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SLC25A14: Wikis


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Solute carrier family 25 (mitochondrial carrier, brain), member 14
Symbols SLC25A14; BMCP1; MGC149543; UCP5
External IDs OMIM300242 MGI1330823 HomoloGene2937 GeneCards: SLC25A14 Gene
RNA expression pattern
PBB GE SLC25A14 204587 at tn.png
PBB GE SLC25A14 211855 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9016 20523
Ensembl ENSG00000102078 ENSMUSG00000031105
UniProt O95258 Q8CJ23
RefSeq (mRNA) NM_003951 NM_011398
RefSeq (protein) NP_003942 NP_035528
Location (UCSC) Chr X:
129.3 - 129.34 Mb
Chr X:
44.87 - 44.91 Mb
PubMed search [1] [2]

Brain mitochondrial carrier protein 1 is a protein that in humans is encoded by the SLC25A14 gene.[1][2]

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is widely expressed in many tissues with the greatest abundance in brain and testis. The gene product has an N-terminal hydrophobic domain that is not present in other UCPs. Two splice variants have been found for this gene.[2]

See also


  1. ^ Sanchis D, Fleury C, Chomiki N, Goubern M, Huang Q, Neverova M, Gregoire F, Easlick J, Raimbault S, Levi-Meyrueis C, Miroux B, Collins S, Seldin M, Richard D, Warden C, Bouillaud F, Ricquier D (Jan 1999). "BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast". J Biol Chem 273 (51): 34611-5. PMID 9852133.  
  2. ^ a b "Entrez Gene: SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14".  

Further reading

  • Ricquier D, Bouillaud F (2000). "The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP.". Biochem. J. 345 Pt 2: 161–79. doi:10.1042/0264-6021:3450161. PMID 10620491.  
  • Jezek P, Urbánková E (2000). "Specific sequence of motifs of mitochondrial uncoupling proteins.". IUBMB Life 49 (1): 63–70. PMID 10772343.  
  • Yu XX, Mao W, Zhong A, et al. (2000). "Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation.". Faseb J. 14 (11): 1611–8. doi:10.1096/fj.14.11.1611. PMID 10928996.  
  • Kim-Han JS, Reichert SA, Quick KL, Dugan LL (2001). "BMCP1: a mitochondrial uncoupling protein in neurons which regulates mitochondrial function and oxidant production.". J. Neurochem. 79 (3): 658–68. doi:10.1046/j.1471-4159.2001.00604.x. PMID 11701769.  
  • Yang X, Pratley RE, Tokraks S, et al. (2002). "UCP5/BMCP1 transcript isoforms in human skeletal muscle: relationship of the short-insert isoform with lipid oxidation and resting metabolic rates.". Mol. Genet. Metab. 75 (4): 369–73. doi:10.1016/S1096-7192(02)00008-2. PMID 12051969.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.  
  • Ho PW, Chu AC, Kwok KH, et al. (2007). "Knockdown of uncoupling protein-5 in neuronal SH-SY5Y cells: Effects on MPP+-induced mitochondrial membrane depolarization, ATP deficiency, and oxidative cytotoxicity.". J. Neurosci. Res. 84 (6): 1358–66. doi:10.1002/jnr.21034. PMID 16941493.  
  • Yasuno K, Ando S, Misumi S, et al. (2007). "Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (2): 250–3. doi:10.1002/ajmg.b.30443. PMID 17066476.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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