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SLC25A27: Wikis


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Solute carrier family 25, member 27
Symbols SLC25A27; FLJ33552; UCP4
External IDs MGI1921261 HomoloGene12523 GeneCards: SLC25A27 Gene
Species Human Mouse
Entrez 9481 74011
Ensembl ENSG00000153291 ENSMUSG00000023912
UniProt O95847 n/a
RefSeq (mRNA) NM_004277 NM_028711
RefSeq (protein) NP_004268 NP_082987
Location (UCSC) Chr 6:
46.73 - 46.76 Mb
Chr 17:
43.1 - 43.13 Mb
PubMed search [1] [2]

Mitochondrial uncoupling protein 4 is a protein that in humans is encoded by the SLC25A27 gene.[1][2][3]

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental conditions.[3]

See also


  1. ^ Mao W, Yu XX, Zhong A, Li W, Brush J, Sherwood SW, Adams SH, Pan G (Mar 1999). "UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells". FEBS Lett 443 (3): 326-30. PMID 10025957.  
  2. ^ Jezek P, Urbankova E (Jun 2000). "Specific sequence of motifs of mitochondrial uncoupling proteins". IUBMB Life 49 (1): 63-70. doi:10.1080/713803586. PMID 10772343.  
  3. ^ a b "Entrez Gene: SLC25A27 solute carrier family 25, member 27".  

Further reading

  • Ricquier D, Bouillaud F (2000). "The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP.". Biochem. J. 345 Pt 2: 161–79. doi:10.1042/0264-6021:3450161. PMID 10620491.  
  • Muzzin P (2002). "The uncoupling proteins.". Ann. Endocrinol. (Paris) 63 (2 Pt 1): 106–10. PMID 11994670.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Yu XX, Mao W, Zhong A, et al. (2000). "Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation.". Faseb J. 14 (11): 1611–8. doi:10.1096/fj.14.11.1611. PMID 10928996.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Liu D, Chan SL, de Souza-Pinto NC, et al. (2007). "Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress.". Neuromolecular Med. 8 (3): 389–414. doi:10.1385/NMM:8:3:389. PMID 16775390.  
  • Chan SL, Liu D, Kyriazis GA, et al. (2007). "Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells.". J. Biol. Chem. 281 (49): 37391–403. doi:10.1074/jbc.M605552200. PMID 17035241.  
  • Yasuno K, Ando S, Misumi S, et al. (2007). "Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (2): 250–3. doi:10.1002/ajmg.b.30443. PMID 17066476.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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