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SLC39A6: Wikis


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Solute carrier family 39 (zinc transporter), member 6
Symbols SLC39A6; LIV-1
External IDs OMIM608731 MGI2147279 HomoloGene8199 GeneCards: SLC39A6 Gene
RNA expression pattern
PBB GE SLC39A6 202088 at tn.png
PBB GE SLC39A6 202089 s at tn.png
More reference expression data
Species Human Mouse
Entrez 25800 106957
Ensembl ENSG00000141424 ENSMUSG00000024270
UniProt Q13433 Q8C145
RefSeq (mRNA) NM_012319 NM_139143
RefSeq (protein) NP_036451 NP_631882
Location (UCSC) Chr 18:
31.94 - 31.96 Mb
Chr 18:
24.72 - 24.75 Mb
PubMed search [1] [2]

Zinc transporter ZIP6 is a protein that in humans is encoded by the SLC39A6 gene.[1][2][3]

Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003).[supplied by OMIM][3]

See also


  1. ^ Taylor KM, Nicholson RI (Mar 2003). "The LZT proteins; the LIV-1 subfamily of zinc transporters". Biochim Biophys Acta 1611 (1-2): 16-30. PMID 12659941.  
  2. ^ Taylor KM, Morgan HE, Johnson A, Hadley LJ, Nicholson RI (Sep 2003). "Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters". Biochem J 375 (Pt 1): 51-9. doi:10.1042/BJ20030478. PMID 12839489.  
  3. ^ a b "Entrez Gene: SLC39A6 solute carrier family 39 (zinc transporter), member 6".  

Further reading

  • Manning DL, Daly RJ, Lord PG, et al. (1988). "Effects of oestrogen on the expression of a 4.4 kb mRNA in the ZR-75-1 human breast cancer cell line.". Mol. Cell. Endocrinol. 59 (3): 205–12. doi:10.1016/0303-7207(88)90105-0. PMID 2903103.  
  • Dressman MA, Walz TM, Lavedan C, et al. (2002). "Genes that co-cluster with estrogen receptor alpha in microarray analysis of breast biopsies.". Pharmacogenomics J. 1 (2): 135–41. PMID 11911440.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Schaner ME, Ross DT, Ciaravino G, et al. (2004). "Gene expression patterns in ovarian carcinomas.". Mol. Biol. Cell 14 (11): 4376–86. doi:10.1091/mbc.E03-05-0279. PMID 12960427.  
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Kasper G, Weiser AA, Rump A, et al. (2005). "Expression levels of the putative zinc transporter LIV-1 are associated with a better outcome of breast cancer patients.". Int. J. Cancer 117 (6): 961–73. doi:10.1002/ijc.21235. PMID 15986450.  
  • Zhao L, Chen W, Taylor KM, et al. (2007). "LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway.". Biochem. Biophys. Res. Commun. 363 (1): 82–8. doi:10.1016/j.bbrc.2007.08.127. PMID 17825787.  


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