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SLC7A3: Wikis


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Solute carrier family 7 (cationic amino acid transporter, y+ system), member 3
Symbols SLC7A3; ATRC3; CAT-3; FLJ14541; MGC20687
External IDs OMIM300443 MGI1100521 HomoloGene56382 GeneCards: SLC7A3 Gene
Species Human Mouse
Entrez 84889 11989
Ensembl ENSG00000165349 ENSMUSG00000031297
UniProt Q8WY07 Q3TMH5
RefSeq (mRNA) NM_001048164 NM_007515
RefSeq (protein) NP_001041629 NP_031541
Location (UCSC) Chr X:
70.06 - 70.07 Mb
Chr X:
97.28 - 97.29 Mb
PubMed search [1] [2]

Cationic amino acid transporter 3 is a protein that in humans is encoded by the SLC7A3 gene.[1][2]

SLC7A3 is a member of the system y+ family of transporters characterized by sodium-independent transport of cationic amino acids.[supplied by OMIM][2]

See also


  1. ^ Vekony N, Wolf S, Boissel JP, Gnauert K, Closs EI (Oct 2001). "Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues". Biochemistry 40 (41): 12387-94. PMID 11591158.  
  2. ^ a b "Entrez Gene: SLC7A3 solute carrier family 7 (cationic amino acid transporter, y+ system), member 3".  

Further reading

  • Hosokawa H, Sawamura T, Kobayashi S, et al. (1997). "Cloning and characterization of a brain-specific cationic amino acid transporter.". J. Biol. Chem. 272 (13): 8717–22. doi:10.1074/jbc.272.13.8717. PMID 9079705.  
  • Ito K, Groudine M (1997). "A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain.". J. Biol. Chem. 272 (42): 26780–6. doi:10.1074/jbc.272.42.26780. PMID 9334265.  
  • Hosokawa H, Ninomiya H, Sawamura T, et al. (1999). "Neuron-specific expression of cationic amino acid transporter 3 in the adult rat brain.". Brain Res. 838 (1-2): 158–65. doi:10.1016/S0006-8993(99)01686-8. PMID 10446328.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Gilles W, Vulcu SD, Liewald JF, et al. (2005). "Monovalent cation conductance in Xenopus laevis oocytes expressing hCAT-3.". Biochim. Biophys. Acta 1668 (2): 234–9. doi:10.1016/j.bbamem.2004.12.011. PMID 15737334.  
  • Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.  
  • Rotmann A, Vékony N, Gassner D, et al. (2006). "Activation of classical protein kinase C reduces the expression of human cationic amino acid transporter 3 (hCAT-3) in the plasma membrane.". Biochem. J. 395 (1): 117–23. doi:10.1042/BJ20051558. PMID 16332251.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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