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SNRPB2: Wikis


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From Wikipedia, the free encyclopedia

Small nuclear ribonucleoprotein polypeptide B

PDB rendering based on 1a9n.
Available structures
Symbols SNRPB2; MGC24807; MGC45309
External IDs OMIM603520 MGI104805 HomoloGene37728 GeneCards: SNRPB2 Gene
RNA expression pattern
PBB GE SNRPB2 202505 at tn.png
More reference expression data
Species Human Mouse
Entrez 6629 20639
Ensembl ENSG00000125870 ENSMUSG00000008333
UniProt P08579 Q62378
RefSeq (mRNA) NM_003092 NM_021335
RefSeq (protein) NP_003083 NP_067310
Location (UCSC) Chr 20:
16.66 - 16.67 Mb
Chr 2:
142.75 - 142.76 Mb
PubMed search [1] [2]

U2 small nuclear ribonucleoprotein B is a protein that in humans is encoded by the SNRPB2 gene.[1][2]

The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene.[2]


Further reading

  • Feeney RJ, Zieve GW (1990). "Nuclear exchange of the U1 and U2 snRNP-specific proteins.". J. Cell Biol. 110 (4): 871–81. doi:10.1083/jcb.110.4.871. PMID 2139037.  
  • Laitinen J, Saris P, Hölttä E, Pettersson I (1995). "U2-snRNP B" protein gene is an early growth-inducible gene.". J. Cell. Biochem. 58 (4): 490–8. doi:10.1002/jcb.240580412. PMID 7593271.  
  • Hong W, Bennett M, Xiao Y, et al. (1997). "Association of U2 snRNP with the spliceosomal complex E.". Nucleic Acids Res. 25 (2): 354–61. doi:10.1093/nar/25.2.354. PMID 9016565.  
  • Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins.". Cell 90 (6): 1013–21. doi:10.1016/S0092-8674(00)80367-0. PMID 9323129.  
  • Moraitou M, Patrinou-Georgoula M, Guialis A (1998). "Structural/functional properties of a mammalian multi-component structure containing all major spliceosomal small nuclear ribonucleoprotein particles.". Biochem. J. 332 ( Pt 1): 135–44. PMID 9576861.  
  • Price SR, Evans PR, Nagai K (1998). "Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA.". Nature 394 (6694): 645–50. doi:10.1038/29234. PMID 9716128.  
  • Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex.". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.  
  • Bühler D, Raker V, Lührmann R, Fischer U (2000). "Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy.". Hum. Mol. Genet. 8 (13): 2351–7. doi:10.1093/hmg/8.13.2351. PMID 10556282.  
  • Pellizzoni L, Charroux B, Rappsilber J, et al. (2001). "A functional interaction between the survival motor neuron complex and RNA polymerase II.". J. Cell Biol. 152 (1): 75–85. doi:10.1083/jcb.152.1.75. PMID 11149922.  
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.  
  • Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation.". Nature 414 (6866): 929–33. doi:10.1038/414929a. PMID 11780068.  
  • Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.". RNA 8 (4): 426–39. doi:10.1017/S1355838202021088. PMID 11991638.  
  • Chung S, Zhou Z, Huddleston KA, et al. (2002). "Crooked neck is a component of the human spliceosome and implicated in the splicing process.". Biochim. Biophys. Acta 1576 (3): 287–97. PMID 12084575.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.  
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.  


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