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Solute carrier family 26, member 8
Identifiers
Symbols SLC26A8; FLJ32714; TAT1
External IDs OMIM608480 MGI2385046 HomoloGene27095 GeneCards: SLC26A8 Gene
Orthologs
Species Human Mouse
Entrez 116369 224661
Ensembl ENSG00000112053 ENSMUSG00000036196
UniProt n/a n/a
RefSeq (mRNA) NM_052961 NM_146076
RefSeq (protein) NP_443193 NP_666188
Location (UCSC) Chr 6:
36.02 - 36.1 Mb
Chr 17:
28.37 - 28.42 Mb
PubMed search [1] [2]

Testis anion transporter 1 is a protein that in humans is encoded by the SLC26A8 gene.[1][2][3]

This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. This gene is expressed primarily in spermatocytes. Two transcript variants encoding different isoforms have been found.[3]

Interactions

SLC26A8 has been shown to interact with RACGAP1.[4]

References

  1. ^ Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J (Apr 2002). "Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9". J Biol Chem 277 (16): 14246–54. doi:10.1074/jbc.M111802200. PMID 11834742.  
  2. ^ Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP (Feb 2002). "Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney". Genomics 79 (2): 249–56. doi:10.1006/geno.2002.6689. PMID 11829495.  
  3. ^ a b "Entrez Gene: SLC26A8 solute carrier family 26, member 8". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116369.  
  4. ^ Toure, A; Morin L, Pineau C, Becq F, Dorseuil O, Gacon G (Jun. 2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling". J. Biol. Chem. (United States) 276 (23): 20309–15. doi:10.1074/jbc.M011740200. ISSN 0021-9258. PMID 11278976.  

Further reading

  • Markovich D (2001). "Physiological roles and regulation of mammalian sulfate transporters.". Physiol. Rev. 81 (4): 1499–533. PMID 11581495.  
  • Mäkelä S, Eklund R, Lähdetie J, et al. (2005). "Mutational analysis of the human SLC26A8 gene: exclusion as a candidate for male infertility due to primary spermatogenic failure.". Mol. Hum. Reprod. 11 (2): 129–32. doi:10.1093/molehr/gah140. PMID 15579655.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Toure A, Morin L, Pineau C, et al. (2001). "Tat1, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to rhogtpase signaling.". J. Biol. Chem. 276 (23): 20309–15. doi:10.1074/jbc.M011740200. PMID 11278976.  
  • Mocellin R, Bühlmeyer K (1976). "Late banding operation in children with ventricular septal defect and pulmonary arterial hypertension.". European journal of cardiology 3 (3): 205–11. PMID 1183472.  
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