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SLC7A11: Wikis


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Solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
Symbols SLC7A11; CCBR1; xCT
External IDs OMIM607933 MGI1347355 HomoloGene22684 GeneCards: SLC7A11 Gene
RNA expression pattern
PBB GE SLC7A11 209921 at tn.png
PBB GE SLC7A11 207528 s at tn.png
PBB GE SLC7A11 217678 at tn.png
More reference expression data
Species Human Mouse
Entrez 23657 26570
Ensembl ENSG00000151012 ENSMUSG00000027737
UniProt Q9UPY5 Q3TN05
RefSeq (mRNA) NM_014331 NM_011990
RefSeq (protein) NP_055146 NP_036120
Location (UCSC) Chr 4:
139.3 - 139.38 Mb
Chr 3:
50.46 - 50.54 Mb
PubMed search [1] [2]

Cystine/glutamate transporter is a protein that in humans is encoded by the SLC7A11 gene.[1][2][3]

SLC7A11 is a member of a heteromeric Na(+)-independent anionic amino acid transport system highly specific for cystine and glutamate. In this system, designated system Xc(-), the anionic form of cystine is transported in exchange for glutamate.[supplied by OMIM][3]

See also


  1. ^ Sato H, Tamba M, Ishii T, Bannai S (May 1999). "Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins". J Biol Chem 274 (17): 11455-8. PMID 10206947. 
  2. ^ Wang H, Tamba M, Kimata M, Sakamoto K, Bannai S, Sato H (May 2003). "Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT". Biochem Biophys Res Commun 305 (3): 611-8. PMID 12763038. 
  3. ^ a b "Entrez Gene: SLC7A11 solute carrier family 7, (cationic amino acid transporter, y+ system) member 11". 

Further reading

  • Bridges CC, Kekuda R, Wang H, et al. (2001). "Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells.". Invest. Ophthalmol. Vis. Sci. 42 (1): 47–54. PMID 11133847. 
  • Sato H, Tamba M, Kuriyama-Matsumura K, et al. (2001). "Molecular cloning and expression of human xCT, the light chain of amino acid transport system xc-.". Antioxid. Redox Signal. 2 (4): 665–71. PMID 11213471. 
  • Shih AY, Murphy TH (2001). "xCt cystine transporter expression in HEK293 cells: pharmacology and localization.". Biochem. Biophys. Res. Commun. 282 (5): 1132–7. doi:10.1006/bbrc.2001.4703. PMID 11302733. 
  • Kim JY, Kanai Y, Chairoungdua A, et al. (2001). "Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells.". Biochim. Biophys. Acta 1512 (2): 335–44. doi:10.1016/S0005-2736(01)00338-8. PMID 11406111. 
  • Bassi MT, Gasol E, Manzoni M, et al. (2001). "Identification and characterisation of human xCT that co-expresses, with 4F2 heavy chain, the amino acid transport activity system xc-.". Pflugers Arch. 442 (2): 286–96. doi:10.1007/s004240100537. PMID 11417227. 
  • Sasaki H, Sato H, Kuriyama-Matsumura K, et al. (2003). "Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression.". J. Biol. Chem. 277 (47): 44765–71. doi:10.1074/jbc.M208704200. PMID 12235164. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Jiménez-Vidal M, Gasol E, Zorzano A, et al. (2004). "Thiol modification of cysteine 327 in the eighth transmembrane domain of the light subunit xCT of the heteromeric cystine/glutamate antiporter suggests close proximity to the substrate binding site/permeation pathway.". J. Biol. Chem. 279 (12): 11214–21. doi:10.1074/jbc.M309866200. PMID 14722095. 
  • Gasol E, Jiménez-Vidal M, Chillarón J, et al. (2004). "Membrane topology of system xc- light subunit reveals a re-entrant loop with substrate-restricted accessibility.". J. Biol. Chem. 279 (30): 31228–36. doi:10.1074/jbc.M402428200. PMID 15151999. 
  • Bridges CC, Hu H, Miyauchi S, et al. (2004). "Induction of cystine-glutamate transporter xc- by human immunodeficiency virus type 1 transactivator protein tat in retinal pigment epithelium.". Invest. Ophthalmol. Vis. Sci. 45 (9): 2906–14. doi:10.1167/iovs.03-1355. PMID 15326101. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Kaleeba JA, Berger EA (2006). "Kaposi's sarcoma-associated herpesvirus fusion-entry receptor: cystine transporter xCT.". Science 311 (5769): 1921–4. doi:10.1126/science.1120878. PMID 16574866. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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