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Solute carrier family 4, sodium bicarbonate cotransporter, member 8
Identifiers
Symbols SLC4A8; NBC3; DKFZp761B2318; FLJ46462
External IDs OMIM605024 MGI1928745 HomoloGene68419 GeneCards: SLC4A8 Gene
RNA expression pattern
PBB GE SLC4A8 207056 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9498 59033
Ensembl ENSG00000050438 ENSMUSG00000023032
UniProt n/a n/a
RefSeq (mRNA) NM_001039960 NM_001033218
RefSeq (protein) NP_001035049 NP_001028390
Location (UCSC) Chr 12:
50.07 - 50.18 Mb
Chr 15:
100.59 - 100.64 Mb
PubMed search [1] [2]

Electroneutral sodium bicarbonate exchanger 1 is a protein that in humans is encoded by the SLC4A8 gene.[1][2]

Contents

See also

Interactions

SLC4A8 has been shown to interact with Sodium-hydrogen antiporter 3 regulator 1[3][4] and Cystic fibrosis transmembrane conductance regulator.[4]

References

  1. ^ Grichtchenko II, Choi I, Zhong X, Bray-Ward P, Russell JM, Boron WF (May 2001). "Cloning, characterization, and chromosomal mapping of a human electroneutral Na(+)-driven Cl-HCO3 exchanger". J Biol Chem 276 (11): 8358–63. doi:10.1074/jbc.C000716200. PMID 11133997.  
  2. ^ "Entrez Gene: SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9498.  
  3. ^ Pushkin, Alexander; Abuladze Natalia, Newman Debra, Muronets Vladimir, Sassani Pejvak, Tatishchev Sergei, Kurtz Ira (Mar. 2003). "The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction". Am. J. Physiol., Cell Physiol. (United States) 284 (3): C667-73. doi:10.1152/ajpcell.00225.2002. ISSN 0363-6143. PMID 12444018.  
  4. ^ a b Park, Meeyoung; Ko Shigeru B H, Choi Joo Young, Muallem Gaia, Thomas Philip J, Pushkin Alexander, Lee Myeong-Sok, Kim Joo Young, Lee Min Goo, Muallem Shmuel, Kurtz Ira (Dec. 2002). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3". J. Biol. Chem. (United States) 277 (52): 50503–9. doi:10.1074/jbc.M201862200. ISSN 0021-9258. PMID 12403779.  

Further reading

  • Soleimani M (2002). "Na+:HCO3- cotransporters (NBC): expression and regulation in the kidney.". J. Nephrol. 15 Suppl 5: S32–40. PMID 12027220.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Loiselle FB, Morgan PE, Alvarez BV, Casey JR (2004). "Regulation of the human NBC3 Na+/HCO3- cotransporter by carbonic anhydrase II and PKA.". Am. J. Physiol., Cell Physiol. 286 (6): C1423–33. doi:10.1152/ajpcell.00382.2003. PMID 14736710.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Pushkin A, Abuladze N, Newman D, et al. (2003). "The COOH termini of NBC3 and the 56-kDa H+-ATPase subunit are PDZ motifs involved in their interaction.". Am. J. Physiol., Cell Physiol. 284 (3): C667–73. doi:10.1152/ajpcell.00225.2002. PMID 12444018.  
  • Park M, Ko SB, Choi JY, et al. (2003). "The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3.". J. Biol. Chem. 277 (52): 50503–9. doi:10.1074/jbc.M201862200. PMID 12403779.  
  • Gresz V, Kwon TH, Vorum H, et al. (2002). "Immunolocalization of electroneutral Na(+)-HCO cotransporters in human and rat salivary glands.". Am. J. Physiol. Gastrointest. Liver Physiol. 283 (2): G473–80. doi:10.1152/ajpgi.00421.2001. PMID 12121896.  
  • Amlal H, Burnham CE, Soleimani M (1999). "Characterization of Na+/HCO-3 cotransporter isoform NBC-3.". Am. J. Physiol. 276 (6 Pt 2): F903–13. PMID 10362779.  
  • Pushkin A, Abuladze N, Lee I, et al. (1999). "Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family.". J. Biol. Chem. 274 (23): 16569–75. doi:10.1074/jbc.274.23.16569. PMID 10347222.  
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.  
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