168
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

SKF 38393 is a synthetic compound that acts as a selective D1 receptor agonist. The abbreviation SKF stands for Smith Kline and French, a pharmaceutical company which later became GlaxoSmithKline. SKF 38393 is used primarily as a research tool. It is commonly sold as the hydrochloride salt.


External links


Systematic (IUPAC) name
CAS number 67287-49-4
ATC code  ?
PubChem CID 1242
ChemSpider 1205
Chemical data
Formula C16H17NO2
Mol. mass 255.31 g/mol
SMILES eMolecules & PubChem
Therapeutic considerations
Pregnancy cat.  ?
Legal status

SKF-38,393 is a synthetic compound of the benzazepine chemical class which acts as a selective D1/D5 receptor partial agonist.[1] It has stimulant and anorectic effects.[2][3]


  1. ^ Dubois A, Savasta M, Curet O, Scatton B (September 1986). "Autoradiographic distribution of the D1 agonist [3HSKF 38393, in the rat brain and spinal cord. Comparison with the distribution of D2 dopamine receptors"]. Neuroscience 19 (1): 125–37. PMID 2946980. 
  2. ^ Trampus M, Ferri N, Adami M, Ongini E (April 1993). "The dopamine D1 receptor agonists, A68930 and SKF 38393, induce arousal and suppress REM sleep in the rat". European Journal of Pharmacology 235 (1): 83–7. PMID 8100197. 
  3. ^ Cooper SJ, Francis J, Rusk IN (1990). [Expression error: Unexpected < operator "The anorectic effect of SK&F 38393, a selective dopamine D1 receptor agonist: a microstructural analysis of feeding and related behaviour"]. Psychopharmacology 100 (2): 182–7. PMID 1968277. 


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