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Solute carrier family 30 (zinc transporter), member 8
Symbols SLC30A8; ZnT-8
External IDs OMIM*611145 MGI2442682 HomoloGene13795 GeneCards: SLC30A8 Gene
RNA expression pattern
PBB GE SLC30A8 gnf1h06210 at tn.png
More reference expression data
Species Human Mouse
Entrez 169026 239436
Ensembl ENSG00000164756 ENSMUSG00000022315
UniProt n/a n/a
RefSeq (mRNA) NM_173851 NM_172816
RefSeq (protein) NP_776250 NP_766404
Location (UCSC) Chr 8:
118.03 - 118.26 Mb
Chr 15:
52.13 - 52.17 Mb
PubMed search [1] [2]

Solute carrier family 30 (zinc transporter), member 8, also known as SLC30A8, is a human gene[1] that codes for a zinc transporter related to insulin secretion in humans. Certain alleles of this gene may be responsible for a large percentage of type 2 diabetes cases.


See also


Further reading

  • Chimienti F, Favier A, Seve M (2006). "ZnT-8, a pancreatic beta-cell-specific zinc transporter.". Biometals 18 (4): 313–7. doi:10.1007/s10534-005-3687-9. PMID 16158222.  
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMID 11076863.  
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Seve M, Chimienti F, Devergnas S, Favier A (2004). "In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression.". BMC Genomics 5 (1): 32. doi:10.1186/1471-2164-5-32. PMID 15154973.  
  • Chimienti F, Devergnas S, Favier A, Seve M (2004). "Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules.". Diabetes 53 (9): 2330–7. doi:10.2337/diabetes.53.9.2330. PMID 15331542.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.  
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.  
  • Sladek R, Rocheleau G, Rung J, et al. (2007). "A genome-wide association study identifies novel risk loci for type 2 diabetes.". Nature 445 (7130): 881–5. doi:10.1038/nature05616. PMID 17293876.  
  • Wenzlau JM, Juhl K, Yu L, et al. (2007). "The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes.". Proc. Natl. Acad. Sci. U.S.A. 104 (43): 17040–5. doi:10.1073/pnas.0705894104. PMID 17942684.  

External links



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