The Full Wiki

More info on SLC16A1

SLC16A1: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
Identifiers
Symbols SLC16A1; MCT1; FLJ36745; MCT; MGC44475
External IDs OMIM600682 MGI106013 HomoloGene20662 GeneCards: SLC16A1 Gene
RNA expression pattern
PBB GE SLC16A1 202236 s at tn.png
PBB GE SLC16A1 202234 s at tn.png
PBB GE SLC16A1 202235 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6566 20501
Ensembl ENSG00000155380 ENSMUSG00000032902
UniProt P53985 Q3TIU1
RefSeq (mRNA) NM_003051 NM_009196
RefSeq (protein) NP_003042 NP_033222
Location (UCSC) Chr 1:
113.26 - 113.3 Mb
Chr 3:
104.77 - 104.79 Mb
PubMed search [1] [2]

Monocarboxylate transporter 1 is a protein that in humans is encoded by the SLC16A1 gene.[1][2][3]

References

  1. ^ Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (Apr 1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell 76 (5): 865-73. PMID 8124722.  
  2. ^ Garcia CK, Li X, Luna J, Francke U (Feb 1995). "cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12". Genomics 23 (2): 500-3. doi:10.1006/geno.1994.1532. PMID 7835905.  
  3. ^ "Entrez Gene: SLC16A1 solute carrier family 16, member 1 (monocarboxylic acid transporter 1)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6566.  

Further reading

  • Bonen A (2002). "The expression of lactate transporters (MCT1 and MCT4) in heart and muscle.". Eur. J. Appl. Physiol. 86 (1): 6–11. doi:10.1007/s004210100516. PMID 11820324.  
  • Halestrap AP, Meredith D (2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.". Pflugers Arch. 447 (5): 619–28. doi:10.1007/s00424-003-1067-2. PMID 12739169.  
  • Kim CM, Goldstein JL, Brown MS (1992). "cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function.". J. Biol. Chem. 267 (32): 23113–21. PMID 1429658.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Ritzhaupt A, Wood IS, Ellis A, et al. (1999). "Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactate as well as butyrate.". J. Physiol. (Lond.) 513 ( Pt 3): 719–32. PMID 9824713.  
  • Rahman B, Schneider HP, Bröer A, et al. (1999). "Helix 8 and helix 10 are involved in substrate recognition in the rat monocarboxylate transporter MCT1.". Biochemistry 38 (35): 11577–84. doi:10.1021/bi990973f. PMID 10471310.  
  • Brooks GA, Brown MA, Butz CE, et al. (1999). "Cardiac and skeletal muscle mitochondria have a monocarboxylate transporter MCT1.". J. Appl. Physiol. 87 (5): 1713–8. PMID 10562613.  
  • Merezhinskaya N, Fishbein WN, Davis JI, Foellmer JW (2000). "Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport.". Muscle Nerve 23 (1): 90–7. doi:10.1002/(SICI)1097-4598(200001)23:1<90::AID-MUS12>3.0.CO;2-M. PMID 10590411.  
  • Kirk P, Wilson MC, Heddle C, et al. (2000). "CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression.". Embo J. 19 (15): 3896–904. doi:10.1093/emboj/19.15.3896. PMID 10921872.  
  • Cuff MA, Lambert DW, Shirazi-Beechey SP (2002). "Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1.". J. Physiol. (Lond.) 539 (Pt 2): 361–71. doi:10.1113/jphysiol.2001.014241. PMID 11882670.  
  • Cuff MA, Shirazi-Beechey SP (2002). "The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis.". Biochem. Biophys. Res. Commun. 292 (4): 1048–56. doi:10.1006/bbrc.2002.6763. PMID 11944921.  
  • Lambert DW, Wood IS, Ellis A, Shirazi-Beechey SP (2002). "Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy.". Br. J. Cancer 86 (8): 1262–9. doi:10.1038/sj.bjc.6600264. PMID 11953883.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Zhang GZ, Huang GJ, Li WL, et al. (2002). "[Effect of co-inhibition of MCT1 gene and NHE1 gene on proliferation and growth of human lung adenocarcinoma cells]". Ai Zheng 21 (7): 719–23. PMID 12479094.  
  • Philp NJ, Wang D, Yoon H, Hjelmeland LM (2003). "Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells.". Invest. Ophthalmol. Vis. Sci. 44 (4): 1716–21. doi:10.1167/iovs.02-0287. PMID 12657613.  
  • Asada K, Miyamoto K, Fukutomi T, et al. (2003). "Reduced expression of GNA11 and silencing of MCT1 in human breast cancers.". Oncology 64 (4): 380–8. doi:10.1159/000070297. PMID 12759536.  
Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message