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SLC12A7: Wikis


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Solute carrier family 12 (potassium/chloride transporters), member 7
Symbols SLC12A7; DKFZP434F076; KCC4
External IDs OMIM604879 MGI1342283 HomoloGene21312 GeneCards: SLC12A7 Gene
RNA expression pattern
PBB GE SLC12A7 218066 at tn.png
More reference expression data
Species Human Mouse
Entrez 10723 20499
Ensembl ENSG00000113504 ENSMUSG00000017756
UniProt Q9Y666 Q3TB23
RefSeq (mRNA) NM_006598 NM_011390
RefSeq (protein) NP_006589 NP_035520
Location (UCSC) Chr 5:
1.1 - 1.17 Mb
Chr 13:
74.2 - 74.28 Mb
PubMed search [1] [2]

Solute carrier family 12 member 7 is a protein that in humans is encoded by the SLC12A7 gene.[1][2]

See also


  1. ^ Mount DB, Mercado A, Song L, Xu J, George AL Jr, Delpire E, Gamba G (Jul 1999). "Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family". J Biol Chem 274 (23): 16355-62. PMID 10347194.  
  2. ^ "Entrez Gene: SLC12A7 solute carrier family 12 (potassium/chloride transporters), member 7".  

Further reading

  • Mercado A, Song L, Vazquez N, et al. (2000). "Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4.". J. Biol. Chem. 275 (39): 30326–34. doi:10.1074/jbc.M003112200. PMID 10913127.  
  • Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen.". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.  
  • Boettger T, Hübner CA, Maier H, et al. (2002). "Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4.". Nature 416 (6883): 874–8. doi:10.1038/416874a. PMID 11976689.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Bräuer M, Frei E, Claes L, et al. (2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts.". Am. J. Physiol., Cell Physiol. 285 (1): C22–30. doi:10.1152/ajpcell.00289.2002. PMID 12637262.  
  • Karadsheh MF, Byun N, Mount DB, Delpire E (2004). "Localization of the KCC4 potassium-chloride cotransporter in the nervous system.". Neuroscience 123 (2): 381–91. doi:10.1016/j.neuroscience.2003.10.004. PMID 14698746.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Shen MR, Lin AC, Hsu YM, et al. (2004). "Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells.". J. Biol. Chem. 279 (38): 40017–25. doi:10.1074/jbc.M406706200. PMID 15262997.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Hsu YM, Chou CY, Chen HH, et al. (2007). "IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness.". J. Cell. Physiol. 210 (3): 626–36. doi:10.1002/jcp.20859. PMID 17133354.  


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