The Full Wiki

More info on SLC7A1

SLC7A1: Wikis


Note: Many of our articles have direct quotes from sources you can cite, within the Wikipedia article! This article doesn't yet, but we're working on it! See more info or our list of citable articles.


From Wikipedia, the free encyclopedia

Solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
Symbols SLC7A1; ATRC1; CAT-1; ERR; HCAT1; REC1L
External IDs OMIM104615 MGI88117 HomoloGene20658 GeneCards: SLC7A1 Gene
RNA expression pattern
PBB GE SLC7A1 206566 at tn.png
PBB GE SLC7A1 212290 at tn.png
PBB GE SLC7A1 212292 at tn.png
More reference expression data
Species Human Mouse
Entrez 6541 11987
Ensembl ENSG00000139514 ENSMUSG00000041313
UniProt P30825 Q3TQZ8
RefSeq (mRNA) NM_003045 NM_007513
RefSeq (protein) NP_003036 NP_031539
Location (UCSC) Chr 13:
28.98 - 29.07 Mb
Chr 5:
148.64 - 148.71 Mb
PubMed search [1] [2]

High affinity cationic amino acid transporter 1 is a protein that in humans is encoded by the SLC7A1 gene.[1][2]

See also


  1. ^ Albritton LM, Bowcock AM, Eddy RL, Morton CC, Tseng L, Farrer LA, Cavalli-Sforza LL, Shows TB, Cunningham JM (May 1992). "The human cationic amino acid transporter (ATRC1): physical and genetic mapping to 13q12-q14". Genomics 12 (3): 430-4. PMID 1348489.  
  2. ^ "Entrez Gene: SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1".  

Further reading

  • Yoshimoto T, Yoshimoto E, Meruelo D (1991). "Molecular cloning and characterization of a novel human gene homologous to the murine ecotropic retroviral receptor.". Virology 185 (1): 10–7. doi:10.1016/0042-6822(91)90748-Z. PMID 1718082.  
  • Kamath SG, Furesz TC, Way BA, Smith CH (1999). "Identification of three cationic amino acid transporters in placental trophoblast: cloning, expression, and characterization of hCAT-1.". J. Membr. Biol. 171 (1): 55–62. doi:10.1007/s002329900558. PMID 10485994.  
  • Hammermann R, Brunn G, Racké K (2002). "Analysis of the genomic organization of the human cationic amino acid transporters CAT-1, CAT-2 and CAT-4.". Amino Acids 21 (2): 211–9. doi:10.1007/s007260170029. PMID 11665818.  
  • Cariappa R, Heath-Monnig E, Furesz TC, et al. (2002). "Stable polarized expression of hCAT-1 in an epithelial cell line.". J. Membr. Biol. 186 (1): 23–30. doi:10.1007/s00232-001-0133-y. PMID 11891586.  
  • Furesz TC, Heath-Monnig E, Kamath SG, Smith CH (2003). "Lysine uptake by cloned hCAT-2B: comparison with hCAT-1 and with trophoblast surface membranes.". J. Membr. Biol. 189 (1): 27–33. doi:10.1007/s00232-002-1001-0. PMID 12202949.  
  • Kizhatil K, Albritton LM (2002). "System y+ localizes to different membrane subdomains in the basolateral plasma membrane of epithelial cells.". Am. J. Physiol., Cell Physiol. 283 (6): C1784–94. doi:10.1152/ajpcell.00061.2002. PMID 12388095.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Schnorr O, Suschek CV, Kolb-Bachofen V (2003). "The importance of cationic amino acid transporter expression in human skin.". J. Invest. Dermatol. 120 (6): 1016–22. doi:10.1046/j.1523-1747.2003.12139.x. PMID 12787129.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMID 15057823.  
  • González M, Flores C, Pearson JD, et al. (2005). "Cell signalling-mediating insulin increase of mRNA expression for cationic amino acid transporters-1 and -2 and membrane hyperpolarization in human umbilical vein endothelial cells.". Pflugers Arch. 448 (4): 383–94. doi:10.1007/s00424-004-1261-x. PMID 15064952.  
  • Schwartz IF, Iaina A, Benedict Y, et al. (2004). "Augmented arginine uptake, through modulation of cationic amino acid transporter-1, increases GFR in diabetic rats.". Kidney Int. 65 (4): 1311–9. doi:10.1111/j.1523-1755.2004.00508.x. PMID 15086470.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Rotmann A, Strand D, Martiné U, Closs EI (2005). "Protein kinase C activation promotes the internalization of the human cationic amino acid transporter hCAT-1. A new regulatory mechanism for hCAT-1 activity.". J. Biol. Chem. 279 (52): 54185–92. doi:10.1074/jbc.M409556200. PMID 15491978.  
  • Cui Z, Tuladhar R, Hart SL, et al. (2005). "Rate of transport of l-arginine is independent of the expression of inducible nitric oxide synthase in HEK 293 cells.". Nitric Oxide 12 (1): 21–30. doi:10.1016/j.niox.2004.11.001. PMID 15631944.  
  • Yang Z, Venardos K, Jones E, et al. (2007). "Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction.". Circulation 115 (10): 1269–74. doi:10.1161/CIRCULATIONAHA.106.665836. PMID 17325243.  
  • Kaneko S, Okuda-Ashitaka E, Ando A, et al. (2007). "Polyamines upregulate the mRNA expression of cationic amino acid transporter-1 in human retinal pigment epithelial cells.". Am. J. Physiol., Cell Physiol. 293 (2): C729–37. doi:10.1152/ajpcell.00018.2007. PMID 17494634.  


Got something to say? Make a comment.
Your name
Your email address