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Suppressor of cytokine signaling 5
Symbols SOCS5; CIS6; CISH6; Cish5; KIAA0671; SOCS-5
External IDs OMIM607094 MGI2385459 HomoloGene10495 GeneCards: SOCS5 Gene
Species Human Mouse
Entrez 9655 56468
Ensembl n/a ENSMUSG00000037104
UniProt n/a Q3UXZ1
RefSeq (mRNA) NM_014011 NM_019654
RefSeq (protein) NP_054730 NP_062628
Location (UCSC) n/a Chr 17:
87.02 - 87.05 Mb
PubMed search [1] [2]

Suppressor of cytokine signaling 5 is a protein that in humans is encoded by the SOCS5 gene.[1][2][3]

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.[3]


  1. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res 5 (3): 169-76. PMID 9734811.  
  2. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.  
  3. ^ a b "Entrez Gene: SOCS5 suppressor of cytokine signaling 5".  

Further reading

  • Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation.". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.  
  • Wang J, Campbell IL (2002). "Cytokine signaling in the brain: putting a SOCS in it?". J. Neurosci. Res. 67 (4): 423–7. doi:10.1002/jnr.10145. PMID 11835308.  
  • Krebs DL, Hilton DJ (2001). "SOCS proteins: negative regulators of cytokine signaling.". Stem Cells 19 (5): 378–87. doi:10.1634/stemcells.19-5-378. PMID 11553846.  
  • Ozaki A, Seki Y, Fukushima A, Kubo M (2005). "The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine model.". J. Immunol. 175 (8): 5489–97. PMID 16210657.  
  • Kario E, Marmor MD, Adamsky K, et al. (2005). "Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling.". J. Biol. Chem. 280 (8): 7038–48. doi:10.1074/jbc.M408575200. PMID 15590694.  
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  
  • Bayle J, Letard S, Frank R, et al. (2004). "Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling.". J. Biol. Chem. 279 (13): 12249–59. doi:10.1074/jbc.M313381200. PMID 14707129.  
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  
  • Seki Y, Hayashi K, Matsumoto A, et al. (2002). "Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation.". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 13003–8. doi:10.1073/pnas.202477099. PMID 12242343.  
  • Magrangeas F, Apiou F, Denis S, et al. (2000). "Cloning and expression of CIS6, chromosome assignment to 3p22 and 2p21 by in situ hybridization.". Cytogenet. Cell Genet. 88 (1-2): 78–81. doi:10.1159/000015490. PMID 10773671.  
  • Hilton DJ, Richardson RT, Alexander WS, et al. (1998). "Twenty proteins containing a C-terminal SOCS box form five structural classes.". Proc. Natl. Acad. Sci. U.S.A. 95 (1): 114–9. doi:10.1073/pnas.95.1.114. PMID 9419338.  


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