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Solute carrier family 12 (potassium/chloride transporters), member 7
Identifiers
Symbols SLC12A7; DKFZP434F076; KCC4
External IDs OMIM604879 MGI1342283 HomoloGene21312 GeneCards: SLC12A7 Gene
RNA expression pattern
PBB GE SLC12A7 218066 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10723 20499
Ensembl ENSG00000113504 ENSMUSG00000017756
UniProt Q9Y666 Q3TB23
RefSeq (mRNA) NM_006598 NM_011390
RefSeq (protein) NP_006589 NP_035520
Location (UCSC) Chr 5:
1.1 - 1.17 Mb
Chr 13:
74.2 - 74.28 Mb
PubMed search [1] [2]

Solute carrier family 12 member 7 is a protein that in humans is encoded by the SLC12A7 gene.[1][2]

See also

References

  1. ^ Mount DB, Mercado A, Song L, Xu J, George AL Jr, Delpire E, Gamba G (Jul 1999). "Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family". J Biol Chem 274 (23): 16355-62. PMID 10347194.  
  2. ^ "Entrez Gene: SLC12A7 solute carrier family 12 (potassium/chloride transporters), member 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10723.  

Further reading

  • Mercado A, Song L, Vazquez N, et al. (2000). "Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4.". J. Biol. Chem. 275 (39): 30326–34. doi:10.1074/jbc.M003112200. PMID 10913127.  
  • Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen.". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.  
  • Boettger T, Hübner CA, Maier H, et al. (2002). "Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4.". Nature 416 (6883): 874–8. doi:10.1038/416874a. PMID 11976689.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Bräuer M, Frei E, Claes L, et al. (2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts.". Am. J. Physiol., Cell Physiol. 285 (1): C22–30. doi:10.1152/ajpcell.00289.2002. PMID 12637262.  
  • Karadsheh MF, Byun N, Mount DB, Delpire E (2004). "Localization of the KCC4 potassium-chloride cotransporter in the nervous system.". Neuroscience 123 (2): 381–91. doi:10.1016/j.neuroscience.2003.10.004. PMID 14698746.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Shen MR, Lin AC, Hsu YM, et al. (2004). "Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells.". J. Biol. Chem. 279 (38): 40017–25. doi:10.1074/jbc.M406706200. PMID 15262997.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Hsu YM, Chou CY, Chen HH, et al. (2007). "IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness.". J. Cell. Physiol. 210 (3): 626–36. doi:10.1002/jcp.20859. PMID 17133354.  
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