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Solute carrier family 23 (nucleobase transporters), member 1
Symbols SLC23A1; SLC23A2; MGC22361; SVCT1; YSPL3
External IDs OMIM603790 MGI1341903 HomoloGene40769 GeneCards: SLC23A1 Gene
Species Human Mouse
Entrez 9963 20522
Ensembl ENSG00000170482 ENSMUSG00000024354
UniProt Q9UHI7 Q9Z2J0
RefSeq (mRNA) NM_005847 NM_011397
RefSeq (protein) NP_005838 NP_035527
Location (UCSC) Chr 5:
138.73 - 138.75 Mb
Chr 18:
35.74 - 35.75 Mb
PubMed search [1] [2]

Solute carrier family 23 member 1 is a protein that in humans is encoded by the SLC23A1 gene.[1][2][3]

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2.[3]

See also


  1. ^ Faaland CA, Race JE, Ricken G, Warner FJ, Williams WJ, Holtzman EJ (Dec 1998). "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters". Biochim Biophys Acta 1442 (2-3): 353-60. PMID 9804989.  
  2. ^ Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA (Jun 1999). "A family of mammalian Na+-dependent L-ascorbic acid transporters". Nature 399 (6731): 70-5. doi:10.1038/19986. PMID 10331392.  
  3. ^ a b "Entrez Gene: SLC23A1 solute carrier family 23 (nucleobase transporters), member 1".  

Further reading

  • Liang WJ, Johnson D, Jarvis SM (2001). "Vitamin C transport systems of mammalian cells.". Mol. Membr. Biol. 18 (1): 87–95. doi:10.1080/09687680110033774. PMID 11396616.  
  • Hogue DL, Ling V (1999). "A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals.". Genomics 59 (1): 18–23. doi:10.1006/geno.1999.5847. PMID 10395795.  
  • Rajan DP, Huang W, Dutta B, et al. (1999). "Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function.". Biochem. Biophys. Res. Commun. 262 (3): 762–8. doi:10.1006/bbrc.1999.1272. PMID 10471399.  
  • Wang H, Dutta B, Huang W, et al. (1999). "Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant.". Biochim. Biophys. Acta 1461 (1): 1–9. doi:10.1016/S0005-2736(99)00182-0. PMID 10556483.  
  • Daruwala R, Song J, Koh WS, et al. (1999). "Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2.". FEBS Lett. 460 (3): 480–4. doi:10.1016/S0014-5793(99)01393-9. PMID 10556521.  
  • Wang Y, Mackenzie B, Tsukaguchi H, et al. (2000). "Human vitamin C (L-ascorbic acid) transporter SVCT1.". Biochem. Biophys. Res. Commun. 267 (2): 488–94. doi:10.1006/bbrc.1999.1929. PMID 10631088.  
  • Erichsen HC, Eck P, Levine M, Chanock S (2001). "Characterization of the genomic structure of the human vitamin C transporter SVCT1 (SLC23A2).". J. Nutr. 131 (10): 2623–7. PMID 11584081.  
  • Hediger MA (2002). "New view at C.". Nat. Med. 8 (5): 445–6. doi:10.1038/nm0502-445. PMID 11984580.  
  • Maulén NP, Henríquez EA, Kempe S, et al. (2003). "Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells.". J. Biol. Chem. 278 (11): 9035–41. doi:10.1074/jbc.M205119200. PMID 12381735.  
  • Liang WJ, Johnson D, Ma LS, et al. (2002). "Regulation of the human vitamin C transporters expressed in COS-1 cells by protein kinase C [corrected].". Am. J. Physiol., Cell Physiol. 283 (6): C1696–704. doi:10.1152/ajpcell.00461.2001. PMID 12388072.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Subramanian VS, Marchant JS, Boulware MJ, Said HM (2004). "A C-terminal region dictates the apical plasma membrane targeting of the human sodium-dependent vitamin C transporter-1 in polarized epithelia.". J. Biol. Chem. 279 (26): 27719–28. doi:10.1074/jbc.M400876200. PMID 15084584.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Boyer JC, Campbell CE, Sigurdson WJ, Kuo SM (2005). "Polarized localization of vitamin C transporters, SVCT1 and SVCT2, in epithelial cells.". Biochem. Biophys. Res. Commun. 334 (1): 150–6. doi:10.1016/j.bbrc.2005.06.069. PMID 15993839.  
  • Erichsen HC, Engel SA, Eck PK, et al. (2006). "Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery.". Am. J. Epidemiol. 163 (3): 245–54. doi:10.1093/aje/kwj035. PMID 16357110.  
  • Kang JS, Kim HN, Jung da J, et al. (2007). "Regulation of UVB-induced IL-8 and MCP-1 production in skin keratinocytes by increasing vitamin C uptake via the redistribution of SVCT-1 from the cytosol to the membrane.". J. Invest. Dermatol. 127 (3): 698–706. doi:10.1038/sj.jid.5700572. PMID 17008880.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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