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SLC9A5: Wikis


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Solute carrier family 9 (sodium/hydrogen exchanger), member 5
Symbols SLC9A5; NHE5
External IDs OMIM600477 MGI2685542 HomoloGene31247 GeneCards: SLC9A5 Gene
RNA expression pattern
PBB GE SLC9A5 220650 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6553 277973
Ensembl ENSG00000135740 ENSMUSG00000014786
UniProt Q14940 n/a
RefSeq (mRNA) NM_004594 XM_894890
RefSeq (protein) NP_004585 XP_899983
Location (UCSC) Chr 16:
65.84 - 65.86 Mb
Chr 8:
108.24 - 108.26 Mb
PubMed search [1] [2]

Sodium/hydrogen exchanger 5 is a protein that in humans is encoded by the SLC9A5 gene.[1][2][3]

See also


  1. ^ Klanke CA, Su YR, Callen DF, Wang Z, Meneton P, Baird N, Kandasamy RA, Orlowski J, Otterud BE, Leppert M, et al. (Jun 1995). "Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1". Genomics 25 (3): 615-22. PMID 7759094.  
  2. ^ Attaphitaya S, Park K, Melvin JE (Mar 1999). "Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brain". J Biol Chem 274 (7): 4383-8. PMID 9933642.  
  3. ^ "Entrez Gene: SLC9A5 solute carrier family 9 (sodium/hydrogen exchanger), member 5".  

Further reading

  • Baird NR, Orlowski J, Szabó EZ, et al. (1999). "Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain.". J. Biol. Chem. 274 (7): 4377–82. doi:10.1074/jbc.274.7.4377. PMID 9933641.  
  • Szaszi K, Paulsen A, Szabo EZ, et al. (2003). "Clathrin-mediated endocytosis and recycling of the neuron-specific Na+/H+ exchanger NHE5 isoform. Regulation by phosphatidylinositol 3'-kinase and the actin cytoskeleton.". J. Biol. Chem. 277 (45): 42623–32. doi:10.1074/jbc.M206629200. PMID 12205089.  
  • Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis.". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMID 12417987.  
  • Inoue H, Nakamura Y, Nagita M, et al. (2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium.". Biol. Pharm. Bull. 26 (2): 148–55. doi:10.1248/bpb.26.148. PMID 12576672.  
  • Lin WM, Chen XH, Xu R, et al.. "[Tissue-specific expression of Na(+)-H(+) exchanger isoforms at two developmental stages of human fetus]". Sheng li xue bao : [Acta physiologica Sinica] 55 (1): 79–82. PMID 12598940.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Szabó EZ, Numata M, Lukashova V, et al. (2005). "beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform.". Proc. Natl. Acad. Sci. U.S.A. 102 (8): 2790–5. doi:10.1073/pnas.0407444102. PMID 15699339.  
  • Onishi I, Lin PJ, Diering GH, et al. (2007). "RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity.". Cell. Signal. 19 (1): 194–203. doi:10.1016/j.cellsig.2006.06.011. PMID 16920332.  


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