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SLC4A5: Wikis


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Solute carrier family 4, sodium bicarbonate cotransporter, member 5
Symbols SLC4A5; MGC129662; NBC4
External IDs OMIM606757 MGI2443220 HomoloGene71686 GeneCards: SLC4A5 Gene
RNA expression pattern
PBB GE SLC4A5 221723 s at tn.png
More reference expression data
Species Human Mouse
Entrez 57835 232156
Ensembl ENSG00000188687 n/a
UniProt n/a n/a
RefSeq (mRNA) NM_033323 XM_888058
RefSeq (protein) NP_201580 XP_893151
Location (UCSC) Chr 2:
74.3 - 74.42 Mb
PubMed search [1] [2]

Electrogenic sodium bicarbonate cotransporter 4 is a protein that in humans is encoded by the SLC4A5 gene.[1][2][3]

This gene encodes a member of the sodium bicarbonate cotransporter (NBC) family, part of the bicarbonate transporter superfamily. Sodium bicarbonate cotransporters are involved in intracellular pH regulation and electroneural or electrogenic sodium bicarbonate transport. This protein is thought to be an integral membrane protein. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.[3]

See also


  1. ^ Pushkin A, Abuladze N, Newman D, Lee I, Xu G, Kurtz I (Nov 2000). "Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family". Biochim Biophys Acta 1493 (1-2): 215-8. PMID 10978526.  
  2. ^ Pushkin A, Abuladze N, Newman D, Lee I, Xu G, Kurtz I (Mar 2001). "Two C-terminal variants of NBC4, a new member of the sodium bicarbonate cotransporter family: cloning, characterization, and localization". IUBMB Life 50 (1): 13-9. doi:10.1080/15216540050176539. PMID 11087115.  
  3. ^ a b "Entrez Gene: SLC4A5 solute carrier family 4, sodium bicarbonate cotransporter, member 5".  

Further reading

  • Soleimani M, Burnham CE (2002). "Na+:HCO(3-) cotransporters (NBC): cloning and characterization.". J. Membr. Biol. 183 (2): 71–84. doi:10.1007/s00232-001-0055-8. PMID 11562789.  
  • Hunt SC, Xin Y, Wu LL, et al. (2006). "Sodium bicarbonate cotransporter polymorphisms are associated with baseline and 10-year follow-up blood pressures.". Hypertension 47 (3): 532–6. doi:10.1161/01.HYP.0000196949.26088.3c. PMID 16365189.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Xu J, Wang Z, Barone S, et al. (2003). "Expression of the Na+-HCO-3 cotransporter NBC4 in rat kidney and characterization of a novel NBC4 variant.". Am. J. Physiol. Renal Physiol. 284 (1): F41–50. doi:10.1152/ajprenal.00055.2002 (inactive 2008-12-12). PMID 12388414.  
  • Pushkin A, Abuladze N, Newman D, et al. (2002). "Genomic organization of the DCTN1-SLC4A5 locus encoding both NBC4 and p150(Glued).". Cytogenet. Cell Genet. 95 (3-4): 163–8. doi:10.1159/000059340. PMID 12063394.  
  • Sassani P, Pushkin A, Gross E, et al. (2002). "Functional characterization of NBC4: a new electrogenic sodium-bicarbonate cotransporter.". Am. J. Physiol., Cell Physiol. 282 (2): C408–16. doi:10.1152/ajpcell.00409.2001 (inactive 2008-12-12). PMID 11788353.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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