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Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3
Symbols SLC13A3; NADC3; SDCT2
External IDs OMIM606411 MGI2149635 HomoloGene11266 GeneCards: SLC13A3 Gene
RNA expression pattern
PBB GE SLC13A3 205243 at tn.png
PBB GE SLC13A3 205244 s at tn.png
More reference expression data
Species Human Mouse
Entrez 64849 114644
Ensembl ENSG00000158296 ENSMUSG00000018459
UniProt Q8WWT9 Q3UUJ6
RefSeq (mRNA) NM_001011554 NM_054055
RefSeq (protein) NP_001011554 NP_473396
Location (UCSC) Chr 20:
44.62 - 44.73 Mb
Chr 2:
165.1 - 165.16 Mb
PubMed search [1] [2]

Solute carrier family 13 member 3 is a protein that in humans is encoded by the SLC13A3 gene.[1][2][3]

Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.[3]

See also


  1. ^ Wang H, Fei YJ, Kekuda R, Yang-Feng TL, Devoe LD, Leibach FH, Prasad PD, Ganapathy V (Jun 2000). "Structure, function, and genomic organization of human Na(+)-dependent high-affinity dicarboxylate transporter". Am J Physiol Cell Physiol 278 (5): C1019-30. PMID 10794676.  
  2. ^ Huang W, Wang H, Kekuda R, Fei YJ, Friedrich A, Wang J, Conway SJ, Cameron RS, Leibach FH, Ganapathy V (Nov 2000). "Transport of N-acetylaspartate by the Na(+)-dependent high-affinity dicarboxylate transporter NaDC3 and its relevance to the expression of the transporter in the brain". J Pharmacol Exp Ther 295 (1): 392-403. PMID 10992006.  
  3. ^ a b "Entrez Gene: SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3".  

Further reading

  • Markovich D, Murer H (2004). "The SLC13 gene family of sodium sulphate/carboxylate cotransporters.". Pflugers Arch. 447 (5): 594–602. doi:10.1007/s00424-003-1128-6. PMID 12915942.  
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Burckhardt BC, Lorenz J, Kobbe C, Burckhardt G (2005). "Substrate specificity of the human renal sodium dicarboxylate cotransporter, hNaDC-3, under voltage-clamp conditions.". Am. J. Physiol. Renal Physiol. 288 (4): F792–9. doi:10.1152/ajprenal.00360.2004. PMID 15561973.  
  • Bai X, Chen X, Feng Z, et al. (2006). "Identification of basolateral membrane targeting signal of human sodium-dependent dicarboxylate transporter 3.". J. Cell. Physiol. 206 (3): 821–30. doi:10.1002/jcp.20553. PMID 16331647.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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