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Solute carrier family 29 (nucleoside transporters), member 1
Identifiers
Symbols SLC29A1; ENT1; MGC1465; MGC3778
External IDs OMIM602193 MGI1927073 HomoloGene37985 GeneCards: SLC29A1 Gene
RNA expression pattern
PBB GE SLC29A1 201801 s at tn.png
PBB GE SLC29A1 201802 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2030 63959
Ensembl ENSG00000112759 ENSMUSG00000023942
UniProt Q99808 Q3UJY1
RefSeq (mRNA) NM_001078174 NM_022880
RefSeq (protein) NP_001071642 NP_075018
Location (UCSC) Chr 6:
44.3 - 44.31 Mb
Chr 17:
45.05 - 45.06 Mb
PubMed search [1] [2]

Equilibrative nucleoside transporter 1 (ENT1) is a protein that in humans is encoded by the SLC29A1 gene.[1][2]

This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.[3]

See also

References

  1. ^ Griffiths M, Beaumont N, Yao SY, Sundaram M, Boumah CE, Davies A, Kwong FY, Coe I, Cass CE, Young JD, Baldwin SA (Jan 1997). "Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs". Nat Med 3 (1): 89-93. PMID 8986748.  
  2. ^ Coe IR, Griffiths M, Young JD, Baldwin SA, Cass CE (Feb 1998). "Assignment of the human equilibrative nucleoside transporter (hENT1) to 6p21.1-p21.2". Genomics 45 (2): 459-60. doi:10.1006/geno.1997.4928. PMID 9344680.  
  3. ^ "Entrez Gene: SLC29A1 solute carrier family 29 (nucleoside transporters), member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2030.  

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Griffiths M, Yao SY, Abidi F, et al. (1998). "Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta.". Biochem. J. 328 ( Pt 3): 739–43. PMID 9396714.  
  • Lum PY, Ngo LY, Bakken AH, Unadkat JD (2000). "Human intestinal es nucleoside transporter: molecular characterization and nucleoside inhibitory profiles.". Cancer Chemother. Pharmacol. 45 (4): 273–8. doi:10.1007/s002800050040. PMID 10755314.  
  • Sundaram M, Yao SY, Ingram JC, et al. (2002). "Topology of a human equilibrative, nitrobenzylthioinosine (NBMPR)-sensitive nucleoside transporter (hENT1) implicated in the cellular uptake of adenosine and anti-cancer drugs.". J. Biol. Chem. 276 (48): 45270–5. doi:10.1074/jbc.M107169200. PMID 11584005.  
  • SenGupta DJ, Lum PY, Lai Y, et al. (2002). "A single glycine mutation in the equilibrative nucleoside transporter gene, hENT1, alters nucleoside transport activity and sensitivity to nitrobenzylthioinosine.". Biochemistry 41 (5): 1512–9. doi:10.1021/bi015833w. PMID 11814344.  
  • Yao SY, Ng AM, Vickers MF, et al. (2002). "Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation.". J. Biol. Chem. 277 (28): 24938–48. doi:10.1074/jbc.M200966200. PMID 12006583.  
  • Galmarini CM, Thomas X, Calvo F, et al. (2002). "Potential mechanisms of resistance to cytarabine in AML patients.". Leuk. Res. 26 (7): 621–9. doi:10.1016/S0145-2126(01)00184-9. PMID 12008078.  
  • Lai Y, Bakken AH, Unadkat JD (2002). "Simultaneous expression of hCNT1-CFP and hENT1-YFP in Madin-Darby canine kidney cells. Localization and vectorial transport studies.". J. Biol. Chem. 277 (40): 37711–7. doi:10.1074/jbc.M204986200. PMID 12097333.  
  • Sankar N, Machado J, Abdulla P, et al. (2002). "Comparative genomic analysis of equilibrative nucleoside transporters suggests conserved protein structure despite limited sequence identity.". Nucleic Acids Res. 30 (20): 4339–50. doi:10.1093/nar/gkf564. PMID 12384580.  
  • Reiman T, Clarke ML, Dabbagh L, et al. (2003). "Differential expression of human equilibrative nucleoside transporter 1 (hENT1) protein in the Reed-Sternberg cells of Hodgkin's disease.". Leuk. Lymphoma 43 (7): 1435–40. PMID 12389626.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Mangravite LM, Xiao G, Giacomini KM (2003). "Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells.". Am. J. Physiol. Renal Physiol. 284 (5): F902–10. doi:10.1152/ajprenal.00215.2002. PMID 12527552.  
  • Szkotak AJ, Ng AM, Man SF, et al. (2003). "Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells.". J. Membr. Biol. 192 (3): 169–79. doi:10.1007/s00232-002-1073-x. PMID 12820662.  
  • Lai Y, Tse CM, Unadkat JD (2004). "Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs.". J. Biol. Chem. 279 (6): 4490–7. doi:10.1074/jbc.M307938200. PMID 14607828.  
  • Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Endres CJ, Sengupta DJ, Unadkat JD (2004). "Mutation of leucine-92 selectively reduces the apparent affinity of inosine, guanosine, NBMPR [S6-(4-nitrobenzyl)-mercaptopurine riboside] and dilazep for the human equilibrative nucleoside transporter, hENT1.". Biochem. J. 380 (Pt 1): 131–7. doi:10.1042/BJ20031880. PMID 14759222.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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edit
Solute carrier family 29 (nucleoside transporters), member 1
Identifiers
Symbols SLC29A1; ENT1; MGC1465; MGC3778
External IDs OMIM: 602193 MGI1927073 HomoloGene37985
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 2030 63959
Ensembl ENSG00000112759 ENSMUSG00000023942
Uniprot Q99808 Q3UJY1
Refseq NM_001078174 (mRNA)
NP_001071642 (protein)
NM_022880 (mRNA)
NP_075018 (protein)
Location Chr 6: 44.3 - 44.31 Mb Chr 17: 45.05 - 45.06 Mb
Pubmed search [1] [2]

Solute carrier family 29 (nucleoside transporters), member 1, also known as SLC29A1, is a human gene.

This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.[1]

See also

References

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
  • Griffiths M, Beaumont N, Yao SY, et al. (1997). "Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs.". Nat. Med. 3 (1): 89–93. doi:10.1038/nm0197-89. PMID 8986748. 
  • Coe IR, Griffiths M, Young JD, et al. (1998). "Assignment of the human equilibrative nucleoside transporter (hENT1) to 6p21.1-p21.2.". Genomics 45 (2): 459–60. doi:10.1006/geno.1997.4928. PMID 9344680. 
  • Griffiths M, Yao SY, Abidi F, et al. (1998). "Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta.". Biochem. J. 328 ( Pt 3): 739–43. PMID 9396714. 
  • Lum PY, Ngo LY, Bakken AH, Unadkat JD (2000). "Human intestinal es nucleoside transporter: molecular characterization and nucleoside inhibitory profiles.". Cancer Chemother. Pharmacol. 45 (4): 273–8. doi:10.1007/s002800050040. PMID 10755314. 
  • Sundaram M, Yao SY, Ingram JC, et al. (2002). "Topology of a human equilibrative, nitrobenzylthioinosine (NBMPR)-sensitive nucleoside transporter (hENT1) implicated in the cellular uptake of adenosine and anti-cancer drugs.". J. Biol. Chem. 276 (48): 45270–5. doi:10.1074/jbc.M107169200. PMID 11584005. 
  • SenGupta DJ, Lum PY, Lai Y, et al. (2002). "A single glycine mutation in the equilibrative nucleoside transporter gene, hENT1, alters nucleoside transport activity and sensitivity to nitrobenzylthioinosine.". Biochemistry 41 (5): 1512–9. doi:10.1021/bi015833w. PMID 11814344. 
  • Yao SY, Ng AM, Vickers MF, et al. (2002). "Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation.". J. Biol. Chem. 277 (28): 24938–48. doi:10.1074/jbc.M200966200. PMID 12006583. 
  • Galmarini CM, Thomas X, Calvo F, et al. (2002). "Potential mechanisms of resistance to cytarabine in AML patients.". Leuk. Res. 26 (7): 621–9. doi:10.1016/S0145-2126(01)00184-9. PMID 12008078. 
  • Lai Y, Bakken AH, Unadkat JD (2002). "Simultaneous expression of hCNT1-CFP and hENT1-YFP in Madin-Darby canine kidney cells. Localization and vectorial transport studies.". J. Biol. Chem. 277 (40): 37711–7. doi:10.1074/jbc.M204986200. PMID 12097333. 
  • Sankar N, Machado J, Abdulla P, et al. (2002). "Comparative genomic analysis of equilibrative nucleoside transporters suggests conserved protein structure despite limited sequence identity.". Nucleic Acids Res. 30 (20): 4339–50. doi:10.1093/nar/gkf564. PMID 12384580. 
  • Reiman T, Clarke ML, Dabbagh L, et al. (2003). "Differential expression of human equilibrative nucleoside transporter 1 (hENT1) protein in the Reed-Sternberg cells of Hodgkin's disease.". Leuk. Lymphoma 43 (7): 1435–40. PMID 12389626. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Mangravite LM, Xiao G, Giacomini KM (2003). "Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells.". Am. J. Physiol. Renal Physiol. 284 (5): F902–10. doi:10.1152/ajprenal.00215.2002. PMID 12527552. 
  • Szkotak AJ, Ng AM, Man SF, et al. (2003). "Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells.". J. Membr. Biol. 192 (3): 169–79. doi:10.1007/s00232-002-1073-x. PMID 12820662. 
  • Lai Y, Tse CM, Unadkat JD (2004). "Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs.". J. Biol. Chem. 279 (6): 4490–7. doi:10.1074/jbc.M307938200. PMID 14607828. 
  • Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Endres CJ, Sengupta DJ, Unadkat JD (2004). "Mutation of leucine-92 selectively reduces the apparent affinity of inosine, guanosine, NBMPR [S6-(4-nitrobenzyl)-mercaptopurine riboside] and dilazep for the human equilibrative nucleoside transporter, hENT1.". Biochem. J. 380 (Pt 1): 131–7. doi:10.1042/BJ20031880. PMID 14759222. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 


This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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