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Solute carrier family 36 (proton/amino acid symporter), member 1
Identifiers
Symbols SLC36A1; PAT1; LYAAT1; TRAMD3
External IDs OMIM606561 MGI2445299 HomoloGene70571 GeneCards: SLC36A1 Gene
RNA expression pattern
PBB GE SLC36A1 213119 at tn.png
PBB GE SLC36A1 gnf1h01641 at tn.png
PBB GE SLC36A1 gnf1h01642 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 206358 215335
Ensembl ENSG00000123643 ENSMUSG00000020261
UniProt Q7Z2H8 Q5F227
RefSeq (mRNA) NM_078483 NM_153139
RefSeq (protein) NP_510968 NP_694779
Location (UCSC) Chr 5:
150.81 - 150.85 Mb
Chr 11:
55.05 - 55.08 Mb
PubMed search [1] [2]

Proton-coupled amino acid transporter 1 is a protein that in humans is encoded by the SLC36A1 gene.[1][2][3]

This gene encodes a member of the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with related family members on chromosome 5q33.1.[3]

See also

References

  1. ^ Boll M, Foltz M, Rubio-Aliaga I, Kottra G, Daniel H (Jun 2002). "Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters". J Biol Chem 277 (25): 22966-73. doi:10.1074/jbc.M200374200. PMID 11959859.  
  2. ^ Sagne C, Agulhon C, Ravassard P, Darmon M, Hamon M, El Mestikawy S, Gasnier B, Giros B (Jun 2001). "Identification and characterization of a lysosomal transporter for small neutral amino acids". Proc Natl Acad Sci U S A 98 (13): 7206-11. doi:10.1073/pnas.121183498. PMID 11390972.  
  3. ^ a b "Entrez Gene: SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=206358.  

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMID 11076863.  
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.  
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.  
  • Chen Z, Fei YJ, Anderson CM, et al. (2003). "Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2.". J. Physiol. (Lond.) 546 (Pt 2): 349–61. doi:10.1113/jphysiol.2002.026500. PMID 12527723.  
  • Wreden CC, Johnson J, Tran C, et al. (2003). "The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons.". J. Neurosci. 23 (4): 1265–75. PMID 12598615.  
  • Boll M, Foltz M, Rubio-Aliaga I, Daniel H (2004). "A cluster of proton/amino acid transporter genes in the human and mouse genomes.". Genomics 82 (1): 47–56. doi:10.1016/S0888-7543(03)00099-5. PMID 12809675.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Bermingham JR, Pennington J (2004). "Organization and expression of the SLC36 cluster of amino acid transporter genes.". Mamm. Genome 15 (2): 114–25. doi:10.1007/s00335-003-2319-3. PMID 15058382.  
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.  
  • Anderson CM, Grenade DS, Boll M, et al. (2004). "H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat.". Gastroenterology 127 (5): 1410–22. doi:10.1053/j.gastro.2004.08.017. PMID 15521011.  
  • Anderson CM, Thwaites DT (2005). "Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1).". J. Cell. Physiol. 204 (2): 604–13. doi:10.1002/jcp.20337. PMID 15754324.  
  • Abbot EL, Grenade DS, Kennedy DJ, et al. (2006). "Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H+ -coupled amino-acid transporter hPAT1.". Br. J. Pharmacol. 147 (3): 298–306. doi:10.1038/sj.bjp.0706557. PMID 16331283.  
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.  
  • Kuan YH, Gruebl T, Soba P, et al. (2007). "PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2.". J. Biol. Chem. 281 (52): 40114–23. doi:10.1074/jbc.M605407200. PMID 17050537.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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