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SLC25A3: Wikis


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Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
Symbols SLC25A3; OK/SW-cl.48; PHC
External IDs OMIM600370 MGI1353498 HomoloGene37649 GeneCards: SLC25A3 Gene
Species Human Mouse
Entrez 5250 18674
Ensembl ENSG00000075415 ENSMUSG00000061904
UniProt Q00325 Q3THU8
RefSeq (mRNA) NM_213612 NM_133668
RefSeq (protein) NP_998777 NP_598429
Location (UCSC) Chr 12:
97.51 - 97.52 Mb
Chr 10:
90.55 - 90.55 Mb
PubMed search [1] [2]

Phosphate carrier protein, mitochondrial is a protein that in humans is encoded by the SLC25A3 gene.[1][2]

The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated.[2]

See also


  1. ^ Jabs EW, Thomas PJ, Bernstein M, Coss C, Ferreira GC, Pedersen PL (Jun 1994). "Chromosomal localization of genes required for the terminal steps of oxidative metabolism: alpha and gamma subunits of ATP synthase and the phosphate carrier". Hum Genet 93 (5): 600-2. PMID 8168843.  
  2. ^ a b "Entrez Gene: SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3".  

Further reading

  • Dolce V, Fiermonte G, Messina A, Palmieri F (1992). "Nucleotide sequence of a human heart cDNA encoding the mitochondrial phosphate carrier.". DNA Seq. 2 (2): 133–5. doi:10.3109/10425179109039683. PMID 1777677.  
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Dolce V, Iacobazzi V, Palmieri F, Walker JE (1994). "The sequences of human and bovine genes of the phosphate carrier from mitochondria contain evidence of alternatively spliced forms.". J. Biol. Chem. 269 (14): 10451–60. PMID 8144629.  
  • Marsh S, Carter NP, Dolce V, et al. (1996). "Chromosomal localization of the mitochondrial phosphate carrier gene PHC to 12q23.". Genomics 29 (3): 814–5. doi:10.1006/geno.1995.9924. PMID 8575787.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Huizing M, Ruitenbeek W, van den Heuvel LP, et al. (1999). "Human mitochondrial transmembrane metabolite carriers: tissue distribution and its implication for mitochondrial disorders.". J. Bioenerg. Biomembr. 30 (3): 277–84. doi:10.1023/A:1020501021222. PMID 9733094.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.  
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Iacobazzi V, Infantino V, Costanzo P, et al. (2006). "Functional analysis of the promoter of the mitochondrial phosphate carrier human gene: identification of activator and repressor elements and their transcription factors.". Biochem. J. 391 (Pt 3): 613–21. doi:10.1042/BJ20050776. PMID 15984930.  
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.  
  • Mayr JA, Merkel O, Kohlwein SD, et al. (2007). "Mitochondrial phosphate-carrier deficiency: a novel disorder of oxidative phosphorylation.". Am. J. Hum. Genet. 80 (3): 478–84. doi:10.1086/511788. PMID 17273968.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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