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Solute carrier family 5 (sodium/glucose cotransporter), member 1
Symbols SLC5A1; D22S675; NAGT; SGLT1
External IDs OMIM182380 MGI107678 HomoloGene55456 GeneCards: SLC5A1 Gene
RNA expression pattern
PBB GE SLC5A1 206628 at tn.png
More reference expression data
Species Human Mouse
Entrez 6523 20537
Ensembl ENSG00000100170 ENSMUSG00000011034
UniProt P13866 O70122
RefSeq (mRNA) NM_000343 NM_019810
RefSeq (protein) NP_000334 NP_062784
Location (UCSC) Chr 22:
30.77 - 30.84 Mb
Chr 5:
33.42 - 33.48 Mb
PubMed search [1] [2]

Sodium/glucose cotransporter 1 is a protein that in humans is encoded by the SLC5A1 gene.[1][2]

Glucose transporters are integral membrane proteins that mediate the transport of glucose and structurally-related substances across cellular membranes. Two families of glucose transporter have been identified: the facilitated diffusion glucose transporter family (GLUT family), also known as 'uniporters,' and the sodium-dependent glucose transporter family (SGLT family), also known as 'cotransporters' or 'symporters' (Wright et al., 1994). The SLC5A1 gene encodes a protein that is involved in the active transport of glucose and galactose into eukaryotic and some prokaryotic cells. [supplied by OMIM][2]


See also


SLC5A1 has been shown to interact with PAWR.[3]


  1. ^ Turk E, Martin MG, Wright EM (Jun 1994). "Structure of the human Na+/glucose cotransporter gene SGLT1". J Biol Chem 269 (21): 15204–9. PMID 8195156.  
  2. ^ a b "Entrez Gene: SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1".  
  3. ^ Xie, Jun; Guo Qing (Jul. 2004). "Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane". J. Biol. Chem. (United States) 279 (27): 28266–75. doi:10.1074/jbc.M401495200. ISSN 0021-9258. PMID 15090548.  

Further reading

  • Wright EM, Loo DD, Panayotova-Heiermann M, et al. (1995). "'Active' sugar transport in eukaryotes.". J. Exp. Biol. 196: 197–212. PMID 7823022.  
  • Wright EM, Turk E, Martin MG (2003). "Molecular basis for glucose-galactose malabsorption.". Cell Biochem. Biophys. 36 (2-3): 115–21. doi:10.1385/CBB:36:2-3:115. PMID 12139397.  
  • Anderson NL, Anderson NG (2003). "The human plasma proteome: history, character, and diagnostic prospects.". Mol. Cell Proteomics 1 (11): 845–67. PMID 12488461.  
  • Turk E, Zabel B, Mundlos S, et al. (1991). "Glucose/galactose malabsorption caused by a defect in the Na+/glucose cotransporter.". Nature 350 (6316): 354–6. doi:10.1038/350354a0. PMID 2008213.  
  • Hediger MA, Turk E, Wright EM (1989). "Homology of the human intestinal Na+/glucose and Escherichia coli Na+/proline cotransporters.". Proc. Natl. Acad. Sci. U.S.A. 86 (15): 5748–52. doi:10.1073/pnas.86.15.5748. PMID 2490366.  
  • Delézay O, Baghdiguian S, Fantini J (1995). "The development of Na(+)-dependent glucose transport during differentiation of an intestinal epithelial cell clone is regulated by protein kinase C.". J. Biol. Chem. 270 (21): 12536–41. doi:10.1074/jbc.270.21.12536. PMID 7759499.  
  • Turk E, Klisak I, Bacallao R, et al. (1993). "Assignment of the human Na+/glucose cotransporter gene SGLT1 to chromosome 22q13.1.". Genomics 17 (3): 752–4. doi:10.1006/geno.1993.1399. PMID 8244393.  
  • Martín MG, Turk E, Lostao MP, et al. (1996). "Defects in Na+/glucose cotransporter (SGLT1) trafficking and function cause glucose-galactose malabsorption.". Nat. Genet. 12 (2): 216–20. doi:10.1038/ng0296-216. PMID 8563765.  
  • Turk E, Kerner CJ, Lostao MP, Wright EM (1996). "Membrane topology of the human Na+/glucose cotransporter SGLT1.". J. Biol. Chem. 271 (4): 1925–34. doi:10.1074/jbc.271.4.1925. PMID 8567640.  
  • Lam JT, Martín MG, Turk E, et al. (1999). "Missense mutations in SGLT1 cause glucose-galactose malabsorption by trafficking defects.". Biochim. Biophys. Acta 1453 (2): 297–303. PMID 10036327.  
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.  
  • Obermeier S, Hüselweh B, Tinel H, et al. (2001). "Expression of glucose transporters in lactating human mammary gland epithelial cells.". European journal of nutrition 39 (5): 194–200. doi:10.1007/s003940070011. PMID 11131365.  
  • Kasahara M, Maeda M, Hayashi S, et al. (2001). "A missense mutation in the Na(+)/glucose cotransporter gene SGLT1 in a patient with congenital glucose-galactose malabsorption: normal trafficking but inactivation of the mutant protein.". Biochim. Biophys. Acta 1536 (2-3): 141–7. PMID 11406349.  
  • Roll P, Massacrier A, Pereira S, et al. (2002). "New human sodium/glucose cotransporter gene (KST1): identification, characterization, and mutation analysis in ICCA (infantile convulsions and choreoathetosis) and BFIC (benign familial infantile convulsions) families.". Gene 285 (1-2): 141–8. doi:10.1016/S0378-1119(02)00416-X. PMID 12039040.  
  • Ikari A, Nakano M, Kawano K, Suketa Y (2002). "Up-regulation of sodium-dependent glucose transporter by interaction with heat shock protein 70.". J. Biol. Chem. 277 (36): 33338–43. doi:10.1074/jbc.M200310200. PMID 12082088.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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