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Solute carrier family 22 (extraneuronal monoamine transporter), member 3
Identifiers
Symbols SLC22A3; EMT; OCT3; EMTH
External IDs OMIM604842 MGI1333817 HomoloGene22630 GeneCards: SLC22A3 Gene
RNA expression pattern
PBB GE SLC22A3 205421 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6581 20519
Ensembl ENSG00000146477 ENSMUSG00000023828
UniProt O75751 Q547K2
RefSeq (mRNA) NM_021977 XM_977528
RefSeq (protein) NP_068812 XP_982622
Location (UCSC) Chr 6:
160.69 - 160.8 Mb
Chr 17:
12.26 - 12.35 Mb
PubMed search [1] [2]

Solute carrier family 22 member 3 is a protein that in humans is encoded by the SLC22A3 gene.[1][2][3]

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein.[3]

See also

References

  1. ^ Kekuda R, Prasad PD, Wu X, Wang H, Fei YJ, Leibach FH, Ganapathy V (Aug 1998). "Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta". J Biol Chem 273 (26): 15971-9. PMID 9632645.  
  2. ^ Verhaagh S, Schweifer N, Barlow DP, Zwart R (Sep 1999). "Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27". Genomics 55 (2): 209-18. doi:10.1006/geno.1998.5639. PMID 9933568.  
  3. ^ a b "Entrez Gene: SLC22A3 solute carrier family 22 (extraneuronal monoamine transporter), member 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6581.  

Further reading

  • Wu X, Kekuda R, Huang W, et al. (1999). "Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain.". J. Biol. Chem. 273 (49): 32776–86. doi:10.1074/jbc.273.49.32776. PMID 9830022.  
  • Gründemann D, Schechinger B, Rappold GA, Schömig E (1999). "Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter.". Nat. Neurosci. 1 (5): 349–51. doi:10.1038/1557. PMID 10196521.  
  • Gründemann D, Schömig E (2000). "Gene structures of the human non-neuronal monoamine transporters EMT and OCT2.". Hum. Genet. 106 (6): 627–35. doi:10.1007/s004390050035. PMID 10942111.  
  • Wu X, Huang W, Ganapathy ME, et al. (2000). "Structure, function, and regional distribution of the organic cation transporter OCT3 in the kidney.". Am. J. Physiol. Renal Physiol. 279 (3): F449–58. PMID 10966924.  
  • Wieland A, Hayer-Zillgen M, Bönisch H, Brüss M (2001). "Analysis of the gene structure of the human (SLC22A3) and murine (Slc22a3) extraneuronal monoamine transporter.". Journal of neural transmission (Vienna, Austria : 1996) 107 (10): 1149–57. doi:10.1007/s007020070028. PMID 11129104.  
  • Wessler I, Roth E, Deutsch C, et al. (2001). "Release of non-neuronal acetylcholine from the isolated human placenta is mediated by organic cation transporters.". Br. J. Pharmacol. 134 (5): 951–6. doi:10.1038/sj.bjp.0704335. PMID 11682442.  
  • Martel F, Keating E, Calhau C, et al. (2002). "Regulation of human extraneuronal monoamine transporter (hEMT) expressed in HEK293 cells by intracellular second messenger systems.". Naunyn Schmiedebergs Arch. Pharmacol. 364 (6): 487–95. doi:10.1007/s002100100476. PMID 11770002.  
  • Hayer-Zillgen M, Brüss M, Bönisch H (2003). "Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3.". Br. J. Pharmacol. 136 (6): 829–36. doi:10.1038/sj.bjp.0704785. PMID 12110607.  
  • Gründemann D, Hahne C, Berkels R, Schömig E (2003). "Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2).". J. Pharmacol. Exp. Ther. 304 (2): 810–7. doi:10.1124/jpet.102.044404. PMID 12538837.  
  • Lazar A, Gründemann D, Berkels R, et al. (2003). "Genetic variability of the extraneuronal monoamine transporter EMT (SLC22A3).". J. Hum. Genet. 48 (5): 226–30. doi:10.1007/s10038-003-0015-5. PMID 12768439.  
  • Haag C, Berkels R, Gründemann D, et al. (2004). "The localisation of the extraneuronal monoamine transporter (EMT) in rat brain.". J. Neurochem. 88 (2): 291–7. PMID 14690517.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Bottalico B, Larsson I, Brodszki J, et al. (2004). "Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies.". Placenta 25 (6): 518–29. doi:10.1016/j.placenta.2003.10.017. PMID 15135235.  
  • Jiang W, Prokopenko O, Wong L, et al. (2005). "IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity.". Mol. Cell. Biol. 25 (15): 6496–508. doi:10.1128/MCB.25.15.6496-6508.2005. PMID 16024787.  
  • Bourdet DL, Pritchard JB, Thakker DR (2006). "Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3).". J. Pharmacol. Exp. Ther. 315 (3): 1288–97. doi:10.1124/jpet.105.091223. PMID 16141367.  
  • Aoyama N, Takahashi N, Kitaichi K, et al. (2006). "Association between gene polymorphisms of SLC22A3 and methamphetamine use disorder.". Alcohol. Clin. Exp. Res. 30 (10): 1644–9. doi:10.1111/j.1530-0277.2006.00215.x. PMID 17010131.  
  • Bottalico B, Noskova V, Pilka R, et al. (2007). "The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show differential distribution and cyclic expression pattern in human endometrium and early pregnancy decidua.". Mol. Reprod. Dev. 74 (10): 1303–11. doi:10.1002/mrd.20697. PMID 17393420.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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