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Solute carrier organic anion transporter family, member 1B3
Identifiers
Symbols SLCO1B3; LST-3TM13; LST3; OATP1B3; OATP8; SLC21A8
External IDs OMIM605495 MGI1351899 HomoloGene75119 GeneCards: SLCO1B3 Gene
RNA expression pattern
PBB GE SLCO1B3 206354 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 28234 28253
Ensembl ENSG00000111700 ENSMUSG00000030236
UniProt Q9NPD5 Q9JJL3
RefSeq (mRNA) NM_019844 NM_020495
RefSeq (protein) NP_062818 NP_065241
Location (UCSC) Chr 12:
20.86 - 20.96 Mb
Chr 6:
141.59 - 141.65 Mb
PubMed search [1] [2]

Solute carrier organic anion transporter family member 1B3 is a protein that in humans is encoded by the SLCO1B3 gene.[1]

See also

References

Further reading

  • König J, Cui Y, Nies AT, Keppler D (2000). "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.". J. Biol. Chem. 275 (30): 23161–8. doi:10.1074/jbc.M001448200. PMID 10779507.  
  • Abe T, Unno M, Onogawa T, et al. (2001). "LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers.". Gastroenterology 120 (7): 1689–99. doi:10.1053/gast.2001.24804. PMID 11375950.  
  • Ismair MG, Stieger B, Cattori V, et al. (2001). "Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver.". Gastroenterology 121 (5): 1185–90. doi:10.1053/gast.2001.28704. PMID 11677211.  
  • Jung D, Podvinec M, Meyer UA, et al. (2002). "Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor.". Gastroenterology 122 (7): 1954–66. doi:10.1053/gast.2002.33583. PMID 12055601.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Cui Y, König J, Nies AT, et al. (2003). "Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma.". Lab. Invest. 83 (4): 527–38. PMID 12695556.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Vavricka SR, Jung D, Fried M, et al. (2004). "The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma.". J. Hepatol. 40 (2): 212–8. doi:10.1016/j.jhep.2003.10.008. PMID 14739090.  
  • Hirano M, Maeda K, Shitara Y, Sugiyama Y (2004). "Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans.". J. Pharmacol. Exp. Ther. 311 (1): 139–46. doi:10.1124/jpet.104.068056. PMID 15159445.  
  • Letschert K, Keppler D, König J (2005). "Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8).". Pharmacogenetics 14 (7): 441–52. doi:10.1097/01.fpc.0000114744.08559.92. PMID 15226676.  
  • Yamaguchi H, Okada M, Akitaya S, et al. (2006). "Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3.". J. Lipid Res. 47 (6): 1196–202. doi:10.1194/jlr.M500532-JLR200. PMID 16534140.  
  • Ohtsuka H, Abe T, Onogawa T, et al. (2006). "Farnesoid X receptor, hepatocyte nuclear factors 1alpha and 3beta are essential for transcriptional activation of the liver-specific organic anion transporter-2 gene.". J. Gastroenterol. 41 (4): 369–77. doi:10.1007/s00535-006-1784-3. PMID 16741617.  
  • Briz O, Romero MR, Martinez-Becerra P, et al. (2006). "OATP8/1B3-mediated cotransport of bile acids and glutathione: an export pathway for organic anions from hepatocytes?". J. Biol. Chem. 281 (41): 30326–35. doi:10.1074/jbc.M602048200. PMID 16877380.  
  • Mahagita C, Grassl SM, Piyachaturawat P, Ballatori N (2007). "Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport.". Am. J. Physiol. Gastrointest. Liver Physiol. 293 (1): G271–8. doi:10.1152/ajpgi.00075.2007. PMID 17412826.  
  • Treiber A, Schneiter R, Häusler S, Stieger B (2007). "Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil.". Drug Metab. Dispos. 35 (8): 1400–7. doi:10.1124/dmd.106.013615. PMID 17496208.  
  • Muto M, Onogawa T, Suzuki T, et al. (2007). "Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma.". Cancer Sci. 98 (10): 1570–6. doi:10.1111/j.1349-7006.2007.00570.x. PMID 17760952.  
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