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SLC22A7: Wikis

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Solute carrier family 22 (organic anion transporter), member 7
Identifiers
Symbols SLC22A7; MGC24091; MGC45202; NLT; OAT2
External IDs OMIM604995 MGI1859559 HomoloGene21328 GeneCards: SLC22A7 Gene
RNA expression pattern
PBB GE SLC22A7 220554 at tn.png
PBB GE SLC22A7 221661 at tn.png
PBB GE SLC22A7 221662 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 10864 108114
Ensembl ENSG00000137204 ENSMUSG00000067144
UniProt n/a n/a
RefSeq (mRNA) NM_006672 XM_001002761
RefSeq (protein) NP_006663 XP_001002761
Location (UCSC) Chr 6:
43.37 - 43.38 Mb
Chr 17:
45.9 - 45.9 Mb
PubMed search [1] [2]

Solute carrier family 22 member 7 is a protein that in humans is encoded by the SLC22A7 gene.[1][2][3]

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described.[3]

See also

References

  1. ^ Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H (Jul 1998). "Identification of multispecific organic anion transporter 2 expressed predominantly in the liver". FEBS Lett 429 (2): 179–82. PMID 9650585.  
  2. ^ Kok LD, Siu SS, Fung KP, Tsui SK, Lee CY, Waye MM (Jun 2000). "Assignment of liver-specific organic anion transporter (SLC22A7) to human chromosome 6 bands p21.2→p21.1 using radiation hybrids". Cytogenet Cell Genet 88 (1-2): 76–7. PMID 10773670.  
  3. ^ a b "Entrez Gene: SLC22A7 solute carrier family 22 (organic anion transporter), member 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10864.  

Further reading

  • Cropp CD, Komori T, Shima JE, et al. (2008). "Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP.". Mol. Pharmacol. 73 (4): 1151–8. doi:10.1124/mol.107.043117. PMID 18216183.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Enomoto A, Takeda M, Shimoda M, et al. (2002). "Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors.". J. Pharmacol. Exp. Ther. 301 (3): 797–802. doi:10.1124/jpet.301.3.797. PMID 12023506.  
  • Kimura H, Takeda M, Narikawa S, et al. (2002). "Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins.". J. Pharmacol. Exp. Ther. 301 (1): 293–8. doi:10.1124/jpet.301.1.293. PMID 11907186.  
  • Babu E, Takeda M, Narikawa S, et al. (2002). "Human organic anion transporters mediate the transport of tetracycline.". Jpn. J. Pharmacol. 88 (1): 69–76. doi:10.1254/jjp.88.69. PMID 11855680.  
  • Sun W, Wu RR, van Poelje PD, Erion MD (2001). "Isolation of a family of organic anion transporters from human liver and kidney.". Biochem. Biophys. Res. Commun. 283 (2): 417–22. doi:10.1006/bbrc.2001.4774. PMID 11327718.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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