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Solute carrier family 47, member 2
Identifiers
Symbols SLC47A2; MATE2; FLJ31196
External IDs OMIM609833 HomoloGene87116 GeneCards: SLC47A2 Gene
Orthologs
Species Human Mouse
Entrez 146802 n/a
Ensembl ENSG00000180638 n/a
UniProt n/a n/a
RefSeq (mRNA) NM_152908 n/a
RefSeq (protein) NP_690872 n/a
Location (UCSC) Chr 17:
19.52 - 19.56 Mb
n/a
PubMed search [1] n/a

Solute carrier family 47, member 2, also known as SLC47A2, is a protein which in humans is encoded by the SLC47A2 gene.[1]

Contents

Function

This gene encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE (multi antimicrobial extrusion protein or multidrug and toxic compound extrusion) protein family responsible for drug resistance.[2] This gene is one of two members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[1]

Discovery

The multidrug efflux transporter NorM from V. parahaemolyticus which mediates resistance to multiple antimicrobial agents (norfloxacin, kanamycin, ethidium bromide etc) and its homologue from E. coli were identified in 1998.[2] NorM seems to function as drug/sodium antiporter which is the first example of Na+-coupled multidrug efflux transporter discovered.[3] NorM is a prototype of a new transporter family and Brown et al. named it the multidrug and toxic compound extrusion family.[4]

References

  1. ^ a b "Entrez Gene: MATE2 H+/organic cation antiporter". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=146802.  
  2. ^ a b Morita Y, Kodama K, Shiota S, Mine T, Kataoka A, Mizushima T, Tsuchiya T (July 1998). "NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli". Antimicrob. Agents Chemother. 42 (7): 1778–82. PMID 9661020.  
  3. ^ Morita Y, Kataoka A, Shiota S, Mizushima T, Tsuchiya T (December 2000). "NorM of vibrio parahaemolyticus is an Na(+)-driven multidrug efflux pump". J. Bacteriol. 182 (23): 6694–7. PMID 11073914.  
  4. ^ Brown MH, Paulsen IT, Skurray RA (January 1999). "The multidrug efflux protein NorM is a prototype of a new family of transporters". Mol. Microbiol. 31 (1): 394–5. PMID 9987140.  

Further reading

  • Tanihara Y, Masuda S, Sato T, et al. (2007). "Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.". Biochem. Pharmacol. 74 (2): 359–71. doi:10.1016/j.bcp.2007.04.010. PMID 17509534.  
  • Omote H, Hiasa M, Matsumoto T, et al. (2007). "The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations.". Trends Pharmacol. Sci. 27 (11): 587–93. doi:10.1016/j.tips.2006.09.001. PMID 16996621.  
  • Masuda S, Terada T, Yonezawa A, et al. (2006). "Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.". J. Am. Soc. Nephrol. 17 (8): 2127–35. doi:10.1681/ASN.2006030205. PMID 16807400.  
  • Otsuka M, Matsumoto T, Morimoto R, et al. (2006). "A human transporter protein that mediates the final excretion step for toxic organic cations.". Proc. Natl. Acad. Sci. U.S.A. 102 (50): 17923–8. doi:10.1073/pnas.0506483102. PMID 16330770.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome.". Science 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.  
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  
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