The Full Wiki

More info on SLC22A18

SLC22A18: Wikis

Advertisements

Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.

Encyclopedia

From Wikipedia, the free encyclopedia

edit
Solute carrier family 22 (organic cation transporter), member 18
Identifiers
Symbols SLC22A18; BWR1A; BWSCR1A; DKFZp667A184; HET; IMPT1; ITM; ORCTL2; SLC22A1L; TSSC5; p45-BWR1A
External IDs OMIM602631 MGI1336884 HomoloGene1918 GeneCards: SLC22A18 Gene
RNA expression pattern
PBB GE SLC22A18 204981 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5002 18400
Ensembl ENSG00000110628 ENSMUSG00000000154
UniProt Q96BI1 Q05DG8
RefSeq (mRNA) NM_002555 NM_001042760
RefSeq (protein) NP_002546 NP_001036225
Location (UCSC) Chr 11:
2.88 - 2.9 Mb
Chr 7:
143.28 - 143.31 Mb
PubMed search [1] [2]

Solute carrier family 22 member 18 is a protein that in humans is encoded by the SLC22A18 gene.[1][2][3]

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region as well as the transport of chloroquine- and quinidine-related compounds in the kidney. Two alternative transcripts encoding the same isoform have been described.[3]

See also

References

  1. ^ Dao D, Frank D, Qian N, O'Keefe D, Vosatka RJ, Walsh CP, Tycko B (May 1998). "IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes". Hum Mol Genet 7 (4): 597-608. PMID 9499412.  
  2. ^ Schwienbacher C, Sabbioni S, Campi M, Veronese A, Bernardi G, Menegatti A, Hatada I, Mukai T, Ohashi H, Barbanti-Brodano G, Croce CM, Negrini M (May 1998). "Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples". Proc Natl Acad Sci U S A 95 (7): 3873-8. PMID 9520460.  
  3. ^ a b "Entrez Gene: SLC22A18 solute carrier family 22 (organic cation transporter), member 18". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5002.  

Further reading

  • Akiyama S (2002). "[Mechanisms of drug resistance and reversal of the resistance]". Hum. Cell 14 (4): 257–60. PMID 11925925.  
  • Cooper PR, Smilinich NJ, Day CD, et al. (1998). "Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain.". Genomics 49 (1): 38–51. doi:10.1006/geno.1998.5221. PMID 9570947.  
  • Reece M, Prawitt D, Landers J, et al. (1998). "Functional characterization of ORCTL2--an organic cation transporter expressed in the renal proximal tubules.". FEBS Lett. 433 (3): 245–50. doi:10.1016/S0014-5793(98)00907-7. PMID 9744804.  
  • Lee MP, Reeves C, Schmitt A, et al. (1998). "Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5.". Cancer Res. 58 (18): 4155–9. PMID 9751628.  
  • Morisaki H, Hatada I, Morisaki T, Mukai T (1999). "A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice.". DNA Res. 5 (4): 235–40. doi:10.1093/dnares/5.4.235. PMID 9802569.  
  • Onyango P, Miller W, Lehoczky J, et al. (2001). "Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain.". Genome Res. 10 (11): 1697–710. doi:10.1101/gr.161800. PMID 11076855.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Yamada HY, Gorbsky GJ (2006). "Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105.". Oncogene 25 (9): 1330–9. doi:10.1038/sj.onc.1209167. PMID 16314844.  
  • Gallagher E, Mc Goldrick A, Chung WY, et al. (2006). "Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer.". Genomics 88 (1): 12–7. doi:10.1016/j.ygeno.2006.02.004. PMID 16624517.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Advertisements

Advertisements






Got something to say? Make a comment.
Your name
Your email address
Message