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SLC7A8: Wikis


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From Wikipedia, the free encyclopedia

Solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
Symbols SLC7A8; LAT2; LPI-PC1
External IDs OMIM604235 MGI1355323 HomoloGene8166 GeneCards: SLC7A8 Gene
RNA expression pattern
PBB GE SLC7A8 216092 s at tn.png
PBB GE SLC7A8 202752 x at tn.png
PBB GE SLC7A8 217248 s at tn.png
More reference expression data
Species Human Mouse
Entrez 23428 50934
Ensembl ENSG00000092068 ENSMUSG00000022180
UniProt Q9UHI5 Q9QXW9
RefSeq (mRNA) NM_012244 NM_016972
RefSeq (protein) NP_036376 NP_058668
Location (UCSC) Chr 14:
22.66 - 22.72 Mb
Chr 14:
53.68 - 53.74 Mb
PubMed search [1] [2]

Large neutral amino acids transporter small subunit 2 is a protein that in humans is encoded by the SLC7A8 gene.[1][2][3]

See also


  1. ^ Borsani G, Bassi MT, Sperandeo MP, De Grandi A, Buoninconti A, Riboni M, Manzoni M, Incerti B, Pepe A, Andria G, Ballabio A, Sebastio G (Mar 1999). "SLC7A7, encoding a putative permease-related protein, is mutated in patients with lysinuric protein intolerance". Nat Genet 21 (3): 297-301. doi:10.1038/6815. PMID 10080183. 
  2. ^ Pineda M, Fernandez E, Torrents D, Estevez R, Lopez C, Camps M, Lloberas J, Zorzano A, Palacin M (Aug 1999). "Identification of a membrane protein, LAT-2, that Co-expresses with 4F2 heavy chain, an L-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids". J Biol Chem 274 (28): 19738-44. PMID 10391915. 
  3. ^ "Entrez Gene: SLC7A8 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8". 

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Rossier G, Meier C, Bauch C, et al. (2000). "LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine.". J. Biol. Chem. 274 (49): 34948–54. doi:10.1074/jbc.274.49.34948. PMID 10574970. 
  • Bassi MT, Sperandeo MP, Incerti B, et al. (2000). "SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family.". Genomics 62 (2): 297–303. doi:10.1006/geno.1999.5978. PMID 10610726. 
  • Bröer A, Friedrich B, Wagner CA, et al. (2001). "Association of 4F2hc with light chains LAT1, LAT2 or y+LAT2 requires different domains.". Biochem. J. 355 (Pt 3): 725–31. PMID 11311135. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Liu X, Charrier L, Gewirtz A, et al. (2003). "CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia.". J. Biol. Chem. 278 (26): 23672–7. doi:10.1074/jbc.M302777200. PMID 12716892. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Li S, Whorton AR (2005). "Identification of stereoselective transporters for S-nitroso-L-cysteine: role of LAT1 and LAT2 in biological activity of S-nitrosothiols.". J. Biol. Chem. 280 (20): 20102–10. doi:10.1074/jbc.M413164200. PMID 15769744. 
  • Kühne A, Kaiser R, Schirmer M, et al. (2007). "Genetic polymorphisms in the amino acid transporters LAT1 and LAT2 in relation to the pharmacokinetics and side effects of melphalan.". Pharmacogenet. Genomics 17 (7): 505–17. doi:10.1097/FPC.0b013e3280ea77cd. PMID 17558306. 


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