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solute carrier family 30 (zinc transporter), member 1
Identifiers
Symbols SLC30A1; ZNT1; ZRC1
External IDs OMIM609521 MGI1345281 HomoloGene6681 GeneCards: SLC30A1 Gene
Orthologs
Species Human Mouse
Entrez 7779 22782
Ensembl ENSG00000170385 ENSMUSG00000037434
UniProt Q9Y6M5 Q60738
RefSeq (mRNA) NM_021194 NM_009579
RefSeq (protein) NP_067017 NP_033605
Location (UCSC) Chr 1:
209.82 - 209.82 Mb
Chr 1:
193.73 - 193.74 Mb
PubMed search [1] [2]

Solute carrier family 30 (zinc transporter), member 1 is a protein which in humans is encoded by the SLC30A1 gene.[1][2]

Function

SLC30A1 modulates zinc permeation through the L-type calcium channel. SLC30A1 downregulates not only Zn++ influx, but also Ca++ influx, thereby protecting cells from the effects of excessive cation permeation.[3]

References

  1. ^ Palmiter RD, Findley SD (February 1995). "Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc". The EMBO journal 14 (4): 639–49. PMID 7882967.  
  2. ^ Seve M, Chimienti F, Devergnas S, Favier A (May 2004). "In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression". BMC genomics 5 (1): 32. doi:10.1186/1471-2164-5-32. PMID 15154973.  
  3. ^ Segal D, Ohana E, Besser L, Hershfinkel M, Moran A, Sekler I (October 2004). "A role for ZnT-1 in regulating cellular cation influx". Biochemical and biophysical research communications 323 (4): 1145–50. doi:10.1016/j.bbrc.2004.08.211. PMID 15451416.  

Further reading

  • Guey LT, García-Closas M, Murta-Nascimento C, et al. (2009). "Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes.". Eur. Urol.: HASH(0x24ec9d0). doi:10.1016/j.eururo.2009.08.001. PMID 19692168.  
  • Zhang LH, Wang X, Stoltenberg M, et al. (2008). "Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain.". Brain Res. Bull. 77 (1): 55-60. doi:10.1016/j.brainresbull.2008.03.014. PMID 18639746.  
  • Lovell MA, Smith JL, Xiong S, Markesbery WR (2005). "Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease.". Neurotoxicity research 7 (4): 265-71. PMID 16179263.  
  • Zhang LY, Wang XL, Sun DX, et al. (2008). "Regulation of zinc transporters by dietary flaxseed lignan in human breast cancer xenografts.". Mol. Biol. Rep. 35 (4): 595-600. doi:10.1007/s11033-007-9129-8. PMID 17786585.  
  • Iguchi K, Otsuka T, Usui S, et al.. "Zinc and metallothionein levels and expression of zinc transporters in androgen-independent subline of LNCaP cells.". J. Androl. 25 (1): 154-61. PMID 14662799.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Lazarczyk M, Pons C, Mendoza JA, et al. (2008). "Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses.". J. Exp. Med. 205 (1): 35-42. doi:10.1084/jem.20071311. PMID 18158319.  
  • Overbeck S, Uciechowski P, Ackland ML, et al. (2008). "Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9.". J. Leukoc. Biol. 83 (2): 368-80. doi:10.1189/jlb.0307148. PMID 17971500.  
  • Hosgood HD, Menashe I, He X, et al. (2009). "PTEN identified as important risk factor of chronic obstructive pulmonary disease.". Respiratory medicine: HASH(0x15616e0). doi:10.1016/j.rmed.2009.06.016. PMID 19625176.  
  • Hosgood HD, Menashe I, Shen M, et al. (2008). "Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.". Carcinogenesis 29 (10): 1938-43. doi:10.1093/carcin/bgn178. PMID 18676680.  
  • Etzion Y, Ganiel A, Beharier O, et al. (2008). "Correlation between atrial ZnT-1 expression and atrial fibrillation in humans: a pilot study.". J. Cardiovasc. Electrophysiol. 19 (2): 157-64. doi:10.1111/j.1540-8167.2007.01008.x. PMID 17971132.  
  • Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome.". Mol. Cell Proteomics 7 (3): 499-508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.  
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