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SLC9A2: Wikis


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Solute carrier family 9 (sodium/hydrogen exchanger), member 2
Symbols SLC9A2; NHE2
External IDs OMIM600530 MGI105075 HomoloGene20661 GeneCards: SLC9A2 Gene
Species Human Mouse
Entrez 6549 226999
Ensembl ENSG00000115616 ENSMUSG00000026062
UniProt Q9UBY0 n/a
RefSeq (mRNA) NM_003048 NM_001033289
RefSeq (protein) NP_003039 NP_001028461
Location (UCSC) Chr 2:
102.6 - 102.69 Mb
Chr 1:
40.63 - 40.71 Mb
PubMed search [1] [2]

Sodium/hydrogen exchanger 2 is a protein that in humans is encoded by the SLC9A2 gene.[1]

See also


Further reading

  • Chow CW (1999). "Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3.". Clinical and investigative medicine. Médecine clinique et experimentale 22 (5): 195–206. PMID 10579058.  
  • Kulanthaivel P, Furesz TC, Moe AJ, et al. (1992). "Human placental syncytiotrophoblast expresses two pharmacologically distinguishable types of Na(+)-H+ exchangers, NHE-1 in the maternal-facing (brush border) membrane and NHE-2 in the fetal-facing (basal) membrane.". Biochem. J. 284 ( Pt 1): 33–8. PMID 1318024.  
  • Collins JF, Honda T, Knobel S, et al. (1993). "Molecular cloning, sequencing, tissue distribution, and functional expression of a Na+/H+ exchanger (NHE-2).". Proc. Natl. Acad. Sci. U.S.A. 90 (9): 3938–42. doi:10.1073/pnas.90.9.3938. PMID 7683411.  
  • Ghishan FK, Knobel SM, Summar M (1996). "Molecular cloning, sequencing, chromosomal localization, and tissue distribution of the human Na+/H+ exchanger (SLC9A2).". Genomics 30 (1): 25–30. doi:10.1006/geno.1995.0004. PMID 8595899.  
  • Dudeja PK, Rao DD, Syed I, et al. (1996). "Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA.". Am. J. Physiol. 271 (3 Pt 1): G483–93. PMID 8843774.  
  • Lin X, Barber DL (1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange.". Proc. Natl. Acad. Sci. U.S.A. 93 (22): 12631–6. doi:10.1073/pnas.93.22.12631. PMID 8901634.  
  • "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. 1999. PMID 9847074.  
  • Chow CW, Woodside M, Demaurex N, et al. (1999). "Proline-rich motifs of the Na+/H+ exchanger 2 isoform. Binding of Src homology domain 3 and role in apical targeting in epithelia.". J. Biol. Chem. 274 (15): 10481–8. doi:10.1074/jbc.274.15.10481. PMID 10187839.  
  • Malakooti J, Dahdal RY, Schmidt L, et al. (1999). "Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2.". Am. J. Physiol. 277 (2 Pt 1): G383–90. PMID 10444453.  
  • Malakooti J, Dahdal RY, Dudeja PK, et al. (2001). "The human Na(+)/H(+) exchanger NHE2 gene: genomic organization and promoter characterization.". Am. J. Physiol. Gastrointest. Liver Physiol. 280 (4): G763–73. PMID 11254504.  
  • Pang T, Su X, Wakabayashi S, Shigekawa M (2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers.". J. Biol. Chem. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981.  
  • Repishti M, Hogan DL, Pratha V, et al. (2001). "Human duodenal mucosal brush border Na(+)/H(+) exchangers NHE2 and NHE3 alter net bicarbonate movement.". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (1): G159–63. PMID 11408268.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Lacey HA, Nolan T, Greenwood SL, et al. (2005). "Gestational profile of Na+/H+ exchanger and Cl-/HCO3- anion exchanger mRNA expression in placenta using real-time QPCR.". Placenta 26 (1): 93–8. doi:10.1016/j.placenta.2004.05.005. PMID 15664417.  
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.  
  • Pearse I, Zhu YX, Murray EJ, et al. (2007). "Sp1 and Sp3 control constitutive expression of the human NHE2 promoter by interactions with the proximal promoter and the transcription initiation site.". Biochem. J. 407 (1): 101–11. doi:10.1042/BJ20070364. PMID 17561809.  


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