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SLC39A7: Wikis


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Solute carrier family 39 (zinc transporter), member 7
Symbols SLC39A7; RING5; D6S115E; D6S2244E; H2-KE4; HKE4; KE4; ZIP7
External IDs OMIM601416 MGI95909 HomoloGene5072 GeneCards: SLC39A7 Gene
RNA expression pattern
PBB GE SLC39A7 202667 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7922 14977
Ensembl ENSG00000112473 ENSMUSG00000024327
UniProt Q92504 Q14C53
RefSeq (mRNA) NM_001077516 NM_001077709
RefSeq (protein) NP_001070984 NP_001071177
Location (UCSC) Chr 6:
33.28 - 33.28 Mb
Chr 17:
33.64 - 33.64 Mb
PubMed search [1] [2]

Zinc transporter SLC39A7 is a protein that in humans is encoded by the SLC39A7 gene.[1][2][3]

Zinc is an essential cofactor for more than 50 classes of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. Zinc cannot passively diffuse across cell membranes and requires specific transporters, such as SLC39A7, to enter the cytosol from both the extracellular environment and from intracellular storage compartments.[supplied by OMIM][3]

See also


  1. ^ Ando A, Kikuti YY, Shigenari A, Kawata H, Okamoto N, Shiina T, Chen L, Ikemura T, Abe K, Kimura M, Inoko H (Dec 1996). "cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region". Genomics 35 (3): 600-2. doi:10.1006/geno.1996.0405. PMID 8812499.  
  2. ^ Hanson IM, Trowsdale J (Aug 1991). "Colinearity of novel genes in the class II regions of the MHC in mouse and human". Immunogenetics 34 (1): 5-11. PMID 1855816.  
  3. ^ a b "Entrez Gene: SLC39A7 solute carrier family 39 (zinc transporter), member 7".  

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Taylor KM, Morgan HE, Johnson A, et al. (2003). "Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters.". Biochem. J. 375 (Pt 1): 51–9. doi:10.1042/BJ20030478. PMID 12839489.  
  • Taylor KM, Morgan HE, Johnson A, Nicholson RI (2004). "Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters.". Biochem. J. 377 (Pt 1): 131–9. doi:10.1042/BJ20031183. PMID 14525538.  
  • Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Huang L, Kirschke CP, Zhang Y, Yu YY (2005). "The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus.". J. Biol. Chem. 280 (15): 15456–63. doi:10.1074/jbc.M412188200. PMID 15705588.  
  • Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells.". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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