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SLC16A1: Wikis


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From Wikipedia, the free encyclopedia

Solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
Symbols SLC16A1; MCT1; FLJ36745; MCT; MGC44475
External IDs OMIM600682 MGI106013 HomoloGene20662 GeneCards: SLC16A1 Gene
RNA expression pattern
PBB GE SLC16A1 202236 s at tn.png
PBB GE SLC16A1 202234 s at tn.png
PBB GE SLC16A1 202235 at tn.png
More reference expression data
Species Human Mouse
Entrez 6566 20501
Ensembl ENSG00000155380 ENSMUSG00000032902
UniProt P53985 Q3TIU1
RefSeq (mRNA) NM_003051 NM_009196
RefSeq (protein) NP_003042 NP_033222
Location (UCSC) Chr 1:
113.26 - 113.3 Mb
Chr 3:
104.77 - 104.79 Mb
PubMed search [1] [2]

Monocarboxylate transporter 1 is a protein that in humans is encoded by the SLC16A1 gene.[1][2][3]


  1. ^ Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (Apr 1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell 76 (5): 865-73. PMID 8124722.  
  2. ^ Garcia CK, Li X, Luna J, Francke U (Feb 1995). "cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12". Genomics 23 (2): 500-3. doi:10.1006/geno.1994.1532. PMID 7835905.  
  3. ^ "Entrez Gene: SLC16A1 solute carrier family 16, member 1 (monocarboxylic acid transporter 1)".  

Further reading

  • Bonen A (2002). "The expression of lactate transporters (MCT1 and MCT4) in heart and muscle.". Eur. J. Appl. Physiol. 86 (1): 6–11. doi:10.1007/s004210100516. PMID 11820324.  
  • Halestrap AP, Meredith D (2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond.". Pflugers Arch. 447 (5): 619–28. doi:10.1007/s00424-003-1067-2. PMID 12739169.  
  • Kim CM, Goldstein JL, Brown MS (1992). "cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function.". J. Biol. Chem. 267 (32): 23113–21. PMID 1429658.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Ritzhaupt A, Wood IS, Ellis A, et al. (1999). "Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactate as well as butyrate.". J. Physiol. (Lond.) 513 ( Pt 3): 719–32. PMID 9824713.  
  • Rahman B, Schneider HP, Bröer A, et al. (1999). "Helix 8 and helix 10 are involved in substrate recognition in the rat monocarboxylate transporter MCT1.". Biochemistry 38 (35): 11577–84. doi:10.1021/bi990973f. PMID 10471310.  
  • Brooks GA, Brown MA, Butz CE, et al. (1999). "Cardiac and skeletal muscle mitochondria have a monocarboxylate transporter MCT1.". J. Appl. Physiol. 87 (5): 1713–8. PMID 10562613.  
  • Merezhinskaya N, Fishbein WN, Davis JI, Foellmer JW (2000). "Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport.". Muscle Nerve 23 (1): 90–7. doi:10.1002/(SICI)1097-4598(200001)23:1<90::AID-MUS12>3.0.CO;2-M. PMID 10590411.  
  • Kirk P, Wilson MC, Heddle C, et al. (2000). "CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression.". Embo J. 19 (15): 3896–904. doi:10.1093/emboj/19.15.3896. PMID 10921872.  
  • Cuff MA, Lambert DW, Shirazi-Beechey SP (2002). "Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1.". J. Physiol. (Lond.) 539 (Pt 2): 361–71. doi:10.1113/jphysiol.2001.014241. PMID 11882670.  
  • Cuff MA, Shirazi-Beechey SP (2002). "The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis.". Biochem. Biophys. Res. Commun. 292 (4): 1048–56. doi:10.1006/bbrc.2002.6763. PMID 11944921.  
  • Lambert DW, Wood IS, Ellis A, Shirazi-Beechey SP (2002). "Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy.". Br. J. Cancer 86 (8): 1262–9. doi:10.1038/sj.bjc.6600264. PMID 11953883.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Zhang GZ, Huang GJ, Li WL, et al. (2002). "[Effect of co-inhibition of MCT1 gene and NHE1 gene on proliferation and growth of human lung adenocarcinoma cells]". Ai Zheng 21 (7): 719–23. PMID 12479094.  
  • Philp NJ, Wang D, Yoon H, Hjelmeland LM (2003). "Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells.". Invest. Ophthalmol. Vis. Sci. 44 (4): 1716–21. doi:10.1167/iovs.02-0287. PMID 12657613.  
  • Asada K, Miyamoto K, Fukutomi T, et al. (2003). "Reduced expression of GNA11 and silencing of MCT1 in human breast cancers.". Oncology 64 (4): 380–8. doi:10.1159/000070297. PMID 12759536.  


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