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SKF-83959 structure.png
IUPAC name
CAS number
PubChem 24278699
Molecular formula C18H20ClNO2
Molar mass 317.810 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

SKF-83959 is a drug used in scientific research that acts as an atypical dopamine receptor D1 agonist, acting as an agonist at phosphatidylinositol-linked D1 receptors and D1/D2-heteromers, but an antagonist at other subtypes.[1][2][3][4][5][6][7][8]


  1. ^ Jin LQ, Goswami S, Cai G, Zhen X, Friedman E (April 2003). "SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain". Journal of Neurochemistry 85 (2): 378–86. PMID 12675914.  
  2. ^ Zhen X, Goswami S, Friedman E (April 2005). "The role of the phosphatidyinositol-linked D1 dopamine receptor in the pharmacology of SKF83959". Pharmacology, Biochemistry, and Behavior 80 (4): 597–601. doi:10.1016/j.pbb.2005.01.016. PMID 15820529.  
  3. ^ Zhang ZJ, Jiang XL, Zhang SE, Hough CJ, Li H, Chen JG, Zhen XC (2005). "The paradoxical effects of SKF83959, a novel dopamine D1-like receptor agonist, in the rat acoustic startle reflex paradigm". Neuroscience Letters 382 (1-2): 134–8. doi:10.1016/j.neulet.2005.03.001. PMID 15911136.  
  4. ^ Panchalingam S, Undie AS (2005). "Physicochemical modulation of agonist-induced [35s]GTPgammaS binding: implications for coexistence of multiple functional conformations of dopamine D1-like receptors". Journal of Receptor and Signal Transduction Research 25 (2): 125–46. doi:10.1080/10799890500184948. PMID 16149770.  
  5. ^ Rashid AJ, So CH, Kong MM, Furtak T, El-Ghundi M, Cheng R, O'Dowd BF, George SR (January 2007). "D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum". Proceedings of the National Academy of Sciences of the United States of America 104 (2): 654–9. doi:10.1073/pnas.0604049104. PMID 17194762.  
  6. ^ Kuroiwa M, Bateup HS, Shuto T, Higashi H, Tanaka M, Nishi A (November 2008). "Regulation of DARPP-32 phosphorylation by three distinct dopamine D1-like receptor signaling pathways in the neostriatum". Journal of Neurochemistry 107 (4): 1014–26. doi:10.1111/j.1471-4159.2008.05702.x. PMID 18823371.  
  7. ^ Liu J, Wang W, Wang F, Cai F, Hu ZL, Yang YJ, Chen J, Chen JG (August 2009). "Phosphatidylinositol-linked novel D(1) dopamine receptor facilitates long-term depression in rat hippocampal CA1 synapses". Neuropharmacology 57 (2): 164–71. doi:10.1016/j.neuropharm.2009.05.001. PMID 19465033.  
  8. ^ Zhang X, Zhou Z, Wang D, Li A, Yin Y, Gu X, Ding F, Zhen X, Zhou J (June 2009). "Activation of phosphatidylinositol-linked D1-like receptor modulates FGF-2 expression in astrocytes via IP3-dependent Ca2+ signaling". The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 29 (24): 7766–75. doi:10.1523/JNEUROSCI.0389-09.2009. PMID 19535588.  


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