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SLC10A2: Wikis


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Solute carrier family 10 (sodium/bile acid cotransporter family), member 2
Symbols SLC10A2; ASBT; ISBT; NTCP2
External IDs OMIM601295 MGI1201406 HomoloGene390 GeneCards: SLC10A2 Gene
RNA expression pattern
PBB GE SLC10A2 207095 at tn.png
More reference expression data
Species Human Mouse
Entrez 6555 20494
Ensembl ENSG00000125255 ENSMUSG00000023073
UniProt Q12908 Q0VBB8
RefSeq (mRNA) NM_000452 NM_011388
RefSeq (protein) NP_000443 NP_035518
Location (UCSC) Chr 13:
102.49 - 102.52 Mb
Chr 8:
5.09 - 5.11 Mb
PubMed search [1] [2]

Ileal sodium/bile acid cotransporter is a protein that in humans is encoded by the SLC10A2 gene.[1][2]

See also


  1. ^ Wong MH, Rao PN, Pettenati MJ, Dawson PA (Sep 1996). "Localization of the ileal sodium-bile acid cotransporter gene (SLC10A2) to human chromosome 13q33". Genomics 33 (3): 538-40. doi:10.1006/geno.1996.0233. PMID 8661017.  
  2. ^ "Entrez Gene: SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2".  

Further reading

  • Shneider BL (2001). "Intestinal bile acid transport: biology, physiology, and pathophysiology.". J. Pediatr. Gastroenterol. Nutr. 32 (4): 407–17. doi:10.1097/00005176-200104000-00002. PMID 11396803.  
  • Balakrishnan A, Polli JE (2006). "Apical sodium dependent bile acid transporter (ASBT, SLC10A2): a potential prodrug target.". Mol. Pharm. 3 (3): 223–30. doi:10.1021/mp060022d. PMID 16749855.  
  • Wong MH, Oelkers P, Dawson PA (1995). "Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity.". J. Biol. Chem. 270 (45): 27228–34. doi:10.1074/jbc.270.45.27228. PMID 7592981.  
  • Oelkers P, Kirby LC, Heubi JE, Dawson PA (1997). "Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2).". J. Clin. Invest. 99 (8): 1880–7. doi:10.1172/JCI119355. PMID 9109432.  
  • Craddock AL, Love MW, Daniel RW, et al. (1998). "Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter.". Am. J. Physiol. 274 (1 Pt 1): G157–69. PMID 9458785.  
  • Montagnani M, Love MW, Rössel P, et al. (2002). "Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption.". Scand. J. Gastroenterol. 36 (10): 1077–80. doi:10.1080/003655201750422693. PMID 11589382.  
  • Love MW, Craddock AL, Angelin B, et al. (2002). "Analysis of the ileal bile acid transporter gene, SLC10A2, in subjects with familial hypertriglyceridemia.". Arterioscler. Thromb. Vasc. Biol. 21 (12): 2039–45. doi:10.1161/hq1201.100262. PMID 11742882.  
  • Jung D, Fried M, Kullak-Ublick GA (2002). "Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha.". J. Biol. Chem. 277 (34): 30559–66. doi:10.1074/jbc.M203511200. PMID 12055195.  
  • Zelcer N, Saeki T, Bot I, et al. (2003). "Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter.". Biochem. J. 369 (Pt 1): 23–30. doi:10.1042/BJ20021081. PMID 12220224.  
  • Chumakov I, Blumenfeld M, Guerassimenko O, et al. (2002). "Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia.". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13675–80. doi:10.1073/pnas.182412499. PMID 12364586.  
  • Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMID 15057823.  
  • Neimark E, Chen F, Li X, Shneider BL (2004). "Bile acid-induced negative feedback regulation of the human ileal bile acid transporter.". Hepatology 40 (1): 149–56. doi:10.1002/hep.20295. PMID 15239098.  
  • Xia X, Roundtree M, Merikhi A, et al. (2004). "Degradation of the apical sodium-dependent bile acid transporter by the ubiquitin-proteasome pathway in cholangiocytes.". J. Biol. Chem. 279 (43): 44931–7. doi:10.1074/jbc.M400969200. PMID 15304498.  
  • Zhang EY, Phelps MA, Banerjee A, et al. (2004). "Topology scanning and putative three-dimensional structure of the extracellular binding domains of the apical sodium-dependent bile acid transporter (SLC10A2).". Biochemistry 43 (36): 11380–92. doi:10.1021/bi049270a. PMID 15350125.  
  • Banerjee A, Ray A, Chang C, Swaan PW (2005). "Site-directed mutagenesis and use of bile acid-MTS conjugates to probe the role of cysteines in the human apical sodium-dependent bile acid transporter (SLC10A2).". Biochemistry 44 (24): 8908–17. doi:10.1021/bi050553s. PMID 15952798.  
  • Nakahara M, Furuya N, Takagaki K, et al. (2006). "Ileal bile acid-binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine.". J. Biol. Chem. 280 (51): 42283–9. doi:10.1074/jbc.M507454200. PMID 16230354.  
  • Bergheim I, Harsch S, Mueller O, et al. (2006). "Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers.". J. Lipid Res. 47 (1): 42–50. doi:10.1194/jlr.M500215-JLR200. PMID 16237211.  
  • Banerjee A, Swaan PW (2006). "Membrane topology of human ASBT (SLC10A2) determined by dual label epitope insertion scanning mutagenesis. New evidence for seven transmembrane domains.". Biochemistry 45 (3): 943–53. doi:10.1021/bi052202j. PMID 16411770.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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