The Full Wiki

More info on SLC5A8

SLC5A8: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Solute carrier family 5 (iodide transporter), member 8
Symbols SLC5A8; AIT; MGC125354; SMCT
External IDs OMIM608044 MGI2384916 HomoloGene64832 GeneCards: SLC5A8 Gene
RNA expression pattern
PBB GE SLC5A8 gnf1h02682 at tn.png
PBB GE SLC5A8 gnf1h06296 at tn.png
PBB GE SLC5A8 gnf1h06297 s at tn.png
More reference expression data
Species Human Mouse
Entrez 160728 216225
Ensembl ENSG00000139357 n/a
UniProt n/a n/a
RefSeq (mRNA) NM_145913 XM_001001565
RefSeq (protein) NP_666018 XP_001001565
Location (UCSC) Chr 12:
100.07 - 100.13 Mb
PubMed search [1] [2]

Sodium-coupled monocarboxylate transporter 1 is a protein that in humans is encoded by the SLC5A8 gene.[1][2][3]

See also


  1. ^ Rodriguez AM, Perron B, Lacroix L, Caillou B, Leblanc G, Schlumberger M, Bidart JM, Pourcher T (Jul 2002). "Identification and characterization of a putative human iodide transporter located at the apical membrane of thyrocytes". J Clin Endocrinol Metab 87 (7): 3500-3. PMID 12107270.  
  2. ^ Li H, Myeroff L, Smiraglia D, Romero MF, Pretlow TP, Kasturi L, Lutterbaugh J, Rerko RM, Casey G, Issa JP, Willis J, Willson JK, Plass C, Markowitz SD (Jul 2003). "SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers". Proc Natl Acad Sci U S A 100 (14): 8412-7. doi:10.1073/pnas.1430846100. PMID 12829793.  
  3. ^ "Entrez Gene: SLC5A8 solute carrier family 5 (iodide transporter), member 8".  

Further reading

  • Gupta N, Martin PM, Prasad PD, Ganapathy V (2006). "SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter.". Life Sci. 78 (21): 2419–25. doi:10.1016/j.lfs.2005.10.028. PMID 16375929.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Miyauchi S, Gopal E, Fei YJ, Ganapathy V (2004). "Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids.". J. Biol. Chem. 279 (14): 13293–6. doi:10.1074/jbc.C400059200. PMID 14966140.  
  • Lacroix L, Pourcher T, Magnon C, et al. (2004). "Expression of the apical iodide transporter in human thyroid tissues: a comparison study with other iodide transporters.". J. Clin. Endocrinol. Metab. 89 (3): 1423–8. doi:10.1210/jc.2003-030542. PMID 15001644.  
  • Hong C, Maunakea A, Jun P, et al. (2005). "Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8.". Cancer Res. 65 (9): 3617–23. doi:10.1158/0008-5472.CAN-05-0048. PMID 15867356.  
  • Paroder V, Spencer SR, Paroder M, et al. (2006). "Na(+)/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: molecular characterization of SMCT.". Proc. Natl. Acad. Sci. U.S.A. 103 (19): 7270–5. doi:10.1073/pnas.0602365103. PMID 16670197.  
  • Hu S, Liu D, Tufano RP, et al. (2006). "Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer.". Int. J. Cancer 119 (10): 2322–9. doi:10.1002/ijc.22110. PMID 16858683.  
  • Gopal E, Miyauchi S, Martin PM, et al. (2007). "Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract.". Pharm. Res. 24 (3): 575–84. doi:10.1007/s11095-006-9176-1. PMID 17245649.  
  • Coady MJ, Wallendorff B, Bourgeois F, et al. (2007). "Establishing a definitive stoichiometry for the Na+/monocarboxylate cotransporter SMCT1.". Biophys. J. 93 (7): 2325–31. doi:10.1529/biophysj.107.108555. PMID 17526579.  


Got something to say? Make a comment.
Your name
Your email address