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SLC25A10: Wikis


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Solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
Symbols SLC25A10; DIC
External IDs OMIM606794 MGI1353497 HomoloGene6519 GeneCards: SLC25A10 Gene
RNA expression pattern
PBB GE SLC25A10 218275 at tn.png
More reference expression data
Species Human Mouse
Entrez 1468 27376
Ensembl ENSG00000183048 ENSMUSG00000025792
UniProt Q9UBX3 Q9QZD8
RefSeq (mRNA) NM_012140 NM_013770
RefSeq (protein) NP_036272 NP_038798
Location (UCSC) Chr 17:
77.29 - 77.3 Mb
Chr 11:
120.31 - 120.32 Mb
PubMed search [1] [2]

Mitochondrial dicarboxylate carrier is a protein that in humans is encoded by the SLC25A10 gene.[1][2][3]

The dicarboxylate carrier catalyzes the transport of dicarboxylates such as malate and succinate across the mitochondrial membrane in exchange for phosphate, sulfate, and thiosulfate, thus supplying substrates for the Krebs cycle, gluconeogenesis, urea synthesis, and sulfur metabolism.[supplied by OMIM][3]

See also


  1. ^ Fiermonte G, Palmieri L, Dolce V, Lasorsa FM, Palmieri F, Runswick MJ, Walker JE (Oct 1998). "The sequence, bacterial expression, and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans". J Biol Chem 273 (38): 24754-9. PMID 9733776.  
  2. ^ Pannone E, Fiermonte G, Dolce V, Rocchi M, Palmieri F (Mar 1999). "Assignment of the human dicarboxylate carrier gene (DIC) to chromosome 17 band 17q25.3". Cytogenet Cell Genet 83 (3-4): 238-9. PMID 10072589.  
  3. ^ a b "Entrez Gene: SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10".  

Further reading

  • Fiermonte G, Dolce V, Arrigoni R, et al. (2000). "Organization and sequence of the gene for the human mitochondrial dicarboxylate carrier: evolution of the carrier family.". Biochem. J. 344 Pt 3: 953–60. PMID 10585886.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Douglas MW, Diefenbach RJ, Homa FL, et al. (2004). "Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport.". J. Biol. Chem. 279 (27): 28522–30. doi:10.1074/jbc.M311671200. PMID 15117959.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Mizuarai S, Miki S, Araki H, et al. (2005). "Identification of dicarboxylate carrier Slc25a10 as malate transporter in de novo fatty acid synthesis.". J. Biol. Chem. 280 (37): 32434–41. doi:10.1074/jbc.M503152200. PMID 16027120.  
  • Khanna H, Hurd TW, Lillo C, et al. (2005). "RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins.". J. Biol. Chem. 280 (39): 33580–7. doi:10.1074/jbc.M505827200. PMID 16043481.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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