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SLC20A1: Wikis


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From Wikipedia, the free encyclopedia

Solute carrier family 20 (phosphate transporter), member 1
Symbols SLC20A1; PIT1; DKFZp686J2397; FLJ41426; GLVR1; Glvr-1; PiT-1
External IDs OMIM137570 MGI108392 HomoloGene38049 GeneCards: SLC20A1 Gene
RNA expression pattern
PBB GE SLC20A1 201920 at tn.png
More reference expression data
Species Human Mouse
Entrez 6574 20515
Ensembl ENSG00000144136 ENSMUSG00000027397
UniProt Q8WUM9 Q61609
RefSeq (mRNA) NM_005415 NM_015747
RefSeq (protein) NP_005406 NP_056562
Location (UCSC) Chr 2:
113.12 - 113.14 Mb
Chr 2:
128.89 - 128.9 Mb
PubMed search [1] [2]

Sodium-dependent phosphate transporter 1 is a protein that in humans is encoded by the SLC20A1 gene.[1][2]

Retrovirus receptors allow infection of human and murine cells by various retroviruses. The receptors that have been identified at the molecular level include CD4 (MIM 186940) for human immunodeficiency virus, Rec1 for murine ecotropic virus, and GLVR1 for gibbon ape leukemia virus (see MIM 182090). These 3 proteins show no homology to one another at the DNA or protein level. GLVR1 is a sodium-dependent phosphate symporter.[supplied by OMIM][2]

See also


Further reading

  • Takeuchi Y, Vile RG, Simpson G, et al. (1992). "Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus.". J. Virol. 66 (2): 1219–22. PMID 1309898.  
  • Johann SV, Gibbons JJ, O'Hara B (1992). "GLVR1, a receptor for gibbon ape leukemia virus, is homologous to a phosphate permease of Neurospora crassa and is expressed at high levels in the brain and thymus.". J. Virol. 66 (3): 1635–40. PMID 1531369.  
  • Kaelbling M, Eddy R, Shows TB, et al. (1991). "Localization of the human gene allowing infection by gibbon ape leukemia virus to human chromosome region 2q11-q14 and to the homologous region on mouse chromosome 2.". J. Virol. 65 (4): 1743–7. PMID 1672162.  
  • O'Hara B, Johann SV, Klinger HP, et al. (1991). "Characterization of a human gene conferring sensitivity to infection by gibbon ape leukemia virus.". Cell Growth Differ. 1 (3): 119–27. PMID 2078500.  
  • Olah Z, Lehel C, Anderson WB, et al. (1994). "The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter.". J. Biol. Chem. 269 (41): 25426–31. PMID 7929240.  
  • Miller DG, Miller AD (1994). "A family of retroviruses that utilize related phosphate transporters for cell entry.". J. Virol. 68 (12): 8270–6. PMID 7966619.  
  • Johann SV, van Zeijl M, Cekleniak J, O'Hara B (1993). "Definition of a domain of GLVR1 which is necessary for infection by gibbon ape leukemia virus and which is highly polymorphic between species.". J. Virol. 67 (11): 6733–6. PMID 8411375.  
  • Tatsumi S, Segawa H, Morita K, et al. (1998). "Molecular cloning and hormonal regulation of PiT-1, a sodium-dependent phosphate cotransporter from rat parathyroid glands.". Endocrinology 139 (4): 1692–9. doi:10.1210/en.139.4.1692. PMID 9528951.  
  • Palmer G, Manen D, Bonjour JP, Caverzasio J (1999). "Characterization of the human Glvr-1 phosphate transporter/retrovirus receptor gene and promoter region.". Gene 226 (1): 25–33. doi:10.1016/S0378-1119(98)00572-1. PMID 9889306.  
  • Jono S, McKee MD, Murry CE, et al. (2000). "Phosphate regulation of vascular smooth muscle cell calcification.". Circ. Res. 87 (7): E10–7. PMID 11009570.  
  • Farrell KB, Russ JL, Murthy RK, Eiden MV (2002). "Reassessing the role of region A in Pit1-mediated viral entry.". J. Virol. 76 (15): 7683–93. doi:10.1128/JVI.76.15.7683-7693.2002. PMID 12097582.  
  • Bottger P, Pedersen L (2003). "Two highly conserved glutamate residues critical for type III sodium-dependent phosphate transport revealed by uncoupling transport function from retroviral receptor function.". J. Biol. Chem. 277 (45): 42741–7. doi:10.1074/jbc.M207096200. PMID 12205090.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.". Oncogene 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Cecil DL, Rose DM, Terkeltaub R, Liu-Bryan R (2005). "Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes.". Arthritis Rheum. 52 (1): 144–54. doi:10.1002/art.20748. PMID 15641067.  
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.  
  • Li X, Yang HY, Giachelli CM (2006). "Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification.". Circ. Res. 98 (7): 905–12. doi:10.1161/01.RES.0000216409.20863.e7. PMID 16527991.  
  • Bøttger P, Hede SE, Grunnet M, et al. (2007). "Characterization of transport mechanisms and determinants critical for Na+-dependent Pi symport of the PiT family paralogs human PiT1 and PiT2.". Am. J. Physiol., Cell Physiol. 291 (6): C1377–87. doi:10.1152/ajpcell.00015.2006. PMID 16790504.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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