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SLC4A3: Wikis


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Solute carrier family 4, anion exchanger, member 3
Symbols SLC4A3; AE3; SLC2C
External IDs OMIM106195 MGI109350 HomoloGene38005 GeneCards: SLC4A3 Gene
RNA expression pattern
PBB GE SLC4A3 205918 at tn.png
More reference expression data
Species Human Mouse
Entrez 6508 20536
Ensembl ENSG00000114923 ENSMUSG00000006576
UniProt P48751 Q68EG4
RefSeq (mRNA) NM_005070 NM_009208
RefSeq (protein) NP_005061 NP_033234
Location (UCSC) Chr 2:
220.2 - 220.21 Mb
Chr 1:
75.43 - 75.44 Mb
PubMed search [1] [2]

Anion exchange protein 3 is a protein that in humans is encoded by the SLC4A3 gene.[1][2]

See also


  1. ^ Su YR, Klanke CA, Houseal TW, Linn SC, Burk SE, Varvil TS, Otterud BE, Shull GE, Leppert MF, Menon AG (Jan 1995). "Molecular cloning and physical and genetic mapping of the human anion exchanger isoform 3 (SLC2C) gene to chromosome 2q36". Genomics 22 (3): 605-9. doi:10.1006/geno.1994.1433. PMID 8001971.  
  2. ^ "Entrez Gene: SLC4A3 solute carrier family 4, anion exchanger, member 3".  

Further reading

  • Alper SL, Chernova MN, Stewart AK (2002). "Regulation of Na+-independent Cl-/HCO3- exchangers by pH.". JOP 2 (4 Suppl): 171–5. PMID 11875255.  
  • Alper SL, Darman RB, Chernova MN, Dahl NK (2002). "The AE gene family of Cl/HCO3- exchangers.". J. Nephrol. 15 Suppl 5: S41–53. PMID 12027221.  
  • Kopito RR, Lee BS, Simmons DM, et al. (1990). "Regulation of intracellular pH by a neuronal homolog of the erythrocyte anion exchanger.". Cell 59 (5): 927–37. doi:10.1016/0092-8674(89)90615-6. PMID 2686841.  
  • Yannoukakos D, Stuart-Tilley A, Fernandez HA, et al. (1994). "Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart.". Circ. Res. 75 (4): 603–14. PMID 7923606.  
  • Morgans CW, Kopito RR (1993). "Association of the brain anion exchanger, AE3, with the repeat domain of ankyrin.". J. Cell. Sci. 105 ( Pt 4): 1137–42. PMID 8227202.  
  • Dudeja PK, Hafez N, Tyagi S, et al. (1999). "Expression of the Na+/H+ and Cl-/HCO-3 exchanger isoforms in proximal and distal human airways.". Am. J. Physiol. 276 (6 Pt 1): L971–8. PMID 10362722.  
  • Einum DD, Zhang J, Arneson PJ, et al. (2000). "Genomic structure of human anion exchanger 3 and its potential role in hereditary neurological disease.". Neurogenetics 1 (4): 289–92. doi:10.1007/s100480050043. PMID 10732805.  
  • Soleimani M, Greeley T, Petrovic S, et al. (2001). "Pendrin: an apical Cl-/OH-/HCO3- exchanger in the kidney cortex.". Am. J. Physiol. Renal Physiol. 280 (2): F356–64. PMID 11208611.  
  • Alrefai WA, Tyagi S, Nazir TM, et al. (2001). "Human intestinal anion exchanger isoforms: expression, distribution, and membrane localization.". Biochim. Biophys. Acta 1511 (1): 17–27. doi:10.1016/S0005-2736(00)00366-7. PMID 11248201.  
  • Sterling D, Reithmeier RA, Casey JR (2002). "A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers.". J. Biol. Chem. 276 (51): 47886–94. doi:10.1074/jbc.M105959200. PMID 11606574.  
  • Alvarez BV, Fujinaga J, Casey JR (2002). "Molecular basis for angiotensin II-induced increase of chloride/bicarbonate exchange in the myocardium.". Circ. Res. 89 (12): 1246–53. doi:10.1161/hh2401.101907. PMID 11739292.  
  • Wang Z, Petrovic S, Mann E, Soleimani M (2002). "Identification of an apical Cl(-)/HCO3(-) exchanger in the small intestine.". Am. J. Physiol. Gastrointest. Liver Physiol. 282 (3): G573–9. doi:10.1152/ajpgi.00338.2001. PMID 11842009.  
  • Al-Bazzaz FJ, Hafez N, Tyagi S, et al. (2002). "Detection of Cl--HCO3- and Na+-H+ exchangers in human airways epithelium.". JOP 2 (4 Suppl): 285–90. PMID 11875273.  
  • Sterling D, Alvarez BV, Casey JR (2002). "The extracellular component of a transport metabolon. Extracellular loop 4 of the human AE1 Cl-/HCO3- exchanger binds carbonic anhydrase IV.". J. Biol. Chem. 277 (28): 25239–46. doi:10.1074/jbc.M202562200. PMID 11994299.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  


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