The Full Wiki

More info on SLC10A2

SLC10A2: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Solute carrier family 10 (sodium/bile acid cotransporter family), member 2
Identifiers
Symbols SLC10A2; ASBT; ISBT; NTCP2
External IDs OMIM601295 MGI1201406 HomoloGene390 GeneCards: SLC10A2 Gene
RNA expression pattern
PBB GE SLC10A2 207095 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6555 20494
Ensembl ENSG00000125255 ENSMUSG00000023073
UniProt Q12908 Q0VBB8
RefSeq (mRNA) NM_000452 NM_011388
RefSeq (protein) NP_000443 NP_035518
Location (UCSC) Chr 13:
102.49 - 102.52 Mb
Chr 8:
5.09 - 5.11 Mb
PubMed search [1] [2]

Ileal sodium/bile acid cotransporter is a protein that in humans is encoded by the SLC10A2 gene.[1][2]

See also

References

  1. ^ Wong MH, Rao PN, Pettenati MJ, Dawson PA (Sep 1996). "Localization of the ileal sodium-bile acid cotransporter gene (SLC10A2) to human chromosome 13q33". Genomics 33 (3): 538-40. doi:10.1006/geno.1996.0233. PMID 8661017.  
  2. ^ "Entrez Gene: SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6555.  

Further reading

  • Shneider BL (2001). "Intestinal bile acid transport: biology, physiology, and pathophysiology.". J. Pediatr. Gastroenterol. Nutr. 32 (4): 407–17. doi:10.1097/00005176-200104000-00002. PMID 11396803.  
  • Balakrishnan A, Polli JE (2006). "Apical sodium dependent bile acid transporter (ASBT, SLC10A2): a potential prodrug target.". Mol. Pharm. 3 (3): 223–30. doi:10.1021/mp060022d. PMID 16749855.  
  • Wong MH, Oelkers P, Dawson PA (1995). "Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity.". J. Biol. Chem. 270 (45): 27228–34. doi:10.1074/jbc.270.45.27228. PMID 7592981.  
  • Oelkers P, Kirby LC, Heubi JE, Dawson PA (1997). "Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2).". J. Clin. Invest. 99 (8): 1880–7. doi:10.1172/JCI119355. PMID 9109432.  
  • Craddock AL, Love MW, Daniel RW, et al. (1998). "Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter.". Am. J. Physiol. 274 (1 Pt 1): G157–69. PMID 9458785.  
  • Montagnani M, Love MW, Rössel P, et al. (2002). "Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption.". Scand. J. Gastroenterol. 36 (10): 1077–80. doi:10.1080/003655201750422693. PMID 11589382.  
  • Love MW, Craddock AL, Angelin B, et al. (2002). "Analysis of the ileal bile acid transporter gene, SLC10A2, in subjects with familial hypertriglyceridemia.". Arterioscler. Thromb. Vasc. Biol. 21 (12): 2039–45. doi:10.1161/hq1201.100262. PMID 11742882.  
  • Jung D, Fried M, Kullak-Ublick GA (2002). "Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha.". J. Biol. Chem. 277 (34): 30559–66. doi:10.1074/jbc.M203511200. PMID 12055195.  
  • Zelcer N, Saeki T, Bot I, et al. (2003). "Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter.". Biochem. J. 369 (Pt 1): 23–30. doi:10.1042/BJ20021081. PMID 12220224.  
  • Chumakov I, Blumenfeld M, Guerassimenko O, et al. (2002). "Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia.". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13675–80. doi:10.1073/pnas.182412499. PMID 12364586.  
  • Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMID 15057823.  
  • Neimark E, Chen F, Li X, Shneider BL (2004). "Bile acid-induced negative feedback regulation of the human ileal bile acid transporter.". Hepatology 40 (1): 149–56. doi:10.1002/hep.20295. PMID 15239098.  
  • Xia X, Roundtree M, Merikhi A, et al. (2004). "Degradation of the apical sodium-dependent bile acid transporter by the ubiquitin-proteasome pathway in cholangiocytes.". J. Biol. Chem. 279 (43): 44931–7. doi:10.1074/jbc.M400969200. PMID 15304498.  
  • Zhang EY, Phelps MA, Banerjee A, et al. (2004). "Topology scanning and putative three-dimensional structure of the extracellular binding domains of the apical sodium-dependent bile acid transporter (SLC10A2).". Biochemistry 43 (36): 11380–92. doi:10.1021/bi049270a. PMID 15350125.  
  • Banerjee A, Ray A, Chang C, Swaan PW (2005). "Site-directed mutagenesis and use of bile acid-MTS conjugates to probe the role of cysteines in the human apical sodium-dependent bile acid transporter (SLC10A2).". Biochemistry 44 (24): 8908–17. doi:10.1021/bi050553s. PMID 15952798.  
  • Nakahara M, Furuya N, Takagaki K, et al. (2006). "Ileal bile acid-binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine.". J. Biol. Chem. 280 (51): 42283–9. doi:10.1074/jbc.M507454200. PMID 16230354.  
  • Bergheim I, Harsch S, Mueller O, et al. (2006). "Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers.". J. Lipid Res. 47 (1): 42–50. doi:10.1194/jlr.M500215-JLR200. PMID 16237211.  
  • Banerjee A, Swaan PW (2006). "Membrane topology of human ASBT (SLC10A2) determined by dual label epitope insertion scanning mutagenesis. New evidence for seven transmembrane domains.". Biochemistry 45 (3): 943–53. doi:10.1021/bi052202j. PMID 16411770.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message