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Staphylococcal nuclease and tudor domain containing 1

PDB rendering based on 2hqx.
Available structures
2hqx, 2o4x
Symbols SND1; p100; TDRD11
External IDs OMIM602181 MGI1929266 HomoloGene8665 GeneCards: SND1 Gene
Species Human Mouse
Entrez 27044 56463
Ensembl ENSG00000197157 ENSMUSG00000001424
UniProt Q7KZF4 Q3TJ56
RefSeq (mRNA) NM_014390 NM_019776
RefSeq (protein) NP_055205 NP_062750
Location (UCSC) Chr 7:
127.08 - 127.52 Mb
Chr 6:
28.43 - 28.84 Mb
PubMed search [1] [2]

Staphylococcal nuclease domain-containing protein 1 is an enzyme that in humans is encoded by the SND1 gene.[1][2][3][4]


SND1 has been shown to interact with PIM1,[5] STAT6,[6] RBPJ,[7][8] POLR2A[6] and MYB.[9]


  1. ^ Tong X, Drapkin R, Yalamanchili R, Mosialos G, Kieff E (Sep 1995). "The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE". Mol Cell Biol 15 (9): 4735–44. PMID 7651391.  
  2. ^ Callebaut I, Mornon JP (Feb 1997). "The human EBNA-2 coactivator p100: multidomain organization and relationship to the staphylococcal nuclease fold and to the tudor protein involved in Drosophila melanogaster development". Biochem J 321 ( Pt 1): 125–32. PMID 9003410.  
  3. ^ Paukku K, Yang J, Silvennoinen O (Aug 2003). "Tudor and nuclease-like domains containing protein p100 function as coactivators for signal transducer and activator of transcription 5". Mol Endocrinol 17 (9): 1805–14. doi:10.1210/me.2002-0256. PMID 12819296.  
  4. ^ "Entrez Gene: SND1 staphylococcal nuclease and tudor domain containing 1".  
  5. ^ Leverson, J D; Koskinen P J, Orrico F C, Rainio E M, Jalkanen K J, Dash A B, Eisenman R N, Ness S A (Oct. 1998). "Pim-1 kinase and p100 cooperate to enhance c-Myb activity". Mol. Cell (UNITED STATES) 2 (4): 417–25. ISSN 1097-2765. PMID 9809063.  
  6. ^ a b Yang, Jie; Aittomäki Saara, Pesu Marko, Carter Kara, Saarinen Jussi, Kalkkinen Nisse, Kieff Elliott, Silvennoinen Olli (Sep. 2002). "Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II". EMBO J. (England) 21 (18): 4950–8. ISSN 0261-4189. PMID 12234934.  
  7. ^ Zhou, S; Fujimuro M, Hsieh J J, Chen L, Hayward S D (Feb. 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". J. Virol. (UNITED STATES) 74 (4): 1939–47. ISSN 0022-538X. PMID 10644367.  
  8. ^ Hsieh, J J; Zhou S, Chen L, Young D B, Hayward S D (Jan. 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (1): 23–8. ISSN 0027-8424. PMID 9874765.  
  9. ^ Dash, A B; Orrico F C, Ness S A (Aug. 1996). "The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb". Genes Dev. (UNITED STATES) 10 (15): 1858–69. ISSN 0890-9369. PMID 8756344.  

Further reading

  • Dash AB, Orrico FC, Ness SA (1996). "The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb.". Genes Dev. 10 (15): 1858–69. doi:10.1101/gad.10.15.1858. PMID 8756344.  
  • Leverson JD, Koskinen PJ, Orrico FC, et al. (1998). "Pim-1 kinase and p100 cooperate to enhance c-Myb activity.". Mol. Cell 2 (4): 417–25. doi:10.1016/S1097-2765(00)80141-0. PMID 9809063.  
  • Liénard P, Rivière M, Van Vooren P, et al. (2001). "Assignment of SND1, the gene encoding coactivator p100, to human chromosome 7q31.3 and rat chromosome 4q23 by in situ hybridization.". Cytogenet. Cell Genet. 90 (3-4): 253–4. doi:10.1159/000056783. PMID 11124528.  
  • Rushton JJ, Ness SA (2001). "The conserved DNA binding domain mediates similar regulatory interactions for A-Myb, B-Myb, and c-Myb transcription factors.". Blood Cells Mol. Dis. 27 (2): 459–63. doi:10.1006/bcmd.2001.0405. PMID 11259168.  
  • Broadhurst MK, Wheeler TT (2001). "The p100 coactivator is present in the nuclei of mammary epithelial cells and its abundance is increased in response to prolactin in culture and in mammary tissue during lactation.". J. Endocrinol. 171 (2): 329–37. doi:10.1677/joe.0.1710329. PMID 11691653.  
  • Yang J, Aittomäki S, Pesu M, et al. (2002). "Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II.". Embo J. 21 (18): 4950–8. doi:10.1093/emboj/cdf463. PMID 12234934.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Tijms MA, Snijder EJ (2003). "Equine arteritis virus non-structural protein 1, an essential factor for viral subgenomic mRNA synthesis, interacts with the cellular transcription co-factor p100.". J. Gen. Virol. 84 (Pt 9): 2317–22. doi:10.1099/vir.0.19297-0. PMID 12917451.  
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.  
  • Broadhurst MK, Lee RS, Hawkins S, Wheeler TT (2005). "The p100 EBNA-2 coactivator: a highly conserved protein found in a range of exocrine and endocrine cells and tissues in cattle.". Biochim. Biophys. Acta 1681 (2-3): 126–33. doi:10.1016/j.bbaexp.2004.10.009. PMID 15627504.  
  • Välineva T, Yang J, Palovuori R, Silvennoinen O (2005). "The transcriptional co-activator protein p100 recruits histone acetyltransferase activity to STAT6 and mediates interaction between the CREB-binding protein and STAT6.". J. Biol. Chem. 280 (15): 14989–96. doi:10.1074/jbc.M410465200. PMID 15695802.  
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  
  • Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.  
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.  
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.  


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