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Solute carrier organic anion transporter family, member 1A2
Identifiers
Symbols SLCO1A2; OATP; OATP-A; OATP1A2; SLC21A3
External IDs OMIM602883 MGI1351896 HomoloGene56603 GeneCards: SLCO1A2 Gene
RNA expression pattern
PBB GE SLCO1A2 207308 at tn.png
PBB GE SLCO1A2 211480 s at tn.png
PBB GE SLCO1A2 211481 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 6579 28250
Ensembl ENSG00000084453 ENSMUSG00000030237
UniProt P46721 Q8C7H7
RefSeq (mRNA) NM_005075 NM_030687
RefSeq (protein) NP_005066 NP_109612
Location (UCSC) Chr 12:
21.31 - 21.44 Mb
Chr 6:
141.77 - 141.81 Mb
PubMed search [1] [2]

Solute carrier organic anion transporter family member 1A2 is a protein that in humans is encoded by the SLCO1A2 gene.[1][2]

This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternate splicing of this gene results in three transcript variants encoding two different isoforms.[2]

See also

References

  1. ^ Kullak-Ublick GA, Beuers U, Meier PJ, Domdey H, Paumgartner G (Apr 1997). "Assignment of the human organic anion transporting polypeptide (OATP) gene to chromosome 12p12 by fluorescence in situ hybridization". J Hepatol 25 (6): 985-7. PMID 9007731.  
  2. ^ a b "Entrez Gene: SLCO1A2 solute carrier organic anion transporter family, member 1A2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6579.  

Further reading

  • Meier PJ, Eckhardt U, Schroeder A, et al. (1998). "Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver.". Hepatology 26 (6): 1667–77. doi:10.1002/hep.510260641. PMID 9398014.  
  • Kullak-Ublick GA, Hagenbuch B, Stieger B, et al. (1995). "Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver.". Gastroenterology 109 (4): 1274–82. doi:10.1016/0016-5085(95)90588-X. PMID 7557095.  
  • Kullak-Ublick GA, Beuers U, Fahney C, et al. (1997). "Identification and functional characterization of the promoter region of the human organic anion transporting polypeptide gene.". Hepatology 26 (4): 991–7. doi:10.1002/hep.510260429. PMID 9328325.  
  • Kullak-Ublick GA, Fisch T, Oswald M, et al. (1998). "Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain.". FEBS Lett. 424 (3): 173–6. doi:10.1016/S0014-5793(98)00168-9. PMID 9539145.  
  • König J, Cui Y, Nies AT, Keppler D (2000). "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.". J. Biol. Chem. 275 (30): 23161–8. doi:10.1074/jbc.M001448200. PMID 10779507.  
  • Tamai I, Nezu J, Uchino H, et al. (2000). "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.". Biochem. Biophys. Res. Commun. 273 (1): 251–60. doi:10.1006/bbrc.2000.2922. PMID 10873595.  
  • Speek M (2001). "Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes.". Mol. Cell. Biol. 21 (6): 1973–85. doi:10.1128/MCB.21.6.1973-1985.2001. PMID 11238933.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Lee W, Glaeser H, Smith LH, et al. (2005). "Polymorphisms in human organic anion-transporting polypeptide 1A2 (OATP1A2): implications for altered drug disposition and central nervous system drug entry.". J. Biol. Chem. 280 (10): 9610–7. doi:10.1074/jbc.M411092200. PMID 15632119.  
  • Su Y, Zhang X, Sinko PJ (2005). "Human organic anion-transporting polypeptide OATP-A (SLC21A3) acts in concert with P-glycoprotein and multidrug resistance protein 2 in the vectorial transport of Saquinavir in Hep G2 cells.". Mol. Pharm. 1 (1): 49–56. doi:10.1021/mp0340136. PMID 15832500.  
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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