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Suppressor of cytokine signaling 1
Identifiers
Symbols SOCS1; CIS1; CISH1; JAB; SOCS-1; SSI-1; SSI1; TIP3
External IDs OMIM603597 MGI1354910 HomoloGene2776 GeneCards: SOCS1 Gene
RNA expression pattern
PBB GE SOCS1 210001 s at tn.png
PBB GE SOCS1 209999 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8651 12703
Ensembl ENSG00000185338 ENSMUSG00000038037
UniProt O15524 O35716
RefSeq (mRNA) NM_003745 NM_009896
RefSeq (protein) NP_003736 NP_034026
Location (UCSC) Chr 16:
11.26 - 11.26 Mb
Chr 16:
10.7 - 10.7 Mb
PubMed search [1] [2]

Suppressor of cytokine signaling 1 is a protein that in humans is encoded by the SOCS1 gene.[1][2]

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.[3]

Contents

See also

Interactions

Suppressor of cytokine signaling 1 has been shown to interact with Janus kinase 2,[4][5][6][7][8][9] Growth hormone receptor,[10] CD117,[11] IRS2,[12] Colony stimulating factor 1 receptor[13] and TEC.[14]

References

  1. ^ Yoshimura A, Ohkubo T, Kiguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Hara T, Miyajima A (Aug 1995). "A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors". EMBO J 14 (12): 2816–26. PMID 7796808.  
  2. ^ Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, Matsumoto T, Saito H, Hosoe S, Kishimoto T (Sep 1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3". Biochem Biophys Res Commun 237 (1): 79–83. doi:10.1006/bbrc.1997.7080. PMID 9266833.  
  3. ^ "Entrez Gene: SOCS1 suppressor of cytokine signaling 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8651.  
  4. ^ Yasukawa, H; Misawa H, Sakamoto H, Masuhara M, Sasaki A, Wakioka T, Ohtsuka S, Imaizumi T, Matsuda T, Ihle J N, Yoshimura A (Mar. 1999). "The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop". EMBO J. (ENGLAND) 18 (5): 1309–20. doi:10.1093/emboj/18.5.1309. ISSN 0261-4189. PMID 10064597.  
  5. ^ Dif, F; Saunier E, Demeneix B, Kelly P A, Edery M (Dec. 2001). "Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor". Endocrinology (United States) 142 (12): 5286–93. ISSN 0013-7227. PMID 11713228.  
  6. ^ Endo, T A; Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Matsumoto A, Tanimura S, Ohtsubo M, Misawa H, Miyazaki T, Leonor N, Taniguchi T, Fujita T, Kanakura Y, Komiya S, Yoshimura A (Jun. 1997). "A new protein containing an SH2 domain that inhibits JAK kinases". Nature (ENGLAND) 387 (6636): 921–4. doi:10.1038/43213. ISSN 0028-0836. PMID 9202126.  
  7. ^ Pezet, A; Favre H, Kelly P A, Edery M (Aug. 1999). "Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling". J. Biol. Chem. (UNITED STATES) 274 (35): 24497–502. ISSN 0021-9258. PMID 10455112.  
  8. ^ Ungureanu, Daniela; Saharinen Pipsa, Junttila Ilkka, Hilton Douglas J, Silvennoinen Olli (May. 2002). "Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1". Mol. Cell. Biol. (United States) 22 (10): 3316–26. ISSN 0270-7306. PMID 11971965.  
  9. ^ Masuhara, M; Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (Oct. 1997). "Cloning and characterization of novel CIS family genes". Biochem. Biophys. Res. Commun. (UNITED STATES) 239 (2): 439–46. doi:10.1006/bbrc.1997.7484. ISSN 0006-291X. PMID 9344848.  
  10. ^ Ram, P A; Waxman D J (Dec. 1999). "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms". J. Biol. Chem. (UNITED STATES) 274 (50): 35553–61. ISSN 0021-9258. PMID 10585430.  
  11. ^ De Sepulveda, P; Okkenhaug K, Rose J L, Hawley R G, Dubreuil P, Rottapel R (Feb. 1999). "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation". EMBO J. (ENGLAND) 18 (4): 904–15. doi:10.1093/emboj/18.4.904. ISSN 0261-4189. PMID 10022833.  
  12. ^ Rui, Liangyou; Yuan Minsheng, Frantz Daniel, Shoelson Steven, White Morris F (Nov. 2002). "SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2". J. Biol. Chem. (United States) 277 (44): 42394–8. doi:10.1074/jbc.C200444200. ISSN 0021-9258. PMID 12228220.  
  13. ^ Bourette, R P; De Sepulveda P, Arnaud S, Dubreuil P, Rottapel R, Mouchiroud G (Jun. 2001). "Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal". J. Biol. Chem. (United States) 276 (25): 22133–9. doi:10.1074/jbc.M101878200. ISSN 0021-9258. PMID 11297560.  
  14. ^ Ohya, K i; Kajigaya S, Yamashita Y, Miyazato A, Hatake K, Miura Y, Ikeda U, Shimada K, Ozawa K, Mano H (Oct. 1997). "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase". J. Biol. Chem. (UNITED STATES) 272 (43): 27178–82. ISSN 0021-9258. PMID 9341160.  

Further reading

  • Krebs DL, Hilton DJ (2001). "SOCS proteins: negative regulators of cytokine signaling.". Stem Cells 19 (5): 378–87. doi:10.1634/stemcells.19-5-378. PMID 11553846.  
  • Wang J, Campbell IL (2002). "Cytokine signaling in the brain: putting a SOCS in it?". J. Neurosci. Res. 67 (4): 423–7. doi:10.1002/jnr.10145. PMID 11835308.  
  • Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation.". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.  
  • Starr R, Willson TA, Viney EM, et al. (1997). "A family of cytokine-inducible inhibitors of signalling.". Nature 387 (6636): 917–21. doi:10.1038/43206. PMID 9202125.  
  • Endo TA, Masuhara M, Yokouchi M, et al. (1997). "A new protein containing an SH2 domain that inhibits JAK kinases.". Nature 387 (6636): 921–4. doi:10.1038/43213. PMID 9202126.  
  • Ohya K, Kajigaya S, Yamashita Y, et al. (1997). "SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase.". J. Biol. Chem. 272 (43): 27178–82. doi:10.1074/jbc.272.43.27178. PMID 9341160.  
  • Dey BR, Spence SL, Nissley P, Furlanetto RW (1998). "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor.". J. Biol. Chem. 273 (37): 24095–101. doi:10.1074/jbc.273.37.24095. PMID 9727029.  
  • De Sepulveda P, Okkenhaug K, Rose JL, et al. (1999). "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.". EMBO J. 18 (4): 904–15. doi:10.1093/emboj/18.4.904. PMID 10022833.  
  • Zhang JG, Farley A, Nicholson SE, et al. (1999). "The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 2071–6. doi:10.1073/pnas.96.5.2071. PMID 10051596.  
  • Yasukawa H, Misawa H, Sakamoto H, et al. (1999). "The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop.". EMBO J. 18 (5): 1309–20. doi:10.1093/emboj/18.5.1309. PMID 10064597.  
  • Marine JC, Topham DJ, McKay C, et al. (1999). "SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality.". Cell 98 (5): 609–16. doi:10.1016/S0092-8674(00)80048-3. PMID 10490100.  
  • Yandava CN, Pillari A, Drazen JM (1999). "Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively.". Genomics 61 (1): 108–11. doi:10.1006/geno.1999.5937. PMID 10512686.  
  • Okabe S, Tauchi T, Morita H, et al. (1999). "Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway.". Exp. Hematol. 27 (10): 1542–7. doi:10.1016/S0301-472X(99)00094-6. PMID 10517496.  
  • Ram PA, Waxman DJ (2000). "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms.". J. Biol. Chem. 274 (50): 35553–61. doi:10.1074/jbc.274.50.35553. PMID 10585430.  
  • Sporri B, Kovanen PE, Sasaki A, et al. (2001). "JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling.". Blood 97 (1): 221–6. doi:10.1182/blood.V97.1.221. PMID 11133764.  
  • Kawazoe Y, Naka T, Fujimoto M, et al. (2001). "Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation.". J. Exp. Med. 193 (2): 263–9. doi:10.1084/jem.193.2.263. PMID 11208867.  
  • Bourette RP, De Sepulveda P, Arnaud S, et al. (2001). "Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal.". J. Biol. Chem. 276 (25): 22133–9. doi:10.1074/jbc.M101878200. PMID 11297560.  
  • Mooney RA, Senn J, Cameron S, et al. (2001). "Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance.". J. Biol. Chem. 276 (28): 25889–93. doi:10.1074/jbc.M010579200. PMID 11342531.  
  • Bellezza I, Neuwirt H, et al. (2006). "Suppressor of Cytokine Signaling-3 Antagonizes cAMP Effects on Proliferation and Apoptosis and Is Expressed in Human Prostate Cancer.". American Journal of Pathology 169: 2199–2208. doi:10.2353/ajpath.2006.060171. PMID 17148681.  
  • Neuwirt H, Puhr M, et al. (2009). "Suppressor of Cytokine Signaling (SOCS)-1 Is Expressed in Human Prostate Cancer and Exerts Growth-Inhibitory Function through Down-Regulation of Cyclins and Cyclin-Dependent Kinases.". American Journal of Pathology 174: 921–1930. doi:10.2353/ajpath.2009.080751. PMID 19342366.  

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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