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solute carrier family 46 (folate transporter), member 1
Identifiers
Symbols SLC46A1; PCFT ; HCP1; MGC9564
External IDs OMIM611672 MGI1098733 HomoloGene41693 GeneCards: SLC46A1 Gene
RNA expression pattern
PBB GE PCFT gnf1h08403 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 113235 52466
Ensembl ENSG00000076351 ENSMUSG00000020829
UniProt Q96NT5 Q6PEM8
RefSeq (mRNA) NM_080669 NM_026740
RefSeq (protein) NP_542400 NP_081016
Location (UCSC) Chr 17:
23.75 - 23.76 Mb
Chr 11:
78.28 - 78.29 Mb
PubMed search [1] [2]

Solute carrier family 46 (folate transporter), member 1 (SLC46A1) also known as proton-coupled folate transporter (PCFT), is a protein which in humans is encoded by the SLC46A1 gene.[1][2][3]

Contents

Function

SLC46A1 is responsible for the intestinal uptake of folate.[4]

References

  1. ^ "Entrez Gene: PCFT proton-coupled folate transporter". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=113235.  
  2. ^ Shayeghi M, Latunde-Dada GO, Oakhill JS, Laftah AH, Takeuchi K, Halliday N, Khan Y, Warley A, McCann FE, Hider RC, Frazer DM, Anderson GJ, Vulpe CD, Simpson RJ, McKie AT (September 2005). "Identification of an intestinal heme transporter". Cell 122 (5): 789–801. doi:10.1016/j.cell.2005.06.025. PMID 16143108.  
  3. ^ Sharma S, Dimasi D, Bröer S, Kumar R, Della NG (April 2007). "Heme carrier protein 1 (HCP1) expression and functional analysis in the retina and retinal pigment epithelium". Exp. Cell Res. 313 (6): 1251–9. doi:10.1016/j.yexcr.2007.01.019. PMID 17335806.  
  4. ^ Nakai Y, Inoue K, Abe N, Hatakeyama M, Ohta KY, Otagiri M, Hayashi Y, Yuasa H (August 2007). "Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter". J. Pharmacol. Exp. Ther. 322 (2): 469–76. doi:10.1124/jpet.107.122606. PMID 17475902.  

External links

Further reading

  • Subramanian VS, Marchant JS, Said HM (2008). "Apical membrane targeting and trafficking of the human proton-coupled transporter in polarized epithelia.". Am. J. Physiol., Cell Physiol. 294 (1): C233–40. doi:10.1152/ajpcell.00468.2007. PMID 18003745.  
  • Nakai Y, Inoue K, Abe N, et al. (2007). "Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter.". J. Pharmacol. Exp. Ther. 322 (2): 469–76. doi:10.1124/jpet.107.122606. PMID 17475902.  
  • Zhao R, Min SH, Qiu A, et al. (2007). "The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption.". Blood 110 (4): 1147–52. doi:10.1182/blood-2007-02-077099. PMID 17446347.  
  • Sharma S, Dimasi D, Bröer S, et al. (2007). "Heme carrier protein 1 (HCP1) expression and functional analysis in the retina and retinal pigment epithelium.". Exp. Cell Res. 313 (6): 1251–9. doi:10.1016/j.yexcr.2007.01.019. PMID 17335806.  
  • Latunde-Dada GO, Takeuchi K, Simpson RJ, McKie AT (2007). "Haem carrier protein 1 (HCP1): Expression and functional studies in cultured cells.". FEBS Lett. 580 (30): 6865–70. doi:10.1016/j.febslet.2006.11.048. PMID 17156779.  
  • Qiu A, Jansen M, Sakaris A, et al. (2007). "Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption.". Cell 127 (5): 917–28. doi:10.1016/j.cell.2006.09.041. PMID 17129779.  
  • Shayeghi M, Latunde-Dada GO, Oakhill JS, et al. (2005). "Identification of an intestinal heme transporter.". Cell 122 (5): 789–801. doi:10.1016/j.cell.2005.06.025. PMID 16143108.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
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