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Solute carrier family 23 (nucleobase transporters), member 2
Identifiers
Symbols SLC23A2; KIAA0238; NBTL1; SLC23A1; SVCT2; YSPL2
External IDs OMIM603791 MGI1859682 HomoloGene68440 GeneCards: SLC23A2 Gene
RNA expression pattern
PBB GE SLC23A2 209236 at tn.png
PBB GE SLC23A2 209237 s at tn.png
PBB GE SLC23A2 211572 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9962 54338
Ensembl ENSG00000089057 ENSMUSG00000027340
UniProt Q9UGH3 Q3TDU7
RefSeq (mRNA) NM_005116 NM_018824
RefSeq (protein) NP_005107 NP_061294
Location (UCSC) Chr 20:
4.78 - 4.94 Mb
Chr 2:
131.74 - 131.84 Mb
PubMed search [1] [2]

Solute carrier family 23 member 2 is a protein that in humans is encoded by the SLC23A2 gene.[1][2][3]

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1.[3]

See also

References

  1. ^ Faaland CA, Race JE, Ricken G, Warner FJ, Williams WJ, Holtzman EJ (Dec 1998). "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters". Biochim Biophys Acta 1442 (2-3): 353-60. PMID 9804989.  
  2. ^ Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA (Jun 1999). "A family of mammalian Na+-dependent L-ascorbic acid transporters". Nature 399 (6731): 70-5. doi:10.1038/19986. PMID 10331392.  
  3. ^ a b "Entrez Gene: SLC23A2 solute carrier family 23 (nucleobase transporters), member 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9962.  

Further reading

  • Liang WJ, Johnson D, Jarvis SM (2001). "Vitamin C transport systems of mammalian cells.". Mol. Membr. Biol. 18 (1): 87–95. doi:10.1080/09687680110033774. PMID 11396616.  
  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.  
  • Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.  
  • Hogue DL, Ling V (1999). "A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals.". Genomics 59 (1): 18–23. doi:10.1006/geno.1999.5847. PMID 10395795.  
  • Rajan DP, Huang W, Dutta B, et al. (1999). "Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function.". Biochem. Biophys. Res. Commun. 262 (3): 762–8. doi:10.1006/bbrc.1999.1272. PMID 10471399.  
  • Daruwala R, Song J, Koh WS, et al. (1999). "Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2.". FEBS Lett. 460 (3): 480–4. doi:10.1016/S0014-5793(99)01393-9. PMID 10556521.  
  • Breton S, Wiederhold T, Marshansky V, et al. (2000). "The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells.". J. Biol. Chem. 275 (24): 18219–24. doi:10.1074/jbc.M909857199. PMID 10748165.  
  • Holliday LS, Lu M, Lee BS, et al. (2000). "The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site.". J. Biol. Chem. 275 (41): 32331–7. doi:10.1074/jbc.M004795200. PMID 10915794.  
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.  
  • Hediger MA (2002). "New view at C.". Nat. Med. 8 (5): 445–6. doi:10.1038/nm0502-445. PMID 11984580.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Fischer H, Schwarzer C, Illek B (2004). "Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel.". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3691–6. doi:10.1073/pnas.0308393100. PMID 14993613.  
  • Lutsenko EA, Carcamo JM, Golde DW (2004). "A human sodium-dependent vitamin C transporter 2 isoform acts as a dominant-negative inhibitor of ascorbic acid transport.". Mol. Cell. Biol. 24 (8): 3150–6. doi:10.1128/MCB.24.8.3150-3156.2004. PMID 15060139.  
  • Seno T, Inoue N, Matsui K, et al. (2004). "Functional expression of sodium-dependent vitamin C transporter 2 in human endothelial cells.". J. Vasc. Res. 41 (4): 345–51. doi:10.1159/000080525. PMID 15340249.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • McNulty AL, Vail TP, Kraus VB (2005). "Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2.". Biochim. Biophys. Acta 1712 (2): 212–21. doi:10.1016/j.bbamem.2005.04.009. PMID 15921655.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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