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SLC1A4: Wikis


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Solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
Symbols SLC1A4; ASCT1; SATT
External IDs OMIM600229 MGI2135601 HomoloGene20655 GeneCards: SLC1A4 Gene
RNA expression pattern
PBB GE SLC1A4 209610 s at tn.png
PBB GE SLC1A4 209611 s at tn.png
PBB GE SLC1A4 212810 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6509 55963
Ensembl ENSG00000115902 ENSMUSG00000020142
UniProt P43007 Q3US35
RefSeq (mRNA) NM_003038 NM_018861
RefSeq (protein) NP_003029 NP_061349
Location (UCSC) Chr 2:
65.07 - 65.1 Mb
Chr 11:
20.2 - 20.23 Mb
PubMed search [1] [2]

Neutral amino acid transporter A is a protein that in humans is encoded by the SLC1A4 gene.[1][2][3] In melanocytic cells SLC1A4 gene expression may be regulated by MITF[4].

See also


  1. ^ Hofmann K, Duker M, Fink T, Lichter P, Stoffel W (Apr 1995). "Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15". Genomics 24 (1): 20-6. doi:10.1006/geno.1994.1577. PMID 7896285.  
  2. ^ Zerangue N, Kavanaugh MP (Dec 1996). "ASCT-1 is a neutral amino acid exchanger with chloride channel activity". J Biol Chem 271 (45): 27991-4. PMID 8910405.  
  3. ^ "Entrez Gene: SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4".  
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.  

Further reading

  • Arriza JL, Kavanaugh MP, Fairman WA, et al. (1993). "Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family.". J. Biol. Chem. 268 (21): 15329–32. PMID 8101838.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Shafqat S, Tamarappoo BK, Kilberg MS, et al. (1993). "Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters.". J. Biol. Chem. 268 (21): 15351–5. PMID 8340364.  
  • Tamarappoo BK, McDonald KK, Kilberg MS (1996). "Expressed human hippocampal ASCT1 amino acid transporter exhibits a pH-dependent change in substrate specificity.". Biochim. Biophys. Acta 1279 (2): 131–6. doi:10.1016/0005-2736(95)00259-6. PMID 8603078.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Marin M, Tailor CS, Nouri A, Kabat D (2000). "Sodium-dependent neutral amino acid transporter type 1 is an auxiliary receptor for baboon endogenous retrovirus.". J. Virol. 74 (17): 8085–93. doi:10.1128/JVI.74.17.8085-8093.2000. PMID 10933718.  
  • Younes M, Pathak M, Finnie D, et al. (2001). "Expression of the neutral amino acids transporter ASCT1 in esophageal carcinomas.". Anticancer Res. 20 (5C): 3775–9. PMID 11268453.  
  • Pinilla J, Barber A, Lostao MP (2002). "Active transport of alanine by the neutral amino-acid exchanger ASCT1.". Can. J. Physiol. Pharmacol. 79 (12): 1023–9. doi:10.1139/cjpp-79-12-1023. PMID 11824937.  
  • Lavillette D, Marin M, Ruggieri A, et al. (2002). "The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors.". J. Virol. 76 (13): 6442–52. doi:10.1128/JVI.76.13.6442-6452.2002. PMID 12050356.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Marin M, Lavillette D, Kelly SM, Kabat D (2003). "N-linked glycosylation and sequence changes in a critical negative control region of the ASCT1 and ASCT2 neutral amino acid transporters determine their retroviral receptor functions.". J. Virol. 77 (5): 2936–45. doi:10.1128/JVI.77.5.2936-2945.2003. PMID 12584318.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.  
  • Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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