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SLC5A3: Wikis


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Solute carrier family 5 (inositol transporters), member 3
Symbols SLC5A3; SMIT; SMIT2
External IDs OMIM600444 MGI1858226 HomoloGene31412 GeneCards: SLC5A3 Gene
Species Human Mouse
Entrez 6526 53881
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) NM_006933 NM_017391
RefSeq (protein) NP_008864 NP_059087
Location (UCSC) n/a n/a
PubMed search [1] [2]

Sodium/myo-inositol cotransporter is a protein that in humans is encoded by the SLC5A3 gene.[1][2]

See also


  1. ^ Berry GT, Mallee JJ, Kwon HM, Rim JS, Mulla WR, Muenke M, Spinner NB (Jul 1995). "The human osmoregulatory Na+/myo-inositol cotransporter gene (SLC5A3): molecular cloning and localization to chromosome 21". Genomics 25 (2): 507-13. PMID 7789985.  
  2. ^ "Entrez Gene: SLC5A3 solute carrier family 5 (inositol transporters), member 3".  

Further reading

  • Kwon HM, Yamauchi A, Uchida S, et al. (1992). "Cloning of the cDNa for a Na+/myo-inositol cotransporter, a hypertonicity stress protein.". J. Biol. Chem. 267 (9): 6297–301. PMID 1372904.  
  • Berry GT, Mallee JJ, Blouin JL, Antonarakis SE (1996). "The 21q22.1 STS marker, VN02 (EST00541 cDNA), is part of the 3' sequence of the human Na+/myo-inositol cotransporter (SLC5A3) gene.". Cytogenet. Cell Genet. 73 (1-2): 77–8. doi:10.1159/000134311. PMID 8646889.  
  • Mallee JJ, Atta MG, Lorica V, et al. (1998). "The structural organization of the human Na+/myo-inositol cotransporter (SLC5A3) gene and characterization of the promoter.". Genomics 46 (3): 459–65. doi:10.1006/geno.1997.5055. PMID 9441750.  
  • Porcellati F, Hlaing T, Togawa M, et al. (1998). "Human Na(+)-myo-inositol cotransporter gene: alternate splicing generates diverse transcripts.". Am. J. Physiol. 274 (5 Pt 1): C1215–25. PMID 9612208.  
  • Rim JS, Atta MG, Dahl SC, et al. (1998). "Transcription of the sodium/myo-inositol cotransporter gene is regulated by multiple tonicity-responsive enhancers spread over 50 kilobase pairs in the 5'-flanking region.". J. Biol. Chem. 273 (32): 20615–21. doi:10.1074/jbc.273.32.20615. PMID 9685419.  
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  
  • Thangaraju M, Gopal E, Martin PM, et al. (2007). "SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases.". Cancer Res. 66 (24): 11560–4. doi:10.1158/0008-5472.CAN-06-1950. PMID 17178845.  


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