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Solute carrier family 29 (nucleoside transporters), member 4
Symbols SLC29A4; ENT4; FLJ34923; PMAT
External IDs OMIM609149 MGI2385330 HomoloGene71345 GeneCards: SLC29A4 Gene
Species Human Mouse
Entrez 222962 243328
Ensembl n/a ENSMUSG00000050822
UniProt n/a n/a
RefSeq (mRNA) NM_001040661 NM_146257
RefSeq (protein) NP_001035751 NP_666369
Location (UCSC) n/a Chr 5:
142.96 - 142.98 Mb
PubMed search [1] [2]

Equilibrative nucleoside transporter 4 is a protein that in humans is encoded by the SLC29A4 gene.[1][2]

This gene is a member of the SLC29 family and encodes a plasma membrane protein with 11 transmembrane helices. This protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternate transcriptional splice variants which encode the same protein have been characterized.[2]

See also


  1. ^ Baldwin SA, Beal PR, Yao SY, King AE, Cass CE, Young JD (Feb 2004). "The equilibrative nucleoside transporter family, SLC29". Pflugers Arch 447 (5): 735-43. doi:10.1007/s00424-003-1103-2. PMID 12838422.  
  2. ^ a b "Entrez Gene: SLC29A4 solute carrier family 29 (nucleoside transporters), member 4".  

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Engel K, Zhou M, Wang J (2005). "Identification and characterization of a novel monoamine transporter in the human brain.". J. Biol. Chem. 279 (48): 50042–9. doi:10.1074/jbc.M407913200. PMID 15448143.  
  • Engel K, Wang J (2005). "Interaction of organic cations with a newly identified plasma membrane monoamine transporter.". Mol. Pharmacol. 68 (5): 1397–407. doi:10.1124/mol.105.016832. PMID 16099839.  
  • Barnes K, Dobrzynski H, Foppolo S, et al. (2006). "Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH.". Circ. Res. 99 (5): 510–9. doi:10.1161/01.RES.0000238359.18495.42. PMID 16873718.  
  • Xia L, Engel K, Zhou M, Wang J (2007). "Membrane localization and pH-dependent transport of a newly cloned organic cation transporter (PMAT) in kidney cells.". Am. J. Physiol. Renal Physiol. 292 (2): F682–90. doi:10.1152/ajprenal.00302.2006. PMID 17018840.  
  • Zhou M, Xia L, Engel K, Wang J (2007). "Molecular determinants of substrate selectivity of a novel organic cation transporter (PMAT) in the SLC29 family.". J. Biol. Chem. 282 (5): 3188–95. doi:10.1074/jbc.M609421200. PMID 17121826.  
  • Bottalico B, Noskova V, Pilka R, et al. (2007). "The organic cation transporters (OCT1, OCT2, EMT) and the plasma membrane monoamine transporter (PMAT) show differential distribution and cyclic expression pattern in human endometrium and early pregnancy decidua.". Mol. Reprod. Dev. 74 (10): 1303–11. doi:10.1002/mrd.20697. PMID 17393420.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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