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SLC22A18: Wikis


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Solute carrier family 22 (organic cation transporter), member 18
Symbols SLC22A18; BWR1A; BWSCR1A; DKFZp667A184; HET; IMPT1; ITM; ORCTL2; SLC22A1L; TSSC5; p45-BWR1A
External IDs OMIM602631 MGI1336884 HomoloGene1918 GeneCards: SLC22A18 Gene
RNA expression pattern
PBB GE SLC22A18 204981 at tn.png
More reference expression data
Species Human Mouse
Entrez 5002 18400
Ensembl ENSG00000110628 ENSMUSG00000000154
UniProt Q96BI1 Q05DG8
RefSeq (mRNA) NM_002555 NM_001042760
RefSeq (protein) NP_002546 NP_001036225
Location (UCSC) Chr 11:
2.88 - 2.9 Mb
Chr 7:
143.28 - 143.31 Mb
PubMed search [1] [2]

Solute carrier family 22 member 18 is a protein that in humans is encoded by the SLC22A18 gene.[1][2][3]

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region as well as the transport of chloroquine- and quinidine-related compounds in the kidney. Two alternative transcripts encoding the same isoform have been described.[3]

See also


  1. ^ Dao D, Frank D, Qian N, O'Keefe D, Vosatka RJ, Walsh CP, Tycko B (May 1998). "IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes". Hum Mol Genet 7 (4): 597-608. PMID 9499412.  
  2. ^ Schwienbacher C, Sabbioni S, Campi M, Veronese A, Bernardi G, Menegatti A, Hatada I, Mukai T, Ohashi H, Barbanti-Brodano G, Croce CM, Negrini M (May 1998). "Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples". Proc Natl Acad Sci U S A 95 (7): 3873-8. PMID 9520460.  
  3. ^ a b "Entrez Gene: SLC22A18 solute carrier family 22 (organic cation transporter), member 18".  

Further reading

  • Akiyama S (2002). "[Mechanisms of drug resistance and reversal of the resistance]". Hum. Cell 14 (4): 257–60. PMID 11925925.  
  • Cooper PR, Smilinich NJ, Day CD, et al. (1998). "Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain.". Genomics 49 (1): 38–51. doi:10.1006/geno.1998.5221. PMID 9570947.  
  • Reece M, Prawitt D, Landers J, et al. (1998). "Functional characterization of ORCTL2--an organic cation transporter expressed in the renal proximal tubules.". FEBS Lett. 433 (3): 245–50. doi:10.1016/S0014-5793(98)00907-7. PMID 9744804.  
  • Lee MP, Reeves C, Schmitt A, et al. (1998). "Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5.". Cancer Res. 58 (18): 4155–9. PMID 9751628.  
  • Morisaki H, Hatada I, Morisaki T, Mukai T (1999). "A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice.". DNA Res. 5 (4): 235–40. doi:10.1093/dnares/5.4.235. PMID 9802569.  
  • Onyango P, Miller W, Lehoczky J, et al. (2001). "Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain.". Genome Res. 10 (11): 1697–710. doi:10.1101/gr.161800. PMID 11076855.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Yamada HY, Gorbsky GJ (2006). "Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105.". Oncogene 25 (9): 1330–9. doi:10.1038/sj.onc.1209167. PMID 16314844.  
  • Gallagher E, Mc Goldrick A, Chung WY, et al. (2006). "Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer.". Genomics 88 (1): 12–7. doi:10.1016/j.ygeno.2006.02.004. PMID 16624517.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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